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href=\"https://medlineplus.gov/genetics/condition/adiposis-dolorosa\">Adiposis dolorosa</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>The cause of adiposis dolorosa is unknown. Although a few families with multiple affected family members have been reported, no genetic cause has been identified.</p><p>Several possible causes of adiposis dolorosa have been suggested, but none have been confirmed. These include infections, swelling (inflammation), traumatic events, or changes in the deposition and breakdown of fat (adipose tissue metabolism). Changes or abnormalities in the nervous system, immune system, or the hormone-producing endocrine system have also been proposed as possible causes of adiposis dolorosa.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/adiposis-dolorosa/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Adiposis dolorosa?"},{"bodyHtml":"<p>Adiposis dolorosa affects the adipose tissue. Adipose tissue is found in many parts of the body. It stores fat for energy and provides support for the body’s structures. In some individuals, lipomas develop within the adipose tissue. These lipomas can occur anywhere on the body, but they are most often found on the torso, buttocks, or the upper arms and legs. The lipomas in people with adiposis dolorosa usually feel like firm bumps (nodules) underneath the skin and tend to be painful. The pain can be severe, particularly if the lipomas are pressing on a nearby nerve. In some people, the pain is disabling.</p><p>People with adiposis dolorosa may experience additional signs and symptoms. However, these features do not occur in all people with adiposis dolorosa, and it is unclear whether they are directly related to the condition. Researchers are working to learn more about the signs and symptoms of this condition.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/adiposis-dolorosa\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"adiposis-dolorosa","sourceDocuments":[{"name":"Adiposis dolorosa","reviewed":"2026-02","sections":{"causes":{"fetchedAt":"2026-10-20T20:19:09.266451+00:00","label":"Causes","pageSha256":"85778f482a5b02f30391bafecdae1dbafbdb40c70497932ec4d23c6237f703fe","sourceUrl":"https://medlineplus.gov/genetics/condition/adiposis-dolorosa/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/adiposis-dolorosa"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Adiposis dolorosa"},"schemaVersion":1}