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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>A particular mutation in the FGFR3 gene causes Muenke syndrome. The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. The mutation associated with Muenke syndrome causes the FGFR3 protein to be overly active, which interferes with normal bone growth and allows the bones of the skull to fuse before they should.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/muenke-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Muenke syndrome?"},{"bodyHtml":"<p>Many people with this disorder have a premature fusion of skull bones along the coronal suture, the growth line that goes over the head from ear to ear. Other parts of the skull may also be malformed. These changes can result in an abnormally shaped head, wide-set eyes, and flattened cheekbones. About 5 percent of affected individuals have an enlarged head (macrocephaly). People with Muenke syndrome may also have mild abnormalities of the hands or feet, and hearing loss has been observed in some cases. Most people with this condition have normal intellect, but developmental delay and learning problems are possible.</p><p>The signs and symptoms of Muenke syndrome vary among affected people, and some features overlap with those seen in other craniosynostosis syndromes. A small percentage of people with the gene mutation associated with Muenke syndrome do not have any of the characteristic features of the disorder.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/muenke-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"muenke-syndrome","sourceDocuments":[{"name":"Muenke syndrome","reviewed":"2006-06","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:30.901599+00:00","label":"Causes","pageSha256":"bec8b7bc7e9760a59c3fc45db58c224c5e1b95fc3b7595dd3ecc467146e543c9","sourceUrl":"https://medlineplus.gov/genetics/condition/muenke-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/muenke-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Muenke syndrome"},"schemaVersion":1}