Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.
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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"Genetic changes that cause disease are called pathogenic variants. Pathogenic variants in the CCBE1, ADAMTS3, or FAT4 gene cause Hennekam syndrome.
The CCBE1 and ADAMTS3 genes provide instructions for making proteins that are found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. The CCBE1 and ADAMTS3 proteins work together to help regulate the activity of another protein called vascular endothelial growth factor receptor 3 (VEGFR3). This protein plays an important role in the development and maintenance of the lymphatic system.
The CCBE1 and ADAMTS3 gene variants that cause Hennekam syndrome reduce the amount of functional protein that is available to help regulate the activity of VEGFR3. A disruption in VEGFR3 activity impairs the development of the lymphatic system and contributes to the lymphangiectasia and lymphedema seen in people with Hennekam syndrome. Since the lymphatic system extends throughout the body, a disruption in its early development may change the balance of fluids and impair the normal development of other structures.
Research suggests that the protein produced from the FAT4 gene is involved in determining the position of cells and their components within various tissues. Proper cell positioning within a tissue allows cells to coordinate their activity and plays an important role in tissue structure and function. The FAT4 gene variants that cause Hennekam syndrome interfere with the proper positioning of cells within the developing lymphatic vessels, which contributes to the lymphangiectasia and lymphedema seen in affected individuals.
","key":"forms","title":"What causes Hennekam syndrome?"},{"bodyHtml":"The lymphedema in people with Hennekam syndrome is typically present at birth and often affects the legs and genitalia. Severely affected infants may have extensive swelling caused by fluid buildup before birth (hydrops fetalis).
People with Hennekam syndrome may have lymphangiectasia in the kidneys, lungs, and the membrane covering the heart (pericardium). Many affected infants have intestinal lymphangiectasia, which affects the vessels that transport lymph to and from the intestines. This can cause lymph to leak into the intestines, which can interfere with the absorption of proteins and other nutrients. Affected individuals may also have a buildup of lymph in the abdomen, which can cause swelling (chylous ascites). The lymphedema that is seen in individuals with Hennekam syndrome may affect one side of the body more severely than the other.
Distinctive facial features are common among people with Hennekam syndrome. Affected individuals often have a flattened appearance to the middle of the face and the bridge of the nose, puffy eyelids, widely spaced eyes (hypertelorism), low-set ears, and a small mouth with overgrowth of the gums (gingival hypertrophy). Some individuals with Hennekam syndrome have intellectual disabilities, and these can range from mild to severe. Seizures and growth delays may also occur.
The skeletal abnormalities that can be seen in people with Hennekam syndrome include a premature fusion of the skull bones (craniosynostosis), permanently bent fingers and toes (camptodactyly), and a fusion of the skin between the fingers and toes (cutaneous syndactyly). Affected individuals may also have inward- and upward-turning feet (clubfeet), a narrow upper chest that may have a sunken appearance (pectus excavatum), and an abnormal side-to-side curvature of the spine (scoliosis).
Additional features can include structural abnormalities of the heart, kidneys, or genitals; a soft out-pouching around the belly-button (umbilical hernia); hearing loss; and excessive body hair (hirsutism).
The signs and symptoms of Hennekam syndrome vary widely, even among members of the same family. Because of the potentially serious complications, the life expectancy of individuals with Hennekam syndrome also varies.
Source: MedlinePlus Genetics
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