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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in the MYH7 gene cause Laing distal myopathy. The MYH7 gene provides instructions for making a protein that is found in heart (cardiac) muscle and in type I skeletal muscle fibers. Type I fibers, which are also known as slow-twitch fibers, are one of two types of fibers that make up skeletal muscles. Type I fibers are the primary component of skeletal muscles that are resistant to fatigue. For example, muscles involved in posture, such as the neck muscles that hold the head steady, are made predominantly of type I fibers.</p><p>In cardiac and skeletal muscle cells, the protein produced from the MYH7 gene forms part of a larger protein called type II myosin. This type of myosin generates the mechanical force that is needed for muscles to contract. In the heart, regular contractions of cardiac muscle pump blood to the rest of the body. The coordinated contraction and relaxation of skeletal muscles allow the body to move.</p><p>It is unknown how mutations in the MYH7 gene cause progressive muscle weakness in people with Laing distal myopathy. Researchers have proposed that these mutations alter the structure of myosin in skeletal muscles, which prevents it from interacting with other proteins. The abnormal myosin gradually impairs the function of type I skeletal muscle fibers.</p><p>In most people with Laing distal myopathy, the signs and symptoms of the disorder are limited to weakness of skeletal muscles. Because myosin made with the MYH7 protein is also found in cardiac muscle, it is unclear why heart problems are not a typical feature of this condition.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/laing-distal-myopathy/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Laing distal myopathy?"},{"bodyHtml":"<p>In addition to muscle weakness in the hands and feet, Laing distal myopathy causes weakness in several muscles of the neck and face. A decade or more after the onset of symptoms, mild weakness also spreads to muscles in the legs, hips, and shoulders. Laing distal myopathy progresses very gradually, and most affected people remain mobile throughout life. Life expectancy is normal in people with this condition.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/laing-distal-myopathy\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"laing-distal-myopathy","sourceDocuments":[{"name":"Laing distal myopathy","reviewed":"2008-08","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:47.613046+00:00","label":"Causes","pageSha256":"bf9951328dc4820c844a1f5b9fb06bcc985933dbaf14944709e6a162fbc80d67","sourceUrl":"https://medlineplus.gov/genetics/condition/laing-distal-myopathy/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/laing-distal-myopathy"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Laing distal myopathy"},"schemaVersion":1}