{"frequencyBands":{"HP:0040280":[100,100],"HP:0040281":[80,99],"HP:0040282":[30,79],"HP:0040283":[5,29],"HP:0040284":[1,4],"HP:0040285":[0,0]},"page":{"columns":[{"gene":"","key":"MONDO:0011001/OMIM:601144","label":"Brugada syndrome 1","mondoId":"MONDO:0011001","onsetQualifier":null,"recordKeys":["0ef8874f9f2f7360d9b3fc7002a66aac698d4b1d83cfb6ba51fd3afab676b570","49559e0102df0a32234576af447c46eaa1ab66348ad5e40b65df2a7095e82549","709253859dd0e7e9a7f1cc70ad060b502108e17cc8508b4698eba280a549b407","7327b4f4b2231a8e5cf307d72a234198c09b8c71f6f1b6460a1458ae8ef14ba5","75108a9c9ad532f2784ec8f7b5a89c045b7ec62fa083cef150d0d2bf2f7af150","861844fec6a9e87be351add7c72aeeb603d6aee7c34f00d3bf71779178ab2cea","dc71f7e6e46c5cf8e76eaa63bc79569c9c42cf192d914e6b1d2d4b998013d59f","e7bddca57d1bbf23a3e2556fcb26c70445f47623c5641f9a843572e06243c743"],"recordQualifiers":{},"scopeLabel":"OMIM:601144","sourceIds":["OMIM:601144"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0012728/OMIM:611777","label":"Brugada syndrome 2","mondoId":"MONDO:0012728","onsetQualifier":null,"recordKeys":["0525301bcfd995c156bb25dcd4cf3aafe02b47b4d04285bacdc43b0a7db049e6","205f25bdc30dc0bf848142beb803379b6ada31abf07f84f92537e3215774c4f2","88969d6ce30becc29a3d4c95e55518f2d7f0542646bf26fa5893b460b95ed2a7","e9610c3e6fcbaf39bf69b73e140a64a2feca8cc524eb6567fa4468476bd0cf35","ea44e5e152984309e52fd8fd7dafd8d84dafab1137a85e92e638d29afe66f9d4","fca124774be6753139de838615a4415081d8b9d9d7c181a29b8a5ee3e8d56014"],"recordQualifiers":{},"scopeLabel":"OMIM:611777","sourceIds":["OMIM:611777"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0012742/OMIM:611875","label":"Brugada syndrome 3","mondoId":"MONDO:0012742","onsetQualifier":null,"recordKeys":["4e6d17b6cb8daf2890015393d9ab5694fbec9978f4a0d9c9e944acfbf075a8bf","872dc4b3309f848363f474864ef7f16bacf7304a9937943d6f1c97dbd8a82ed7","a3f7f96ec6e066c858b407941d0c3271bb731e46f815ce3715655494f9832c96","c9d83e10ff6c59a5204d7fcd1765b496ea2f0c322e10cbd513bed37d4820c8bc","cdc9a7db59d85f5c06b90595b5082a6771bac7fedbd9334637410b8f15d55c4b","d4503c39ea2951f7cf1ffa65ccc1c5779e78bc0cf980b2ac8ab0adfed8b0d2ce"],"recordQualifiers":{},"scopeLabel":"OMIM:611875","sourceIds":["OMIM:611875"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0012743/OMIM:611876","label":"Brugada syndrome 4","mondoId":"MONDO:0012743","onsetQualifier":null,"recordKeys":["0588b321421834020261bcfc3796a859eadbf5d1558fde96b4270f8e551778c3","39941db4d58aafd3b47fdbb31bb70e56db46dd168e6114e8594d70be60f003e9","e1a7c4d08724a6706227b8b67257310bb1cc503a3688fedebc1c6927baf6ba0c"],"recordQualifiers":{},"scopeLabel":"OMIM:611876","sourceIds":["OMIM:611876"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0013015/OMIM:612838","label":"Brugada syndrome 5","mondoId":"MONDO:0013015","onsetQualifier":null,"recordKeys":["744df950ed588640ee7f5275a624e49a85ea102c502727cc18e38b56f41371f6","e95329cd8cb4cb27e6122679a2a54e207e92c541e742f93aba00ff3c723d83ff","f6e2f6c045f09e46aa1caba3b43b5ca9cd3c6b9136abf48164731ea42fd808f5"],"recordQualifiers":{},"scopeLabel":"OMIM:612838","sourceIds":["OMIM:612838"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0013145/OMIM:613119","label":"Brugada syndrome 6","mondoId":"MONDO:0013145","onsetQualifier":null,"recordKeys":["60074a6180cbe9becb304d48ed28d76ac7944ae6c557ca5f5541db82e099be3d","9abdebf0486c34dba9ed7bf271a31d65c0c610f738f17c3c17a58d5fd66b5561","f5db8ce17c0a8c5390a4918598822d4d357c2ed05605bb96c5a2a05361376f72"],"recordQualifiers":{},"scopeLabel":"OMIM:613119","sourceIds":["OMIM:613119"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0013148/OMIM:613123","label":"Brugada syndrome 8","mondoId":"MONDO:0013148","onsetQualifier":null,"recordKeys":["7fd3432d0556427142f3c73d140f0fd8ca341ec923f43dfb6692b7841e80f38b","a8f3baa34b4abaf6b2ca7aa5e3a15b2e5b1c2b357e7402b98205abcad7016444","e195903d5c8294b0149c82bc1ec6cd0f70b1e33e759140d4f52343bbb30e4636"],"recordQualifiers":{},"scopeLabel":"OMIM:613123","sourceIds":["OMIM:613123"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0014621/OMIM:616399","label":"Brugada syndrome 9","mondoId":"MONDO:0014621","onsetQualifier":null,"recordKeys":["0282ba9f1d8ae1c873699f02a01d466fc350016558772b6830880dc3f871f458","69d169e8e9c09eaa23845e1a0eef88adf74b611fd3af6ea56255586213111a1e","79403cdebf6ce10f3dc513fa251c6fb4a67277ffe93e00f810507a3c7c197046","e8afc3da9de76ffb2642def0be9c516724b211f85b1d7f8cc52ce482613b9861"],"recordQualifiers":{},"scopeLabel":"OMIM:616399","sourceIds":["OMIM:616399"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0015263/ORPHA:130","label":"Brugada