{"frequencyBands":{"HP:0040280":[100,100],"HP:0040281":[80,99],"HP:0040282":[30,79],"HP:0040283":[5,29],"HP:0040284":[1,4],"HP:0040285":[0,0]},"page":{"columns":[{"gene":"","key":"MONDO:0007481/OMIM:127300","label":"Leri-Weill dyschondrosteosis","mondoId":"MONDO:0007481","onsetQualifier":null,"recordKeys":["05ff198cf9c2e3368ccc463007a8164909e81900ad06a5ff6eac65a0723fb237","122057f15e1dfe6c553d8ede2629be62efe0b648ec73de4e89e44ea9283d86a2","5cf2962fe4b3b9329f2ed7934774ec548bfe7f2f88b7bc3cce2578ae09cf351a","630fa09f149d46c66e08f908dc18baf92b5eb8d08e3600ca25f1e86f84849e80","63500f78a352c25eebc80e9865efbdba82ca93fa96ee370d51f6fbbe87a56aa5","666028de4207bc891ecaa0600185fdc2bdfa313154e230fb88abb2742aa81f60","6fa26d348e633b9cad11c3f6ce5889e58f78a951a6d46507e8aee0683ea02c87","80569d178c1db5cc67d3db1a8479a6fd564d982927ec6dc022bbe28dcac58e49","884b41f2522f981547891688b128d40ade01f327d4a74dd62e79b1cfca7bb4fa","8bb6cf642b6e93d03a8739a77b8a33bd596134e6c2638ecb745b23c159eeedea","9fdf3355715e03b22976cd90fb6ee4081dae94d7c49f030c8309e6fcd5e04cd7","a9d4ade831b4dfc50a202a944b56037b86761da2c92a262adf49a1e7c39947ff","b788a0979a4048205cd9cb63bf3128aa63eb082fe89867e5ae3466add5b4b97a","beba4f03d1d65d5b5ae246cc1e3b34ae8fe1bfcd2d130a32aa1e186f0baeaa9d","c2436b7a155ffdf9e1993b88874b458d2722d147c05cbbf692e6b55aac4fb771","c30014764d5ef5588ec2ef004bb1f3f50bda8b910ffe0f616a87b926a530698c","c8cfb0c163b454dab16eca311827eca832bfe5000f79ada1c6be86b44576e9c0","c9017a6ab5c817e16915214e6f03ef58953b455b32e2258acb23408f69a5f664","d3bfad415aeeeb00cba95291380b655e703ff17b5152ed3f2bdc5c04559cbb22","d7f4d1ede55fcf77c875532d236ea1d64182f5497ccbfeb5e7bdeec1995356b0","eb4dd26b6202dfa291abafc234326fda06b0db917454294ef968d7118ce89e88","ed5a1822d74721ad6024d6419e9fac6ab19244fae49bbd48ee662459d26064dd","f15c78eb12a28aa5165044d52455417f101a49d13628dbae4bf06cc3ccdde81f","fcd21992ec397de11323b5c08fbfa56c4bdc08767a0fa3bdc8a80c947fa9c8b0","fe190c94c47ac699c7c4d1b678001dd2eeabe0e03cf801b4fa5f7986ddda5bce"],"recordQualifiers":{},"scopeLabel":"OMIM:127300","sourceIds":["OMIM:127300"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0007481/ORPHA:240","label":"Léri-Weill dyschondrosteosis","mondoId":"MONDO:0007481","onsetQualifier":null,"recordKeys":["18992c481b3dbc838d95671b4241ad39e43f3a68838bc108c377a2c8bb2835f8","1f8bf5875c0845d5909d60e0e7fa0fb63017ec0dc183b714309e0fa034d89bb2","25a470febb435ddc59f27be011aeb473afa55465efa720413a99378e7eeef9cb","26f1912816650a6093fbe611e50517c2129cb559a89f543aaabb901b3f9a91bd","2dbbb1179fa4814f18afd65ce1d09f03859e36bf4720782951708640f8643ea6","3b105fc48050fb246120c2fa418efe1f9084951b44a02168392d6195a00ce274","47c078c2fed90bfa72743fb6b2e20e383e7a361ecde71296b9ca45209ceaffe0","4eaaaca1438850454a869ffb2945e7fca9be12ac799480e7f554577f2a2a98e8","50ef17729731d1f0865473b824c30bd44c5af1ce019bb8d4348507943ab3a1ef","5a039e84c28bde60d7d1e3ce6151dbc50deba50140c268595e14d09e33b59975","5c0d3862a7bddae0fa96a0d79c76b7591acca2d3ff3ca16e7e53ae214e152694","5c46b7362558400827d146aa9bef4d65a005e4912a2637d844d1b63691dc11fd","674cf255b58ee894d4494beb743ac11ea74d940976948c58aacdc82e5d289dd8","6d5ea818f98e641f86238a6483ce38554fa88421cc4c26e63b04f23b6c93d1fe","7084a240b9a8cfe3a9ca14e2e07e261269c2ad65ecfb1a125f1c3e105aa5bcf2","79d199efd558cb5a283129c2cc714636e817133690a06592730c7bf80b705115","7a58294c9c239d04e2178521034029d4e2d126cb496c959f35860536a396c686","8f5d8fd38e16f95aaac3322b2a36ce68e8476737531c2eafdb4fd57cbe83679c","94460db2c650fb82ee4c679c2ed215ceea866f2990ec3fb9c9ac17a7e2d199fc","95f9fcb94c332dc20ca719f610576115dafcf7a9fcdf7568191374852111422e","996fdca47d14fee19651ba4de59016aff80652e0d41aad96dd1e8ea95c65fb22","9aa269cf09f0c833b62e4ae5f1189c62755846aa3498104f012a3483b1733807","a6311a3700b9cfb3b13c527d641f6bacabec87bbc8f25e6ff17530513d960260","a835e884786c639a51615ed1fc6828f17078018f5c95d42b3b5b5dd961fab7c8","ac43506aee325a195444f01f4bfb779260a68fb326978dffa7081dc75a336659","b0ccfbdc236e25992864