{"frequencyBands":{"HP:0040280":[100,100],"HP:0040281":[80,99],"HP:0040282":[30,79],"HP:0040283":[5,29],"HP:0040284":[1,4],"HP:0040285":[0,0]},"page":{"columns":[{"gene":"","key":"MONDO:0009809/OMIM:259600","label":"Multicentric osteolysis, nodulosis, and arthropathy","mondoId":"MONDO:0009809","onsetQualifier":null,"recordKeys":["07bb9d4c137bfcd3035d1ed8843500f59c81ba37d2f39418cf9bbd45f4b0aede","083c5e87e043ef6b978aeb2c8125890a6a4458c9d3f9cc323abc4b4f9b7b8c90","0b06b2ac833700ff5992bd5d03dcd4050a59965a83ae93837128551f1e83f210","0b5c96bc18dab8cb563d98cef061feea511482622348d6e15f62aab505346268","17c93da4b36218165fde3c8506454774f60ea0f39bfbaf8500cf9b06f762388f","19efa03a0f89172ee3b6615e64b03ace42b0fd28d5d6b5532aaefcd19200d62f","1e325322887d3cfc9f39e72a86a94523034cfdce376f4c40f147835dfb203942","27953c4821cb9793cf3e1c3c2b349fd77df470f72b7ee805035e5b64eaef4499","289d4042670c8a44e63cd271dc615b02eacda6e307fa8d2efc4beb88b468607a","3177bb7f34e0b7445da0b332cbf7113341dded89249b20307ca4a7faebd6327b","341a0101c17243f5df00229d72d7312ae43fa083f17228b0916008b399931d3a","38f519c7fc64fce0aff9d1ff339595edda215267d2bcb9bcfcbce4a83d8bdf19","3e1ab31dcf7a352d8dc6eb225df08645b79de42d86eb9c7e198685f9da7c3046","3ec112cf3429bef26819db591ffafd22e1adbaf3be190063d2b1e3a3d6dc51d0","4259e53fb83ce792975101cf2e4e13e682ff72de681aec7c49d1e8a0d013d11a","437a7ff57c72e69e91441150222bcbc41fb39dea73205c0472373a6950a0a7f1","460702ae5f87f6be0e61ddc75225bfef8e74967e3d64f14a0024cbf7e6352042","46c55088868d5d2894b3ebc0e3c8887afdd1b13ed43de4128d9f54772f4aa0fe","54d028929e0175bc6c1a8cabcc4891ff58c330683db5204747c6b7eec33c1d86","595ebe1c05b9d33f65651d02c63f8986968dc8c63a0085b85a57704ce19ae535","631cebe8c04527427bb80d369f8e35778f8720e3669a373e954e5f434341beb7","6c2dac7fb6d9e673cd321f82e89a50c435a57bbba4bc8fef05ee639f514b46e2","72024af66a0a6abaeeabb6f2c450e0db69cf8842998490cac42d72e402982e6a","7c751d49527958575a9a6b62831302e42eb940b50ef1e885fd7d3f7c95528676","83639b06063fe9000788d1202abd58f9eb2342af18197488fd92e26644c2c9c0","88275fbb6559b8f73939ae4f8c6566e05837f50efaf506b88f984455d58e7b71","8a87d03f398d4e7dff6bc1962ec4424c99c58016eb354142c0017c98a6295a00","8cbbcacc22bf0dd690f56325ebfb8616aa48913351cd9ec728f1254b7cd631b6","8e3a4ade6cbf62d865e8eec7760cf10c96c088d2e75b9445676c72e68df45836","8ec7c3b374bace4dca973f6d137ddb2daa4b2ad9d4a6698e1023698eee72af95","9be1b7807ec258ec3d10c3233714aa989012a1732c1e206237c6da18718b54d7","a590e419964a6dc2d0d517a1759f71aac1323e0579eed2a76bf2b789f21ae8d9","b95bc8867b719a07e613b0433bfd605945060f92ef8ef2a2eb25b1242ab81072","bad5ba05f240eb8a023fc4177bf4d65f6e362bd2c0561b2e8d55538c6b10ad8f","bb849afade469c59e50262f7b820144fda9a6b8befc9b54ea8cace5db067ae11","bdd2f336a72ff64e512e722a7f08a84017bcc3a1e3c95fe9e8d7addcfb4a67e9","beafd63d536c89533fd74422090eee618fae35f38d7036c439f526bd9ce760ca","beb63f5e3a4d6a77c9d6862f531d992e76793ed4c7a50aef1a355e394cc0824e","c0faaed0836f11ef87654868ec40cb1b61c7ae0b45c49fec731dbb8f4ce83fe0","c55c220115a4a2ae77d918500a06107408017f5f2b647bac8fe5b49236bc02ac","cf50bfa88618810c3c7164b645b50766421a18ac8047b73435ab04f83b093175","d55b9c7961926e7c77a379d664fa34f85ad84984e6b0f2e50c3e2ead98145424","d7ff73d6b54eb0f00bdb5850919f2ebf62ccf884c6a1b3b9335aaf6e8d579cc9","e019019925a1af56b779298bcec10bf4f171051d659b5e46c64782e73f51e5cf","e3314469513ede7b57d0a20406d3b0d8fbb31c1fbc69568f7043196700e024a4","edaa880f7136693325eff48493e21399f817052d336c22702adb8c5f22e75016","f0532c706e538f556be4b293f0906205e41d68a75cc9d330c2ecc2cd95b1b837","f1350a68bbf4e91cd9df821c2442fe70e5a00e6ebb9fec018419d6ace