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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>5q- syndrome is caused by deletion of a region of DNA from the long (q) arm of chromosome 5. Most people with 5q- syndrome are missing a sequence of about 1.5 million DNA building blocks (base pairs), also written as 1.5 megabases (Mb). However, the size of the deleted region varies. This deletion occurs in immature blood cells during a person&#x27;s lifetime and affects one of the two copies of chromosome 5 in each cell.</p><p>The commonly deleted region of DNA contains 40 genes, many of which play a critical role in normal blood cell development. Research suggests that loss of multiple genes in this region contributes to the features of 5q- syndrome. Loss of the RPS14 gene leads to the problems with red blood cell development characteristic of 5q- syndrome, and loss of MIR145 or MIR146A contributes to the megakaryocyte and platelet abnormalities and may promote the overgrowth of immature cells. Scientists are still determining how the loss of other genes in the deleted region might be involved in the features of 5q- syndrome.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/5q-minus-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes 5q minus syndrome?"},{"bodyHtml":"<p>MDS is considered a slow-growing (chronic) blood cancer. It can progress to a fast-growing blood cancer called acute myeloid leukemia (AML). Progression to AML occurs less commonly in people with 5q- syndrome than in those with other forms of MDS.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/5q-minus-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"5q-minus-syndrome","sourceDocuments":[{"name":"5q minus syndrome","reviewed":"2015-11","sections":{"causes":{"fetchedAt":"2026-10-20T20:18:59.226702+00:00","label":"Causes","pageSha256":"5e7c0c17d330a1792bd0e39faa7127e04d8b67bc3fd97d0f5bfe606c419a91f8","sourceUrl":"https://medlineplus.gov/genetics/condition/5q-minus-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/5q-minus-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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