942ec96d58e4d47b75208fc1a8c405d2cbf725c8fa2e","bcb2188725df4916cf9a1106308430b40ad07af4ecd27b09de25935ad4e7b85e","bd130cd08f96e11ded9b376cbfc99c3d072d7ead2702cc596d3c02aae29e0d4b","be25dadddbb87739f26c4589bca29027dc21d60717966a664eafed457a298835","bec68598616745cf02c318afbaf2c0b9ec7e4fa6d9edf38994d78d43d5e5e831","c73e6b4ca9948d4aebecf063ca560d14a082fd8e7cf435918a86942bf86d4b4c","ce874aa60a496d3c9896a4e2b27c7ccbce7e6ca5ece71a3e9990ebfbe47cb234","cf4cdd4d53c25ed647dda72ced88dd3130451bd3cb5259dc826a0ebd04bdf17c","ebc83d657b34b44488cff8f75a8c66f3fdb6c12553004fdecfb11bc05266ba1d","ed9f082ee2d6d98b2094711b38b856a0d4ad9c981696075113c82e79522178ec","f7e1a9875bdc477bf1cae16832978831bd3f2b8c004b5ce3e6463e6faad19630","ff12e7f311e8eab2b674e87431adea73a519c5ed2fc7c86e5edbe0888b174b28"],"recordQualifiers":{},"scopeLabel":"ORPHA:240","sourceIds":["ORPHA:240"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."}],"comparison":{"collapseColumnsLabel":"Show initial comparisons","defaultColumnKeys":["MONDO:0007481/OMIM:127300","MONDO:0007481/ORPHA:240"],"expandColumnsLabel":"Compare all source entries","intro":"Compare the original source entries. Different entries may describe different patient groups.","primaryFeatureIds":[],"scopeNoteHtml":"<p>Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.</p>"},"coverage":{"countRecords":0,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":62,"sourceGroups":{"omim":2,"orphanet":37,"other":11,"published":12}},"features":[{"hpoId":"HP:0002683","label":"Abnormal calvaria morphology","primary":false},{"hpoId":"HP:0001191","label":"Abnormal carpal morphology","primary":false},{"hpoId":"HP:0005930","label":"Abnormal epiphysis morphology","primary":false},{"hpoId":"HP:0003367","label":"Abnormal femoral neck morphology","primary":false},{"hpoId":"HP:0002823","label":"Abnormal femur morphology","primary":false},{"hpoId":"HP:0003272","label":"Abnormal hip bone morphology","primary":false},{"hpoId":"HP:0031095","label":"Abnormal humerus morphology","primary":false},{"hpoId":"HP:0005916","label":"Abnormal metacarpal morphology","primary":false},{"hpoId":"HP:0000944","label":"Abnormal metaphysis morphology","primary":false},{"hpoId":"HP:0001832","label":"Abnormal metatarsal morphology","primary":false},{"hpoId":"HP:0002818","label":"Abnormal morphology of the radius","primary":false},{"hpoId":"HP:0040071","label":"Abnormal morphology of ulna","primary":false},{"hpoId":"HP:0002644","label":"Abnormal pelvic girdle bone morphology","primary":false},{"hpoId":"HP:0002992","label":"Abnormal tibia morphology","primary":false},{"hpoId":"HP:0010624","label":"Aplastic/hypoplastic toenail","primary":false},{"hpoId":"HP:0001156","label":"Brachydactyly","primary":false},{"hpoId":"HP:0004209","label":"Clinodactyly of the 5th finger","primary":false},{"hpoId":"HP:0010579","label":"Cone-shaped epiphysis","primary":false},{"hpoId":"HP:0002673","label":"Coxa valga","primary":false},{"hpoId":"HP:0005280","label":"Depressed nasal bridge","primary":false},{"hpoId":"HP:0005019","label":"Diaphyseal undertubulation","primary":false},{"hpoId":"HP:0008873","label":"Disproportionate short-limb short stature","primary":false},{"hpoId":"HP:0006459","label":"Dorsal subluxation of ulna","primary":false},{"hpoId":"HP:0003042","label":"Elbow dislocation","primary":false},{"hpoId":"HP:0100777","label":"Exostoses","primary":false},{"hpoId":"HP:0003038","label":"Fibular hypoplasia","primary":false},{"hpoId":"HP:0002857","label":"Genu valgum","primary":false},{"hpoId":"HP:0002970","label":"Genu varum","primary":false},{"hpoId":"HP:0000218","label":"High palate","primary":false},{"hpoId":"HP:0002984","label":"Hypoplasia of the radius","primary":false},{"hpoId":"HP:0003022","label":"Hypoplasia of the ulna","primary":false},{"hpoId":"HP:0001804","label":"Hypoplastic fingernail","primary":false},{"hpoId":"HP:0003102","label":"Increased carrying