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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>The causes of Kawasaki disease are not well understood. The disorder is generally regarded as being the result of an abnormal immune system activation, but the triggers of this abnormal response are unknown. Because cases of the disorder tend to cluster geographically and by season, researchers have suggested that an infection may be involved. However, no infectious agent (such as a virus or bacteria) has been identified.</p><p>A variation in the ITPKC gene has been associated with an increased risk of Kawasaki disease. The ITPKC gene provides instructions for making an enzyme called inositol 1,4,5-trisphosphate 3-kinase C. This enzyme helps limit the activity of immune system cells called T cells. T cells identify foreign substances and defend the body against infection. Reducing the activity of T cells when appropriate prevents the overproduction of immune proteins called cytokines that lead to inflammation and which, in excess, cause tissue damage. Researchers suggest that the ITPKC gene variation may interfere with the body&#x27;s ability to reduce T cell activity, leading to inflammation that damages blood vessels and results in the signs and symptoms of Kawasaki disease.</p><p>It appears likely that other factors, including changes in other genes, also influence the development of this complex disorder.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/kawasaki-disease/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Kawasaki disease?"},{"bodyHtml":"<p>Without treatment, 15 to 25 percent of individuals with Kawasaki disease develop bulging and thinning of the walls of the arteries that supply blood to the heart muscle (coronary artery aneurysms) or other damage to the coronary arteries, which can be life-threatening.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/kawasaki-disease\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"kawasaki-disease","sourceDocuments":[{"name":"Kawasaki disease","reviewed":"2011-06","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:39.936700+00:00","label":"Causes","pageSha256":"d37e531d03415a497a4c86f786629a6e6e8613b6d3a364b7890c0170d4455bfc","sourceUrl":"https://medlineplus.gov/genetics/condition/kawasaki-disease/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/kawasaki-disease"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Kawasaki disease"},"schemaVersion":1}