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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>People with a 16p11.2 duplication have an extra copy of a segment of genetic material on the short (p) arm of chromosome 16 at a position known as p11.2. This duplication affects one of the two copies of chromosome 16 in each cell. The length of the duplicated segment is most often about 600,000 DNA building blocks (base pairs), also written as 600 kilobases (kb). The 600 kb region contains more than 25 genes, and little is known about the function of most of these genes. Researchers are working to determine how the extra genetic material contributes to the features of 16p11.2 duplication.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/16p112-duplication/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes 16p11.2 duplication?"},{"bodyHtml":"<p>Developmental delay and intellectual disability can occur in people with a 16p11.2 duplication. Approximately one-third of children with this condition have delays in developing physical skills such as sitting, crawling, or walking. The average IQ of affected individuals is about 26 points lower than that of their parents without the duplication. About 80 percent of people with a 16p11.2 duplication have problems related to speech or language. Both expressive language skills (vocabulary and the production of speech) and receptive language skills (the ability to understand speech) can be affected.</p><p>One of the most common behavioral problems associated with this chromosomal change is attention-deficit/hyperactivity disorder (ADHD). Autism spectrum disorder, which affects communication and social skills, is diagnosed in about one in five people with a 16p11.2 duplication. Affected individuals also have an increased risk of mental health problems, including schizophrenia, anxiety, and depression. Recurrent seizures are possible in this condition, although they do not occur in most affected individuals.</p><p>Other abnormalities that can occur with a 16p11.2 duplication include malformations of the kidneys and urinary tract. However, there is no particular pattern of physical abnormalities that characterizes 16p11.2 duplications; signs and symptoms related to the chromosomal change vary even among affected members of the same family.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/16p112-duplication\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"16p112-duplication","sourceDocuments":[{"name":"16p11.2 duplication","reviewed":"2014-10","sections":{"causes":{"fetchedAt":"2026-10-20T20:18:48.509252+00:00","label":"Causes","pageSha256":"db468119731215076b27f94dccbc483ca88f4496f3c4a3ab1be72fab37f04d9e","sourceUrl":"https://medlineplus.gov/genetics/condition/16p112-duplication/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/16p112-duplication"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"16p11.2 duplication"},"schemaVersion":1}