angle","primary":false},{"hpoId":"HP:0001387","label":"Joint stiffness","primary":false},{"hpoId":"HP:0002996","label":"Limited elbow movement","primary":false},{"hpoId":"HP:0006248","label":"Limited wrist movement","primary":false},{"hpoId":"HP:0003067","label":"Madelung deformity","primary":false},{"hpoId":"HP:0003027","label":"Mesomelia","primary":false},{"hpoId":"HP:0002983","label":"Micromelia","primary":false},{"hpoId":"HP:0002762","label":"Multiple exostoses","primary":false},{"hpoId":"HP:0006443","label":"Patellar aplasia","primary":false},{"hpoId":"HP:0002986","label":"Radial bowing","primary":false},{"hpoId":"HP:0002650","label":"Scoliosis","primary":false},{"hpoId":"HP:0010044","label":"Short 4th metacarpal","primary":false},{"hpoId":"HP:0005736","label":"Short tibia","primary":false},{"hpoId":"HP:0001831","label":"Short toe","primary":false},{"hpoId":"HP:0003712","label":"Skeletal muscle hypertrophy","primary":false},{"hpoId":"HP:0002982","label":"Tibial bowing","primary":false},{"hpoId":"HP:0003031","label":"Ulnar bowing","primary":false},{"hpoId":"HP:0000431","label":"Wide nasal bridge","primary":false}],"ledeHtml":"Léri-Weill dyschondrosteosis is a disorder of bone growth. Affected individuals typically have shortening of the long bones in the arms and legs (mesomelia). As a result of the shortened leg bones, people with Leri-Weill dyschondrosteosis typically have short stature. Most people with the condition also have an abnormality of the wrist and forearm bones called Madelung deformity, which may cause pain and limit wrist movement. This abnormality usually appears in childhood or early adolescence. Other features of Léri-Weill dyschondrosteosis can include increased muscle mass (muscle hypertrophy); bowing of a bone in the lower leg called the tibia; a greater-than-normal angling of the elbow away from the body (increased carrying angle); and a high arched palate.","mondoId":"MONDO:0007481","records":[{"frequencyKind":"reported","key":"05ff198cf9c2e3368ccc463007a8164909e81900ad06a5ff6eac65a0723fb237","raw":{"aspect":"P","body_system":"growth","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0008873","is_excluded":false,"label":"Disproportionate short-limb short stature","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"reported","key":"122057f15e1dfe6c553d8ede2629be62efe0b648ec73de4e89e44ea9283d86a2","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003712","is_excluded":false,"label":"Skeletal muscle hypertrophy","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"range","key":"18992c481b3dbc838d95671b4241ad39e43f3a68838bc108c377a2c8bb2835f8","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0004209","is_excluded":false,"label":"Clinodactyly of the 5th finger","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"1f8bf5875c0845d5909d60e0e7fa0fb63017ec0dc183b714309e0fa034d89bb2","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002992","is_excluded":false,"label":"Abnormal tibia morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"25a470febb435ddc59f27be011aeb473afa55465efa720413a99378e7eeef9cb","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0005019","is_excluded":false,"label":"Diaphyseal undertubulation","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"26f1912816650a6093fbe611e50517c2129cb559a89f543aaabb901b3f9a91bd","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002823","is_excluded":false,"label":"Abnormal femur morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"2dbbb1179fa4814f18afd65ce1d09f03859e36bf4720782951708640f8643ea6","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0000944","is_excluded":false,"label":"Abnormal metaphysis morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"3b105fc48050fb246120c2fa418efe1f9084951b44a02168392d6195a00ce274","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0002857","is_excluded":false,"label":"Genu