syndrome","mondoId":"MONDO:0015263","onsetQualifier":null,"recordKeys":["230a202550c0dd894706529cde44f171adac167f9a12af5e2f7a5e3d4c0b33d3","3294c9272183808400e73a5d79ee002e87cf04a88f8d7da0d36d93f93ecc6920","3f4702ae347375b9bd1c030f5d663b2760a2e88395474416d3786a21ff1baf54","4f9b467267f23a10bc67249e99dc354781237a63a10748e16f56c745e89d7123","5f72eabceb0db23471a107e578dc2fdc892692f4bf794ebf5e95e1bb82178a6f","6e833803dd2249e009e3e819a1e9c9b9dac69831d7bf4be137c92f35af7b38ce","9febf818a0701e5b0b2db469307308eeab08a715fcb76c51550d6c5c38edc70a","a80fdf6d24025edcb287f80d7e599f3e8407edb4b026d72fbcc38dbea7eabe76","bf207a24023705c72368947dccf5473f68efad0e74a805d8deccdb8c1f424d42","cec20df722950f66b404d1b93fdea92e8bf4a6a295ef76a2124db306fac850c4","ef4f3dcb4c1abbba5e18a2eecb7c6f9a9d60877d84631f797bf88aed0566b581","f0d89fa8c7f419e51472b082cecbc08b16007c8b666995cf9b463fda029d48d2"],"recordQualifiers":{},"scopeLabel":"ORPHA:130","sourceIds":["ORPHA:130"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."}],"comparison":{"collapseColumnsLabel":"Show initial comparisons","defaultColumnKeys":["MONDO:0011001/OMIM:601144","MONDO:0012728/OMIM:611777","MONDO:0012742/OMIM:611875","MONDO:0012743/OMIM:611876"],"expandColumnsLabel":"Compare all source entries","intro":"Compare the original source entries. Different entries may describe different patient groups.","primaryFeatureIds":[],"scopeNoteHtml":"<p>Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.</p>"},"coverage":{"countRecords":15,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":48,"sourceGroups":{"omim":0,"orphanet":12,"published":36}},"features":[{"hpoId":"HP:0005110","label":"Atrial fibrillation","primary":false},{"hpoId":"HP:0004749","label":"Atrial flutter","primary":false},{"hpoId":"HP:0011710","label":"Bundle branch block","primary":false},{"hpoId":"HP:0001695","label":"Cardiac arrest","primary":false},{"hpoId":"HP:0011712","label":"Complete right bundle branch block","primary":false},{"hpoId":"HP:0011705","label":"First degree atrioventricular block","primary":false},{"hpoId":"HP:0012272","label":"J wave","primary":false},{"hpoId":"HP:0001962","label":"Palpitations","primary":false},{"hpoId":"HP:0004751","label":"Paroxysmal ventricular tachycardia","primary":false},{"hpoId":"HP:0031972","label":"Presyncope","primary":false},{"hpoId":"HP:0012248","label":"Prolonged PR interval","primary":false},{"hpoId":"HP:0001657","label":"Prolonged QT interval","primary":false},{"hpoId":"HP:0012232","label":"Shortened QT interval","primary":false},{"hpoId":"HP:0011704","label":"Sick sinus syndrome","primary":false},{"hpoId":"HP:0012251","label":"ST segment elevation","primary":false},{"hpoId":"HP:0001645","label":"Sudden cardiac death","primary":false},{"hpoId":"HP:0004755","label":"Supraventricular tachycardia","primary":false},{"hpoId":"HP:0011688","label":"Supraventricular tachycardia with an accessory connection mediated pathway","primary":false},{"hpoId":"HP:0001279","label":"Syncope","primary":false},{"hpoId":"HP:0001649","label":"Tachycardia","primary":false},{"hpoId":"HP:0011715","label":"Trifascicular block","primary":false},{"hpoId":"HP:0004308","label":"Ventricular arrhythmia","primary":false},{"hpoId":"HP:0001663","label":"Ventricular fibrillation","primary":false},{"hpoId":"HP:0004756","label":"Ventricular tachycardia","primary":false}],"ledeHtml":"Brugada syndrome is a condition that causes a disruption of the heart&#x27;s normal rhythm. Specifically, this disorder can lead to irregular heartbeats in the heart&#x27;s lower chambers (ventricles), which is an abnormality called ventricular arrhythmia. If untreated, the irregular heartbeats can cause fainting (syncope), seizures, difficulty breathing, or sudden death. These complications typically occur when an affected person is resting or asleep.","mondoId":"MONDO:0015263","records":[{"frequencyKind":"count","key":"0282ba9f1d8ae1c873699f02a01d466fc350016558772b6830880dc3f871f458","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:616399","disease_name":"Brugada syndrome 9","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0031972","is_excluded":false,"label":"Presyncope","onset_id":null,"reference":"PMID:21349352","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"0525301bcfd995c156bb25dcd4cf3aafe02b47b4d04285bacdc43b0a7db049e6","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611777","disease_name":"Brugada syndrome 2","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0011705","is_excluded":false,"label":"First degree atrioventricular block","onset_id":null,"reference":"PMID:17967977","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"0588b321421834020261bcfc3796a859eadbf5d1558fde96b4270f8e551778c3","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611876","disease_name":"Brugada