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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in the FGFR2 gene cause Crouzon syndrome. This gene provides instructions for making a protein called fibroblast growth factor receptor 2. Among its multiple functions, this protein signals immature cells to become bone cells during embryonic development. Mutations in the FGFR2 gene are thought to result in production of an FGFR2 protein with overactive signaling, which causes the bones of the skull to fuse prematurely.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/crouzon-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Crouzon syndrome?"},{"bodyHtml":"<p>Many features of Crouzon syndrome result from the premature fusion of the skull bones. Abnormal growth of these bones leads to wide-set, bulging eyes and vision problems caused by shallow eye sockets; eyes that do not point in the same direction (strabismus); a beaked nose; and an underdeveloped upper jaw. In addition, people with Crouzon syndrome may have dental problems and hearing loss, which is sometimes accompanied by narrow ear canals. A few individuals with Crouzon syndrome have an opening in the lip and the roof of the mouth (cleft lip and palate). The severity of these signs and symptoms varies among affected people. Individuals with Crouzon syndrome usually have normal intelligence.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/crouzon-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"crouzon-syndrome","sourceDocuments":[{"name":"Crouzon syndrome","reviewed":"2008-02","sections":{"causes":{"fetchedAt":"2026-10-20T20:20:46.059111+00:00","label":"Causes","pageSha256":"27f3f73e47351c6b652e42bbf4a485d4a8e436673febb2e46c69c15c195808bb","sourceUrl":"https://medlineplus.gov/genetics/condition/crouzon-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/crouzon-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Crouzon syndrome"},"schemaVersion":1}