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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>The inherited form of factor VII deficiency, known as congenital factor VII deficiency, is caused by mutations in the F7 gene, which provides instructions for making a protein called coagulation factor VII. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury. These mutations reduce the amount of coagulation factor VII in the bloodstream. Such a reduction prevents blood from clotting normally, causing episodes of excessive bleeding. It is not known why some people with this condition have problems with thrombosis. Researchers are also do not know what determines the severity of the condition; it does not appear to be related to the amount of coagulation factor VII in the bloodstream.</p><p>The noninherited form of the disorder, called acquired factor VII deficiency, is less common than the congenital form. It can be caused by liver disease or by blood cell disorders such as myeloma or aplastic anemia. Acquired factor VII deficiency can also be caused by certain drugs such as medicines that prevent clotting, or by a deficiency of vitamin K.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/factor-vii-deficiency/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Factor VII deficiency?"},{"bodyHtml":"<p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/factor-vii-deficiency\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"factor-vii-deficiency","sourceDocuments":[{"name":"Factor VII deficiency","reviewed":"2016-10","sections":{"causes":{"fetchedAt":"2026-10-20T20:21:18.211129+00:00","label":"Causes","pageSha256":"b793bf61dd20063ca7a4d899be5c678473f009e300ed2dc23790790ac8ccccdb","sourceUrl":"https://medlineplus.gov/genetics/condition/factor-vii-deficiency/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/factor-vii-deficiency"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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