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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in the ALMS1 gene cause Alström syndrome. The ALMS1 gene provides instructions for making a protein whose function is unknown. Mutations in this gene probably lead to the production of an abnormally short, nonfunctional version of the ALMS1 protein. This protein is normally present at low levels in most tissues, so a loss of the protein&#x27;s normal function may help explain why the signs and symptoms of Alström syndrome affect many parts of the body.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/alstrom-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Alström syndrome?"},{"bodyHtml":"<p>Alström syndrome is characterized by a progressive loss of vision and hearing, a form of heart disease that enlarges and weakens the heart muscle (dilated cardiomyopathy), obesity, type 2 diabetes (the most common form of diabetes), and short stature. This disorder can also cause serious or life-threatening medical problems involving the liver, kidneys, bladder, and lungs. Some individuals with Alström syndrome have a skin condition called acanthosis nigricans, which causes the skin in body folds and creases to become thick, dark, and velvety. The signs and symptoms of Alström syndrome vary in severity, and not all affected individuals have all of the characteristic features of the disorder.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/alstrom-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"alstrom-syndrome","sourceDocuments":[{"name":"Alström syndrome","reviewed":"2008-08","sections":{"causes":{"fetchedAt":"2026-10-20T20:19:18.990889+00:00","label":"Causes","pageSha256":"f00ee98ada4d9e8d093ae2286e885dc6b86e951b0708ccb9c74729595d25af06","sourceUrl":"https://medlineplus.gov/genetics/condition/alstrom-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/alstrom-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Alström syndrome"},"schemaVersion":1}