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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Distal arthrogryposis type 1 can be caused by mutations in at least two genes: TPM2 and MYBPC1. These genes are active (expressed) in muscle cells, where they interact with other muscle proteins to help regulate the tensing of muscle fibers (muscle contraction). It is unclear how mutations in the TPM2 and MYBPC1 genes lead to the joint abnormalities characteristic of distal arthrogryposis type 1. However, researchers speculate that contractures may be related to problems with muscle contraction that limit the movement of joints before birth.</p><p>In some cases, the genetic cause of distal arthrogryposis type 1 is unknown. Researchers are looking for additional genetic changes that may be responsible for this condition.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/distal-arthrogryposis-type-1/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Distal arthrogryposis type 1?"},{"bodyHtml":"<p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/distal-arthrogryposis-type-1\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"distal-arthrogryposis-type-1","sourceDocuments":[{"name":"Distal arthrogryposis type 1","reviewed":"2011-01","sections":{"causes":{"fetchedAt":"2026-10-20T20:20:59.522297+00:00","label":"Causes","pageSha256":"09d8146a96dd7175681636d7cc63042949713dfd12432c68541f1a75978e5975","sourceUrl":"https://medlineplus.gov/genetics/condition/distal-arthrogryposis-type-1/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/distal-arthrogryposis-type-1"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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