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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Most people with 3q29 microduplication syndrome have an extra copy of about 1.6 million DNA building blocks (base pairs), also written as 1.6 megabases (Mb), at position q29 on chromosome 3. However, the duplication can vary in size. It affects one of the two copies of chromosome 3 in each cell.</p><p>The segment that gets duplicated is surrounded by short, repeated sequences of DNA that make it prone to rearrangement during cell division. The rearrangement can lead to missing or extra copies of DNA at 3q29. (A missing copy of this segment causes another condition called 3q29 microdeletion syndrome.)</p><p>The chromosome segment most commonly duplicated in people with 3q29 microduplication syndrome contains about 20 genes. Some of these genes are thought to be involved in brain and eye development. However, it is unknown which specific genes, when abnormally copied, are related to the varied signs and symptoms of 3q29 microduplication syndrome. It is also unclear why some people with a duplication at 3q29 have no associated health problems. It is possible that genetic changes outside the 3q29 region can influence the features of this condition.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/3q29-microduplication-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes 3q29 microduplication syndrome?"},{"bodyHtml":"<p>The features associated with 3q29 microduplication syndrome vary widely. Some individuals with this chromosomal change have very mild or no related signs and symptoms, and the duplication is discovered because they undergo genetic testing only after a family member is diagnosed. Other people with a 3q29 microduplication have delayed development (particularly speech delay) and intellectual disability or learning difficulties. Although most affected individuals have no major birth defects, eye abnormalities, heart defects, and an unusually small head (microcephaly) can occur. 3q29 microduplication syndrome may increase the likelihood of being overweight or having obesity, although it is hard to determine whether these weight issues are caused by the duplication.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/3q29-microduplication-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"3q29-microduplication-syndrome","sourceDocuments":[{"name":"3q29 microduplication syndrome","reviewed":"2017-08","sections":{"causes":{"fetchedAt":"2026-10-20T20:18:56.888728+00:00","label":"Causes","pageSha256":"8a8fadd06862e9f0d2b0d7018c768cec7e154414a0f0374b443854c98e1d690a","sourceUrl":"https://medlineplus.gov/genetics/condition/3q29-microduplication-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/3q29-microduplication-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"3q29 microduplication syndrome"},"schemaVersion":1}