valgum","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"47c078c2fed90bfa72743fb6b2e20e383e7a361ecde71296b9ca45209ceaffe0","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0001387","is_excluded":false,"label":"Joint stiffness","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"4eaaaca1438850454a869ffb2945e7fca9be12ac799480e7f554577f2a2a98e8","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0006248","is_excluded":false,"label":"Limited wrist movement","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"50ef17729731d1f0865473b824c30bd44c5af1ce019bb8d4348507943ab3a1ef","raw":{"aspect":"P","body_system":"skin","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0001804","is_excluded":false,"label":"Hypoplastic fingernail","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5a039e84c28bde60d7d1e3ce6151dbc50deba50140c268595e14d09e33b59975","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0005736","is_excluded":false,"label":"Short tibia","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5c0d3862a7bddae0fa96a0d79c76b7591acca2d3ff3ca16e7e53ae214e152694","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0003272","is_excluded":false,"label":"Abnormal hip bone morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5c46b7362558400827d146aa9bef4d65a005e4912a2637d844d1b63691dc11fd","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002986","is_excluded":false,"label":"Radial bowing","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"5cf2962fe4b3b9329f2ed7934774ec548bfe7f2f88b7bc3cce2578ae09cf351a","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0005916","is_excluded":false,"label":"Abnormal metacarpal morphology","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"630fa09f149d46c66e08f908dc18baf92b5eb8d08e3600ca25f1e86f84849e80","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0006248","is_excluded":false,"label":"Limited wrist movement","onset_id":null,"reference":"OMIM:127300","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"63500f78a352c25eebc80e9865efbdba82ca93fa96ee370d51f6fbbe87a56aa5","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003027","is_excluded":false,"label":"Mesomelia","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"reported","key":"666028de4207bc891ecaa0600185fdc2bdfa313154e230fb88abb2742aa81f60","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0010044","is_excluded":false,"label":"Short 4th metacarpal","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"range","key":"674cf255b58ee894d4494beb743ac11ea74d940976948c58aacdc82e5d289dd8","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002644","is_excluded":false,"label":"Abnormal pelvic girdle bone morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"6d5ea818f98e641f86238a6483ce38554fa88421cc4c26e63b04f23b6c93d1fe","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002818","is_excluded":false,"label":"Abnormal morphology of the radius","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"6fa26d348e633b9cad11c3f6ce5889e58f78a951a6d46507e8aee0683ea02c87","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002986","is_excluded":false,"label":"Radial bowing","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"range","key":"7084a240b9a8cfe3a9ca14e2e07e261269c2ad65ecfb1a125f1c3e105aa5bcf2","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0006443","is_excluded":false,"label":"Patellar aplasia","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"79d199efd558cb5a283129c2cc714636e817133690a06592730c7bf80b705115","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002983","is_excluded":false,"label":"Micromelia","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"7a58294c9c239d04e2178521034029d4e2d126cb496c959f35860536a396c686","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0003022","is_excluded":false,"label":"Hypoplasia of the ulna","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"80569d178c1db5cc67d3db1a8479a6fd564d982927ec6dc022bbe28dcac58e49","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0005736","is_excluded":false,"label":"Short