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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Congenital afibrinogenemia results from mutations in one of three genes, FGA, FGB, or FGG. Each of these genes provides instructions for making one part (subunit) of a protein called fibrinogen. This protein is important for blood clot formation (coagulation), which is needed to stop excessive bleeding after injury. In response to injury, fibrinogen is converted to fibrin, the main protein in blood clots. Fibrin proteins attach to each other, forming a stable network that makes up the blood clot.</p><p>Congenital afibrinogenemia is caused by a complete absence of fibrinogen protein. Most FGA, FGB, and FGG gene mutations that cause this condition result in a premature stop signal in the instructions for making the respective protein. If any protein is made, it is nonfunctional. When any one subunit is missing, the fibrinogen protein is not assembled, which results in the absence of fibrin. Consequently, blood clots do not form in response to injury, leading to the excessive bleeding seen in people with congenital afibrinogenemia.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/congenital-afibrinogenemia/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Congenital afibrinogenemia?"},{"bodyHtml":"<p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/congenital-afibrinogenemia\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"congenital-afibrinogenemia","sourceDocuments":[{"name":"Congenital afibrinogenemia","reviewed":"2012-02","sections":{"causes":{"fetchedAt":"2026-10-20T20:20:32.018363+00:00","label":"Causes","pageSha256":"39cbc69225aa81d214d6321809db1bd499837e6bf1887f1d596966e246ae97bb","sourceUrl":"https://medlineplus.gov/genetics/condition/congenital-afibrinogenemia/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/congenital-afibrinogenemia"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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