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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in the FLT4 gene cause some cases of Milroy disease. The FLT4 gene provides instructions for producing a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic system. Mutations in the FLT4 gene interfere with the growth, movement, and survival of cells that line the lymphatic vessels (lymphatic endothelial cells). These mutations lead to the development of small or absent lymphatic vessels. If lymph fluid is not properly transported, it builds up in the body&#x27;s tissues and causes lymphedema. It is not known how mutations in the FLT4 gene lead to the other features of this disorder.</p><p>Many individuals with Milroy disease do not have a mutation in the FLT4 gene. In these individuals, the cause of the disorder is unknown.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/milroy-disease/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Milroy disease?"},{"bodyHtml":"<p>Milroy disease is associated with other features in addition to lymphedema. Males with Milroy disease are sometimes born with an accumulation of fluid in the scrotum (hydrocele). Males and females may have upslanting toenails, deep creases in the toes, wart-like growths (papillomas), and prominent leg veins. Some individuals develop non-contagious skin infections called cellulitis that can damage the thin tubes that carry lymph fluid (lymphatic vessels). Episodes of cellulitis can cause further swelling in the lower limbs.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/milroy-disease\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"milroy-disease","sourceDocuments":[{"name":"Milroy disease","reviewed":"2008-05","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:21.484709+00:00","label":"Causes","pageSha256":"421a209331ac28c67b947d168816ecf96b965782806de91289d354baaed6a1e7","sourceUrl":"https://medlineplus.gov/genetics/condition/milroy-disease/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/milroy-disease"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Milroy disease"},"schemaVersion":1}