tibia","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"884b41f2522f981547891688b128d40ade01f327d4a74dd62e79b1cfca7bb4fa","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003367","is_excluded":false,"label":"Abnormal femoral neck morphology","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"8bb6cf642b6e93d03a8739a77b8a33bd596134e6c2638ecb745b23c159eeedea","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0000218","is_excluded":false,"label":"High palate","onset_id":null,"reference":"PMID:11739418;http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"8f5d8fd38e16f95aaac3322b2a36ce68e8476737531c2eafdb4fd57cbe83679c","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0003042","is_excluded":false,"label":"Elbow dislocation","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"94460db2c650fb82ee4c679c2ed215ceea866f2990ec3fb9c9ac17a7e2d199fc","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0040071","is_excluded":false,"label":"Abnormal morphology of ulna","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"95f9fcb94c332dc20ca719f610576115dafcf7a9fcdf7568191374852111422e","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0000431","is_excluded":false,"label":"Wide nasal bridge","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"996fdca47d14fee19651ba4de59016aff80652e0d41aad96dd1e8ea95c65fb22","raw":{"aspect":"P","body_system":"skin","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0010624","is_excluded":false,"label":"Aplastic/hypoplastic toenail","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"9aa269cf09f0c833b62e4ae5f1189c62755846aa3498104f012a3483b1733807","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002984","is_excluded":false,"label":"Hypoplasia of the radius","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"9fdf3355715e03b22976cd90fb6ee4081dae94d7c49f030c8309e6fcd5e04cd7","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003067","is_excluded":false,"label":"Madelung deformity","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"range","key":"a6311a3700b9cfb3b13c527d641f6bacabec87bbc8f25e6ff17530513d960260","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0100777","is_excluded":false,"label":"Exostoses","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"a835e884786c639a51615ed1fc6828f17078018f5c95d42b3b5b5dd961fab7c8","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0010579","is_excluded":false,"label":"Cone-shaped epiphysis","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"a9d4ade831b4dfc50a202a944b56037b86761da2c92a262adf49a1e7c39947ff","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002650","is_excluded":false,"label":"Scoliosis","onset_id":null,"reference":"PMID:11739418;http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"ac43506aee325a195444f01f4bfb779260a68fb326978dffa7081dc75a336659","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0005280","is_excluded":false,"label":"Depressed nasal bridge","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"b0ccfbdc236e25992864942ec96d58e4d47b75208fc1a8c405d2cbf725c8fa2e","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0006459","is_excluded":false,"label":"Dorsal subluxation of ulna","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"b788a0979a4048205cd9cb63bf3128aa63eb082fe89867e5ae3466add5b4b97a","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001191","is_excluded":false,"label":"Abnormal carpal morphology","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"range","key":"bcb2188725df4916cf9a1106308430b40ad07af4ecd27b09de25935ad4e7b85e","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0003027","is_excluded":false,"label":"Mesomelia","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"bd130cd08f96e11ded9b376cbfc99c3d072d7ead2702cc596d3c02aae29e0d4b","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0001156","is_excluded":false,"label":"Brachydactyly","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"be25dadddbb87739f26c4589bca29027dc21d60717966a664eafed457a298835","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0005930","is_excluded":false,"label":"Abnormal