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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Lymphedema-distichiasis syndrome is caused by mutations in the FOXC2 gene. The FOXC2 gene provides instructions for making a protein that plays a critical role in the formation of many organs and tissues before birth. The FOXC2 protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes. Researchers believe that the FOXC2 protein has a role in a variety of developmental processes, such as the formation of veins and the development of the lungs, eyes, kidneys and urinary tract, cardiovascular system, and the transport system for immune cells (lymphatic vessels).</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/lymphedema-distichiasis-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Lymphedema-distichiasis syndrome?"},{"bodyHtml":"<p>All people with lymphedema-distichiasis syndrome have extra eyelashes present at birth. The age of onset of lymphedema varies, but it most often begins during puberty. Males usually develop lymphedema earlier than females, but all affected individuals will develop lymphedema by the time they are in their forties.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/lymphedema-distichiasis-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"lymphedema-distichiasis-syndrome","sourceDocuments":[{"name":"Lymphedema-distichiasis syndrome","reviewed":"2008-02","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:01.010548+00:00","label":"Causes","pageSha256":"3aa93875ffc4a0103028e3c90cb7ebde243528acd5cb7084f2a845630388082c","sourceUrl":"https://medlineplus.gov/genetics/condition/lymphedema-distichiasis-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/lymphedema-distichiasis-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Lymphedema-distichiasis syndrome"},"schemaVersion":1}