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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Hepatic lipase deficiency is caused by mutations in the LIPC gene. This gene provides instructions for making an enzyme called hepatic lipase. This enzyme is produced by liver cells and released into the bloodstream where it helps convert very low-density lipoproteins (VLDLs) and intermediate-density lipoproteins (IDLs) to LDLs. The enzyme also assists in transporting HDLs that carry cholesterol and triglycerides from the blood to the liver, where the HDLs deposit these fats so they can be redistributed to other tissues or removed from the body.</p><p>LIPC gene mutations prevent the release of hepatic lipase from the liver or decrease the enzyme&#x27;s activity in the bloodstream. As a result, VLDLs and IDLs are not efficiently converted into LDLs, and HDLs carrying cholesterol and triglycerides remain in the bloodstream. It is unclear what effect this change in lipid levels has on people with hepatic lipase deficiency.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/hepatic-lipase-deficiency/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Hepatic lipase deficiency?"},{"bodyHtml":"<p>Normally, high levels of HDL (known as &quot;good cholesterol&quot;) and low levels of LDL (known as &quot;bad cholesterol&quot;) are protective against an accumulation of fatty deposits on the artery walls (atherosclerosis) and heart disease. However, some individuals with hepatic lipase deficiency, who have this imbalance of HDL and LDL, develop atherosclerosis and heart disease in mid-adulthood, while others do not. It is unknown whether people with hepatic lipase deficiency have a greater risk of developing atherosclerosis or heart disease than individuals in the general population. Similarly, it is unclear how increased blood triglycerides and cholesterol levels affect the risk of atherosclerosis and heart disease in people with hepatic lipase deficiency.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/hepatic-lipase-deficiency\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"hepatic-lipase-deficiency","sourceDocuments":[{"name":"Hepatic lipase deficiency","reviewed":"2015-11","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:03.775908+00:00","label":"Causes","pageSha256":"7b7ec0f732463fd8fcfa832b5d3631a27857ee6ba27a7d22c6825b1d7fb1354e","sourceUrl":"https://medlineplus.gov/genetics/condition/hepatic-lipase-deficiency/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/hepatic-lipase-deficiency"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Hepatic lipase deficiency"},"schemaVersion":1}