epiphysis morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"beba4f03d1d65d5b5ae246cc1e3b34ae8fe1bfcd2d130a32aa1e186f0baeaa9d","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001832","is_excluded":false,"label":"Abnormal metatarsal morphology","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"bec68598616745cf02c318afbaf2c0b9ec7e4fa6d9edf38994d78d43d5e5e831","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0003031","is_excluded":false,"label":"Ulnar bowing","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"c2436b7a155ffdf9e1993b88874b458d2722d147c05cbbf692e6b55aac4fb771","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002996","is_excluded":false,"label":"Limited elbow movement","onset_id":null,"reference":"OMIM:127300","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"c30014764d5ef5588ec2ef004bb1f3f50bda8b910ffe0f616a87b926a530698c","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003038","is_excluded":false,"label":"Fibular hypoplasia","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"c73e6b4ca9948d4aebecf063ca560d14a082fd8e7cf435918a86942bf86d4b4c","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0002683","is_excluded":false,"label":"Abnormal calvaria morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"c8cfb0c163b454dab16eca311827eca832bfe5000f79ada1c6be86b44576e9c0","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003102","is_excluded":false,"label":"Increased carrying angle","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"reported","key":"c9017a6ab5c817e16915214e6f03ef58953b455b32e2258acb23408f69a5f664","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001831","is_excluded":false,"label":"Short toe","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"ce874aa60a496d3c9896a4e2b27c7ccbce7e6ca5ece71a3e9990ebfbe47cb234","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002982","is_excluded":false,"label":"Tibial bowing","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"cf4cdd4d53c25ed647dda72ced88dd3130451bd3cb5259dc826a0ebd04bdf17c","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0031095","is_excluded":false,"label":"Abnormal humerus morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"d3bfad415aeeeb00cba95291380b655e703ff17b5152ed3f2bdc5c04559cbb22","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002984","is_excluded":false,"label":"Hypoplasia of the radius","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"reported","key":"d7f4d1ede55fcf77c875532d236ea1d64182f5497ccbfeb5e7bdeec1995356b0","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0003022","is_excluded":false,"label":"Hypoplasia of the ulna","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"reported","key":"eb4dd26b6202dfa291abafc234326fda06b0db917454294ef968d7118ce89e88","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002673","is_excluded":false,"label":"Coxa valga","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"ebc83d657b34b44488cff8f75a8c66f3fdb6c12553004fdecfb11bc05266ba1d","raw":{"aspect":"P","body_system":"growth","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0008873","is_excluded":false,"label":"Disproportionate short-limb short stature","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"ed5a1822d74721ad6024d6419e9fac6ab19244fae49bbd48ee662459d26064dd","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002982","is_excluded":false,"label":"Tibial bowing","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"ed9f082ee2d6d98b2094711b38b856a0d4ad9c981696075113c82e79522178ec","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0001191","is_excluded":false,"label":"Abnormal