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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Langer mesomelic dysplasia results from changes involving the SHOX gene. The protein produced from this gene plays a role in bone development and is particularly important for the growth and maturation of bones in the arms and legs. The most common cause of Langer mesomelic dysplasia is a deletion of the entire SHOX gene. Other genetic changes that can cause the disorder include mutations in the SHOX gene or deletions of nearby genetic material that normally helps regulate the gene&#x27;s activity. These changes greatly reduce or eliminate the amount of SHOX protein that is produced. A lack of this protein disrupts normal bone development and growth, which underlies the severe skeletal abnormalities associated with Langer mesomelic dysplasia.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/langer-mesomelic-dysplasia/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Langer mesomelic dysplasia?"},{"bodyHtml":"<p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/langer-mesomelic-dysplasia\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"langer-mesomelic-dysplasia","sourceDocuments":[{"name":"Langer mesomelic dysplasia","reviewed":"2012-01","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:48.626525+00:00","label":"Causes","pageSha256":"f0ddbe4017cf368c1e6aad5a972aa8919632eb48e1332d5a033fa1a5e0a8b680","sourceUrl":"https://medlineplus.gov/genetics/condition/langer-mesomelic-dysplasia/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/langer-mesomelic-dysplasia"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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