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Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.</p>"},"coverage":{"countRecords":9,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":11,"sourceGroups":{"omim":0,"orphanet":2,"published":9}},"features":[{"hpoId":"HP:0030511","label":"Bradyopsia","primary":false},{"hpoId":"HP:0030512","label":"Difficulty adjusting to changes in luminance","primary":false},{"hpoId":"HP:0000639","label":"Nystagmus","primary":false},{"hpoId":"HP:0000613","label":"Photophobia","primary":false},{"hpoId":"HP:0007663","label":"Reduced visual acuity","primary":false},{"hpoId":"HP:0000505","label":"Visual impairment","primary":false}],"ledeHtml":"Bradyopsia is a rare condition that affects vision. The term &quot;bradyopsia&quot; is from the Greek words for slow vision. In affected individuals, the eyes adapt more slowly than usual to changing light conditions. 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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Bradyopsia can be caused by mutations in the RGS9 gene or in the RGS9BP gene (which is also known as R9AP). These genes provide instructions for making proteins that are necessary for normal vision. The proteins are found in light-detecting cells in the eye called photoreceptors. When light enters the eye, it stimulates specialized pigments in these cells. This stimulation triggers a series of chemical reactions that produce an electrical signal, which is interpreted by the brain as vision. Once photoreceptors have been stimulated by light, they must return to their resting state before they can be stimulated again. The RGS9 and RGS9BP proteins play an essential role in returning photoreceptors to their resting state quickly after light exposure.</p><p>Mutations in either the RGS9 or RGS9BP gene prevent photoreceptors from recovering quickly after responding to light. Normally they return to their resting state in a fraction of a second, but in people with mutations in one of these genes, it can take ten seconds or longer. During that time, the photoreceptors cannot respond to light. This delay causes temporary blindness in response to changing light conditions and interferes with seeing small objects when they are in motion.</p><p>In some people with bradyopsia, no mutations in the RGS9 or RGS9BP gene have been found. The cause of the condition in these individuals is unknown.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/bradyopsia/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Bradyopsia?"},{"bodyHtml":"<p>Some people with bradyopsia also have difficulty seeing some moving objects, particularly small objects moving against a bright background. As a result, they often have trouble watching or participating in sports with a ball, such as soccer or tennis. People with bradyopsia can have reduced sharpness (acuity) of vision, although acuity may depend on the conditions under which vision is tested. Visual acuity may appear to be severely affected if it is tested under bright lights, but it can be near normal if tested in a dim environment. The ability to see colors and distinguish between them is normal.</p><p>The vision problems associated with bradyopsia become apparent in early childhood. They are usually stable, which means they do not worsen over time.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/bradyopsia\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"bradyopsia","sourceDocuments":[{"name":"Bradyopsia","reviewed":"2014-11","sections":{"causes":{"fetchedAt":"2026-10-20T20:19:56.517997+00:00","label":"Causes","pageSha256":"9bf3d026263fe498b3de19b81a20fc7fcfcd1d69853a85344a80dc4a3397d192","sourceUrl":"https://medlineplus.gov/genetics/condition/bradyopsia/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/bradyopsia"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Bradyopsia"},"schemaVersion":1}