syndrome 4","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0012232","is_excluded":false,"label":"Shortened QT interval","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"0ef8874f9f2f7360d9b3fc7002a66aac698d4b1d83cfb6ba51fd3afab676b570","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0011712","is_excluded":false,"label":"Complete right bundle branch block","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"205f25bdc30dc0bf848142beb803379b6ada31abf07f84f92537e3215774c4f2","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611777","disease_name":"Brugada syndrome 2","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001279","is_excluded":false,"label":"Syncope","onset_id":null,"reference":"PMID:17967977","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"230a202550c0dd894706529cde44f171adac167f9a12af5e2f7a5e3d4c0b33d3","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040284","hpo_id":"HP:0004308","is_excluded":false,"label":"Ventricular arrhythmia","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"3294c9272183808400e73a5d79ee002e87cf04a88f8d7da0d36d93f93ecc6920","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001695","is_excluded":false,"label":"Cardiac arrest","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"39941db4d58aafd3b47fdbb31bb70e56db46dd168e6114e8594d70be60f003e9","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611876","disease_name":"Brugada syndrome 4","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0005110","is_excluded":false,"label":"Atrial fibrillation","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"3f4702ae347375b9bd1c030f5d663b2760a2e88395474416d3786a21ff1baf54","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0012251","is_excluded":false,"label":"ST segment elevation","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"49559e0102df0a32234576af447c46eaa1ab66348ad5e40b65df2a7095e82549","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":"27/49","hpo_id":"HP:0001279","is_excluded":false,"label":"Syncope","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"4e6d17b6cb8daf2890015393d9ab5694fbec9978f4a0d9c9e944acfbf075a8bf","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611875","disease_name":"Brugada syndrome 3","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0012232","is_excluded":false,"label":"Shortened QT interval","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"4f9b467267f23a10bc67249e99dc354781237a63a10748e16f56c745e89d7123","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0011712","is_excluded":false,"label":"Complete right bundle branch block","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5f72eabceb0db23471a107e578dc2fdc892692f4bf794ebf5e95e1bb82178a6f","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040284","hpo_id":"HP:0011715","is_excluded":false,"label":"Trifascicular block","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"60074a6180cbe9becb304d48ed28d76ac7944ae6c557ca5f5541db82e099be3d","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:613119","disease_name":"Brugada syndrome 6","evidence":"PCS","frequency_raw":"4/4","hpo_id":"HP:0012251","is_excluded":false,"label":"ST segment elevation","onset_id":null,"reference":"PMID:19122847","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"69d169e8e9c09eaa23845e1a0eef88adf74b611fd3af6ea56255586213111a1e","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:616399","disease_name":"Brugada syndrome 9","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0001657","is_excluded":false,"label":"Prolonged QT interval","onset_id":null,"reference":"PMID:21349352","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"6e833803dd2249e009e3e819a1e9c9b9dac69831d7bf4be137c92f35af7b38ce","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0001663","is_excluded":false,"label":"Ventricular fibrillation","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"709253859dd0e7e9a7f1cc70ad060b502108e17cc8508b4698eba280a549b407","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":"11/49","hpo_id":"HP:0001695","is_excluded":false,"label":"Cardiac arrest","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"7327b4f4b2231a8e5cf307d72a234198c09b8c71f6f1b6460a1458ae8ef14ba5","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":"21/49","hpo_id":"HP:0005110","is_excluded":false,"label":"Atrial fibrillation","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"744df950ed588640ee7f5275a624e49a85ea102c502727cc18e38b56f41371f6","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:612838","disease_name":"Brugada