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hyperbilirubinemia","onset_id":null,"reference":"OMIM:237500","source_release":"2026-06-23"},"sourceGroups":["omim"]}],"referenceLabels":{},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/dubin-johnson-syndrome\">Dubin-Johnson syndrome</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Dubin-Johnson syndrome is caused by changes in a gene known as ABCC2. The ABCC2 gene provides instructions for making a protein that transports certain substances out of cells so they can be released (excreted) from the body. For example, this protein transports a substance called bilirubin out of liver cells and into bile (a digestive fluid produced by the liver). Bilirubin is produced during the breakdown of old red blood cells and has an orange-yellow tint.</p><p>ABCC2 gene mutations result in the production of a protein with reduced or absent activity that cannot effectively transport substances out of cells. These mutations particularly affect moving bilirubin into bile. As a result, bilirubin accumulates in the body, causing a condition called hyperbilirubinemia. The buildup of bilirubin in the body causes the yellowing of the skin and whites of the eyes in people with Dubin-Johnson syndrome. The black liver in affected individuals is due to a buildup of different substance normally transported out of the liver by the protein produced from the ABCC2 gene.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/dubin-johnson-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Dubin-Johnson syndrome?"},{"bodyHtml":"<p>Rarely, jaundice develops soon after birth in individuals with Dubin-Johnson syndrome. Affected infants typically also have enlarged livers (hepatomegaly) and a severely reduced ability to produce and release a digestive fluid called bile (cholestasis). As these children get older, their liver problems go away and they usually do not have any related health problems later in life.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/dubin-johnson-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"dubin-johnson-syndrome","sourceDocuments":[{"name":"Dubin-Johnson syndrome","reviewed":"2009-03","sections":{"causes":{"fetchedAt":"2026-10-20T20:21:05.178556+00:00","label":"Causes","pageSha256":"8c6be620a6dc2ef5d5441850e313f0aec48d80553c92813f0cdce28506084929","sourceUrl":"https://medlineplus.gov/genetics/condition/dubin-johnson-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/dubin-johnson-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Dubin-Johnson syndrome"},"schemaVersion":1}