carpal morphology","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"f15c78eb12a28aa5165044d52455417f101a49d13628dbae4bf06cc3ccdde81f","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0031095","is_excluded":false,"label":"Abnormal humerus morphology","onset_id":null,"reference":"ISBN-13:978-0721606156","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"f7e1a9875bdc477bf1cae16832978831bd3f2b8c004b5ce3e6463e6faad19630","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002970","is_excluded":false,"label":"Genu varum","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"fcd21992ec397de11323b5c08fbfa56c4bdc08767a0fa3bdc8a80c947fa9c8b0","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0002762","is_excluded":false,"label":"Multiple exostoses","onset_id":null,"reference":"PMID:11739418;http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"fe190c94c47ac699c7c4d1b678001dd2eeabe0e03cf801b4fa5f7986ddda5bce","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:127300","disease_name":"Leri-Weill dyschondrosteosis","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0006459","is_excluded":false,"label":"Dorsal subluxation of ulna","onset_id":null,"reference":"http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=lwd","source_release":"2026-06-23"},"sourceGroups":["other"]},{"frequencyKind":"range","key":"ff12e7f311e8eab2b674e87431adea73a519c5ed2fc7c86e5edbe0888b174b28","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:240","disease_name":"Léri-Weill dyschondrosteosis","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0003067","is_excluded":false,"label":"Madelung deformity","onset_id":null,"reference":"ORPHA:240","source_release":"2026-06-23"},"sourceGroups":["orphanet"]}],"referenceLabels":{"ISBN-13:978-0721606156":"Jones, 6th ed."},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/leri-weill-dyschondrosteosis\">Léri-Weill dyschondrosteosis</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Most cases of Léri-Weill dyschondrosteosis result from changes involving the SHOX gene. The protein produced from this gene plays a role in bone development and is particularly important for the growth and maturation of bones in the arms and legs. The most common cause of Léri-Weill dyschondrosteosis is a deletion of the entire SHOX gene. Other genetic changes that can cause the disorder include mutations in the SHOX gene or deletions of nearby genetic material that normally helps regulate the gene&#x27;s activity. These changes reduce the amount of SHOX protein that is produced. A shortage of this protein disrupts normal bone development and growth, which underlies the major features of Léri-Weill dyschondrosteosis.</p><p>In affected people who do not have a genetic change involving the SHOX gene, the cause of the condition is unknown.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/leri-weill-dyschondrosteosis/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Léri-Weill dyschondrosteosis?"},{"bodyHtml":"<p>Léri-Weill dyschondrosteosis occurs in both males and females, although its signs and symptoms tend to be more severe in females. Researchers believe that the more severe features may result from hormonal differences.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/leri-weill-dyschondrosteosis\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"leri-weill-dyschondrosteosis","sourceDocuments":[{"name":"Léri-Weill dyschondrosteosis","reviewed":"2012-01","sections":{"causes":{"fetchedAt":"2026-10-20T20:22:53.980385+00:00","label":"Causes","pageSha256":"69ca475a74aeb70c1110d4d8bbd0787e5dd408d47a03f00524189e372607e74c","sourceUrl":"https://medlineplus.gov/genetics/condition/leri-weill-dyschondrosteosis/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/leri-weill-dyschondrosteosis"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Léri-Weill dyschondrosteosis"},"schemaVersion":1}