syndrome 5","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0012251","is_excluded":false,"label":"ST segment elevation","onset_id":null,"reference":"PMID:18464934","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"75108a9c9ad532f2784ec8f7b5a89c045b7ec62fa083cef150d0d2bf2f7af150","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":"26/49","hpo_id":"HP:0001663","is_excluded":false,"label":"Ventricular fibrillation","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"79403cdebf6ce10f3dc513fa251c6fb4a67277ffe93e00f810507a3c7c197046","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:616399","disease_name":"Brugada syndrome 9","evidence":"PCS","frequency_raw":"2/2","hpo_id":"HP:0012251","is_excluded":false,"label":"ST segment elevation","onset_id":null,"reference":"PMID:21349352","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"7fd3432d0556427142f3c73d140f0fd8ca341ec923f43dfb6692b7841e80f38b","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:613123","disease_name":"Brugada syndrome 8","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0011712","is_excluded":false,"label":"Complete right bundle branch block","onset_id":null,"reference":"PMID:19165230","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"861844fec6a9e87be351add7c72aeeb603d6aee7c34f00d3bf71779178ab2cea","raw":{"aspect":"P","body_system":"other","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001645","is_excluded":false,"label":"Sudden cardiac death","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"872dc4b3309f848363f474864ef7f16bacf7304a9937943d6f1c97dbd8a82ed7","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611875","disease_name":"Brugada syndrome 3","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001279","is_excluded":false,"label":"Syncope","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"88969d6ce30becc29a3d4c95e55518f2d7f0542646bf26fa5893b460b95ed2a7","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611777","disease_name":"Brugada syndrome 2","evidence":"PCS","frequency_raw":"7/12","hpo_id":"HP:0012248","is_excluded":false,"label":"Prolonged PR interval","onset_id":null,"reference":"PMID:11839626","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"9abdebf0486c34dba9ed7bf271a31d65c0c610f738f17c3c17a58d5fd66b5561","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:613119","disease_name":"Brugada syndrome 6","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001695","is_excluded":false,"label":"Cardiac arrest","onset_id":null,"reference":"PMID:19122847","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"9febf818a0701e5b0b2db469307308eeab08a715fcb76c51550d6c5c38edc70a","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0004755","is_excluded":false,"label":"Supraventricular tachycardia","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"a3f7f96ec6e066c858b407941d0c3271bb731e46f815ce3715655494f9832c96","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611875","disease_name":"Brugada syndrome 3","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0005110","is_excluded":false,"label":"Atrial fibrillation","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"a80fdf6d24025edcb287f80d7e599f3e8407edb4b026d72fbcc38dbea7eabe76","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0011705","is_excluded":false,"label":"First degree atrioventricular block","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"a8f3baa34b4abaf6b2ca7aa5e3a15b2e5b1c2b357e7402b98205abcad7016444","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:613123","disease_name":"Brugada syndrome 8","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0012251","is_excluded":false,"label":"ST segment elevation","onset_id":null,"reference":"PMID:19165230","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"bf207a24023705c72368947dccf5473f68efad0e74a805d8deccdb8c1f424d42","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0004751","is_excluded":false,"label":"Paroxysmal ventricular tachycardia","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"c9d83e10ff6c59a5204d7fcd1765b496ea2f0c322e10cbd513bed37d4820c8bc","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611875","disease_name":"Brugada syndrome 3","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0004308","is_excluded":false,"label":"Ventricular arrhythmia","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"cdc9a7db59d85f5c06b90595b5082a6771bac7fedbd9334637410b8f15d55c4b","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611875","disease_name":"Brugada syndrome 3","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0012272","is_excluded":false,"label":"J