6d309fb","f15f9d77bf549c950c895a9c4e0e0f9c985402d5f3d21a0d3964267762e8d26e","f176d5231f385dc3862ca478c160744d31766ba623f53008939f3c63826ab925","f27f4fcfda6528939893abb99c7aa13b9e427359828307e9ceaf9835624cf24f","f5da36ea81fd9c96c5abd4d1813fafc8db05218878c28d76c430cd8be273c15b","f8143ce8975e4cef1e1d87a0cf26da7d8a47dff26e40b098bdc9fd3507160181","fe37482f1933d1eb7e112434ce892eac06585fcd2f962ec1f19bed2c77d15faf"],"recordQualifiers":{},"scopeLabel":"OMIM:259600","sourceIds":["OMIM:259600"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."}],"comparison":{"collapseColumnsLabel":"Show initial comparisons","defaultColumnKeys":["MONDO:0009809/OMIM:259600"],"expandColumnsLabel":"Compare all source entries","intro":"Compare the original source entries. Different entries may describe different patient groups.","primaryFeatureIds":[],"scopeNoteHtml":"<p>Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.</p>"},"coverage":{"countRecords":25,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":54,"sourceGroups":{"omim":29,"orphanet":0,"published":25}},"features":[{"hpoId":"HP:0006466","label":"Ankle flexion contracture","primary":false},{"hpoId":"HP:0008090","label":"Ankylosis of feet small joints","primary":false},{"hpoId":"HP:0003493","label":"Antinuclear antibody positivity","primary":false},{"hpoId":"HP:0002829","label":"Arthralgia","primary":false},{"hpoId":"HP:0000248","label":"Brachycephaly","primary":false},{"hpoId":"HP:0001230","label":"Broad metacarpals","primary":false},{"hpoId":"HP:0001783","label":"Broad metatarsal","primary":false},{"hpoId":"HP:0000414","label":"Bulbous nose","primary":false},{"hpoId":"HP:0003320","label":"C1-C2 subluxation","primary":false},{"hpoId":"HP:0001836","label":"Camptodactyly of toe","primary":false},{"hpoId":"HP:0001495","label":"Carpal osteolysis","primary":false},{"hpoId":"HP:0000280","label":"Coarse facial features","primary":false},{"hpoId":"HP:0007957","label":"Corneal opacity","primary":false},{"hpoId":"HP:0001476","label":"Delayed closure of the anterior fontanelle","primary":false},{"hpoId":"HP:0000684","label":"Delayed eruption of teeth","primary":false},{"hpoId":"HP:0008133","label":"Distal tapering of metatarsals","primary":false},{"hpoId":"HP:0025131","label":"Finger swelling","primary":false},{"hpoId":"HP:0002007","label":"Frontal bossing","primary":false},{"hpoId":"HP:0001288","label":"Gait disturbance","primary":false},{"hpoId":"HP:0000212","label":"Gingival overgrowth","primary":false},{"hpoId":"HP:0003273","label":"Hip contracture","primary":false},{"hpoId":"HP:0001007","label":"Hirsutism","primary":false},{"hpoId":"HP:0001034","label":"Hypermelanotic macule","primary":false},{"hpoId":"HP:0000316","label":"Hypertelorism","primary":false},{"hpoId":"HP:0000327","label":"Hypoplasia of the maxilla","primary":false},{"hpoId":"HP:0001220","label":"Interphalangeal joint contracture of finger","primary":false},{"hpoId":"HP:0006252","label":"Interphalangeal joint erosions","primary":false},{"hpoId":"HP:0002751","label":"Kyphoscoliosis","primary":false},{"hpoId":"HP:0001504","label":"Metacarpal osteolysis","primary":false},{"hpoId":"HP:0003016","label":"Metaphyseal widening","primary":false},{"hpoId":"HP:0001473","label":"Metatarsal osteolysis","primary":false},{"hpoId":"HP:0000347","label":"Micrognathia","primary":false},{"hpoId":"HP:0001634","label":"Mitral valve prolapse","primary":false},{"hpoId":"HP:0000446","label":"Narrow nasal bridge","primary":false},{"hpoId":"HP:0006234","label":"Osteolysis involving tarsal