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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in the SCN4A gene can cause hyperkalemic periodic paralysis. The SCN4A gene provides instructions for making a protein that plays an essential role in muscles used for movement (skeletal muscles). For the body to move normally, these muscles must tense (contract) and relax in a coordinated way. One of the changes that helps trigger muscle contractions is the flow of positively charged atoms (ions), including sodium, into muscle cells. The SCN4A protein forms channels that control the flow of sodium ions into these cells.</p><p>Mutations in the SCN4A gene alter the usual structure and function of sodium channels. The altered channels stay open too long or do not stay closed long enough, allowing more sodium ions to flow into muscle cells. This increase in sodium ions triggers the release of potassium from muscle cells, which causes more sodium channels to open and stimulates the flow of even more sodium ions into these cells. These changes in ion transport reduce the ability of skeletal muscles to contract, leading to episodes of muscle weakness or paralysis.</p><p>In 30 to 40 percent of cases, the cause of hyperkalemic periodic paralysis is unknown. Changes in other genes, which have not been identified, likely cause the disorder in these cases.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/hyperkalemic-periodic-paralysis/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Hyperkalemic periodic paralysis?"},{"bodyHtml":"<p>Most people with hyperkalemic periodic paralysis have increased levels of potassium in their blood (hyperkalemia) during attacks. Hyperkalemia results when the weak or paralyzed muscles release potassium ions into the bloodstream. In other cases, attacks are associated with normal blood potassium levels (normokalemia). Ingesting potassium can trigger attacks in affected individuals, even if blood potassium levels do not go up.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/hyperkalemic-periodic-paralysis\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"hyperkalemic-periodic-paralysis","sourceDocuments":[{"name":"Hyperkalemic periodic paralysis","reviewed":"2013-08","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:18.464827+00:00","label":"Causes","pageSha256":"1d02b81962494fa479b4f24cde04ff78f82fd44fa9f1185a1b3ea52f64af9aba","sourceUrl":"https://medlineplus.gov/genetics/condition/hyperkalemic-periodic-paralysis/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/hyperkalemic-periodic-paralysis"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Hyperkalemic periodic paralysis"},"schemaVersion":1}