wave","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"cec20df722950f66b404d1b93fdea92e8bf4a6a295ef76a2124db306fac850c4","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001279","is_excluded":false,"label":"Syncope","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"d4503c39ea2951f7cf1ffa65ccc1c5779e78bc0cf980b2ac8ab0adfed8b0d2ce","raw":{"aspect":"P","body_system":"other","disease_id":"OMIM:611875","disease_name":"Brugada syndrome 3","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001645","is_excluded":false,"label":"Sudden cardiac death","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"dc71f7e6e46c5cf8e76eaa63bc79569c9c42cf192d914e6b1d2d4b998013d59f","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":"5/49","hpo_id":"HP:0011688","is_excluded":false,"label":"Supraventricular tachycardia with an accessory connection mediated pathway","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"e195903d5c8294b0149c82bc1ec6cd0f70b1e33e759140d4f52343bbb30e4636","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:613123","disease_name":"Brugada syndrome 8","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0004756","is_excluded":false,"label":"Ventricular tachycardia","onset_id":null,"reference":"PMID:19165230","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"e1a7c4d08724a6706227b8b67257310bb1cc503a3688fedebc1c6927baf6ba0c","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611876","disease_name":"Brugada syndrome 4","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001279","is_excluded":false,"label":"Syncope","onset_id":null,"reference":"PMID:17224476","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"e7bddca57d1bbf23a3e2556fcb26c70445f47623c5641f9a843572e06243c743","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:601144","disease_name":"Brugada syndrome 1","evidence":"PCS","frequency_raw":"3/49","hpo_id":"HP:0004749","is_excluded":false,"label":"Atrial flutter","onset_id":null,"reference":"PMID:33221895","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"e8afc3da9de76ffb2642def0be9c516724b211f85b1d7f8cc52ce482613b9861","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:616399","disease_name":"Brugada syndrome 9","evidence":"PCS","frequency_raw":"2/2","hpo_id":"HP:0001962","is_excluded":false,"label":"Palpitations","onset_id":null,"reference":"PMID:21349352","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"e95329cd8cb4cb27e6122679a2a54e207e92c541e742f93aba00ff3c723d83ff","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:612838","disease_name":"Brugada syndrome 5","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0011710","is_excluded":false,"label":"Bundle branch block","onset_id":null,"reference":"PMID:18464934","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"e9610c3e6fcbaf39bf69b73e140a64a2feca8cc524eb6567fa4468476bd0cf35","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611777","disease_name":"Brugada syndrome 2","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001663","is_excluded":false,"label":"Ventricular fibrillation","onset_id":null,"reference":"PMID:17967977","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"ea44e5e152984309e52fd8fd7dafd8d84dafab1137a85e92e638d29afe66f9d4","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:611777","disease_name":"Brugada syndrome 2","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0011712","is_excluded":false,"label":"Complete right bundle branch block","onset_id":null,"reference":"PMID:17967977","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"ef4f3dcb4c1abbba5e18a2eecb7c6f9a9d60877d84631f797bf88aed0566b581","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0001649","is_excluded":false,"label":"Tachycardia","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"f0d89fa8c7f419e51472b082cecbc08b16007c8b666995cf9b463fda029d48d2","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:130","disease_name":"Brugada syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0011704","is_excluded":false,"label":"Sick sinus syndrome","onset_id":null,"reference":"ORPHA:130","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"f5db8ce17c0a8c5390a4918598822d4d357c2ed05605bb96c5a2a05361376f72","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:613119","disease_name":"Brugada syndrome 6","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001663","is_excluded":false,"label":"Ventricular fibrillation","onset_id":null,"reference":"PMID:19122847","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"f6e2f6c045f09e46aa1caba3b43b5ca9cd3c6b9136abf48164731ea42fd808f5","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:612838","disease_name":"Brugada