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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Variants (also called mutations) in the HOXA13 gene cause hand-foot-genital syndrome. The HOXA13 gene provides instructions for producing a protein that plays an important role in development before birth. Specifically, this protein appears to be critical for the formation and development of the limbs (particularly the hands and feet), urinary tract, and reproductive system.</p><p>Variants in the HOXA13 gene cause the characteristic features of hand-foot-genital syndrome by disrupting the early development of these structures. Some variants in the HOXA13 gene cause nonfunctional versions of the HOXA13 protein to be produced. Other variants alter the protein&#x27;s structure and interfere with its normal function within cells. Variants that result in an altered but functional HOXA13 protein may cause more severe signs and symptoms of hand-foot-genital syndrome than variants that lead to a nonfunctional version of this protein.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/hand-foot-genital-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Hand-foot-genital syndrome?"},{"bodyHtml":"<p>Abnormalities of the genitals and urinary tract can vary among affected individuals. Many people with hand-foot-genital syndrome have defects in the ureters, which are tubes that carry urine from each kidney to the bladder, or in the urethra, which carries urine from the bladder to the outside of the body. Recurrent urinary tract infections and an inability to control the flow of urine (urinary incontinence) have been reported. About half of males with this disorder have the urethra opening on the underside of the penis (hypospadias).</p><p>People with hand-foot-genital syndrome are usually able to have children (fertile). In some affected females, problems in the early development of the uterus can later increase the risk of pregnancy loss, premature labor, and stillbirth.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/hand-foot-genital-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"hand-foot-genital-syndrome","sourceDocuments":[{"name":"Hand-foot-genital syndrome","reviewed":"2023-10","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:01.141040+00:00","label":"Causes","pageSha256":"436894b33e211dd3660e49d0ecce6a0fccd3c851f375392a2d0ba0faff384699","sourceUrl":"https://medlineplus.gov/genetics/condition/hand-foot-genital-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/hand-foot-genital-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Hand-foot-genital syndrome"},"schemaVersion":1}