syndrome 5","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0001663","is_excluded":false,"label":"Ventricular fibrillation","onset_id":null,"reference":"PMID:18464934","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"fca124774be6753139de838615a4415081d8b9d9d7c181a29b8a5ee3e8d56014","raw":{"aspect":"P","body_system":"other","disease_id":"OMIM:611777","disease_name":"Brugada syndrome 2","evidence":"PCS","frequency_raw":"HP:0040283","hpo_id":"HP:0001645","is_excluded":false,"label":"Sudden cardiac death","onset_id":null,"reference":"PMID:17967977","source_release":"2026-06-23"},"sourceGroups":["published"]}],"referenceLabels":{},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/brugada-syndrome\">Brugada syndrome</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Brugada syndrome can be caused by mutations in one of several genes. The most commonly mutated gene in this condition is SCN5A, which is altered in approximately 30 percent of affected individuals. This gene provides instructions for making a sodium channel, which normally transports positively charged sodium atoms (ions) into heart muscle cells. This type of ion channel plays a critical role in maintaining the heart&#x27;s normal rhythm. Mutations in the SCN5A gene alter the structure or function of the channel, which reduces the flow of sodium ions into cells. A disruption in ion transport alters the way the heart beats, leading to the abnormal heart rhythm characteristic of Brugada syndrome.</p><p>Mutations in other genes can also cause Brugada syndrome. Together, these other genetic changes account for less than two percent of cases of the condition. Some of the additional genes involved in Brugada syndrome provide instructions for making proteins that ensure the correct location or function of sodium channels in heart muscle cells. Proteins produced by other genes involved in the condition form or help regulate ion channels that transport calcium or potassium into or out of heart muscle cells. As with sodium channels, proper flow of ions through calcium and potassium channels in the heart muscle helps maintain a regular heartbeat. Mutations in these genes disrupt the flow of ions, impairing the heart&#x27;s normal rhythm.</p><p>In affected people without an identified gene mutation, the cause of Brugada syndrome is often unknown. In some cases, certain drugs may cause a nongenetic (acquired) form of the disorder. Drugs that can induce an altered heart rhythm include medications used to treat some forms of arrhythmia, a condition called angina (which causes chest pain), high blood pressure, depression, and other mental illnesses. Abnormally high blood levels of calcium (hypercalcemia) or potassium (hyperkalemia), as well as unusually low potassium levels (hypokalemia), also have been associated with acquired Brugada syndrome. In addition to causing a nongenetic form of this disorder, these factors may trigger symptoms in people with an underlying mutation in SCN5A or another gene.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/brugada-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Brugada syndrome?"},{"bodyHtml":"<p>Brugada syndrome usually becomes apparent in adulthood, although it can develop any time throughout life. Signs and symptoms related to arrhythmias, including sudden death, can occur from early infancy to late adulthood. Sudden death typically occurs around age 40. This condition may explain some cases of sudden infant death syndrome (SIDS), which is a major cause of death in babies younger than 1 year. SIDS is characterized by sudden and unexplained death, usually during sleep.</p><p>Sudden unexplained nocturnal death syndrome (SUNDS) is a condition characterized by unexpected cardiac arrest in young adults, usually at night during sleep. This condition was originally described in Southeast Asian populations, where it is a major cause of death. Researchers have determined that SUNDS and Brugada syndrome are the same disorder.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/brugada-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"brugada-syndrome","sourceDocuments":[{"name":"Brugada syndrome","reviewed":"2015-03","sections":{"causes":{"fetchedAt":"2026-10-20T20:19:58.520252+00:00","label":"Causes","pageSha256":"4e1397a177f451d2d238e5ecd9801d7502cc593ac85a26c16b1367adc15fae02","sourceUrl":"https://medlineplus.gov/genetics/condition/brugada-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/brugada-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Brugada syndrome"},"schemaVersion":1}