bones","primary":false},{"hpoId":"HP:0000938","label":"Osteopenia","primary":false},{"hpoId":"HP:0000939","label":"Osteoporosis","primary":false},{"hpoId":"HP:0008011","label":"Peripheral opacification of the cornea","primary":false},{"hpoId":"HP:0001761","label":"Pes cavus","primary":false},{"hpoId":"HP:0001763","label":"Pes planus","primary":false},{"hpoId":"HP:0000520","label":"Proptosis","primary":false},{"hpoId":"HP:0003179","label":"Protrusio acetabuli","primary":false},{"hpoId":"HP:0005441","label":"Sclerotic cranial sutures","primary":false},{"hpoId":"HP:0004322","label":"Short stature","primary":false},{"hpoId":"HP:0001171","label":"Split hand","primary":false},{"hpoId":"HP:0001482","label":"Subcutaneous nodule","primary":false},{"hpoId":"HP:0001072","label":"Thickened skin","primary":false},{"hpoId":"HP:0002753","label":"Thin bony cortex","primary":false},{"hpoId":"HP:0006086","label":"Thin metacarpal cortices","primary":false},{"hpoId":"HP:0008078","label":"Thin metatarsal cortices","primary":false},{"hpoId":"HP:0002953","label":"Vertebral compression fracture","primary":false},{"hpoId":"HP:0010537","label":"Wide cranial sutures","primary":false},{"hpoId":"HP:0006012","label":"Widened metacarpal shaft","primary":false},{"hpoId":"HP:0001239","label":"Wrist flexion contracture","primary":false}],"ledeHtml":"Multicentric osteolysis, nodulosis, and arthropathy (MONA) describes a rare inherited disease characterized by a loss of bone tissue (osteolysis), particularly in the hands and feet. MONA includes a condition formerly called nodulosis-arthropathy-osteolysis (NAO) syndrome. It may also include a similar disorder called Torg syndrome, although it is unknown whether Torg syndrome is actually part of MONA or a separate disorder caused by a mutation in a different gene.","mondoId":"MONDO:0009809","records":[{"frequencyKind":"reported","key":"07bb9d4c137bfcd3035d1ed8843500f59c81ba37d2f39418cf9bbd45f4b0aede","raw":{"aspect":"P","body_system":"skin","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001072","is_excluded":false,"label":"Thickened skin","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"083c5e87e043ef6b978aeb2c8125890a6a4458c9d3f9cc323abc4b4f9b7b8c90","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0002753","is_excluded":false,"label":"Thin bony cortex","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"0b06b2ac833700ff5992bd5d03dcd4050a59965a83ae93837128551f1e83f210","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0006252","is_excluded":false,"label":"Interphalangeal joint erosions","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"0b5c96bc18dab8cb563d98cef061feea511482622348d6e15f62aab505346268","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0008078","is_excluded":false,"label":"Thin metatarsal cortices","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"17c93da4b36218165fde3c8506454774f60ea0f39bfbaf8500cf9b06f762388f","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"2/5","hpo_id":"HP:0001495","is_excluded":false,"label":"Carpal osteolysis","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"19efa03a0f89172ee3b6615e64b03ace42b0fd28d5d6b5532aaefcd19200d62f","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"4/5","hpo_id":"HP:0000212","is_excluded":false,"label":"Gingival overgrowth","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"1e325322887d3cfc9f39e72a86a94523034cfdce376f4c40f147835dfb203942","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"2/5","hpo_id":"HP:0002751","is_excluded":false,"label":"Kyphoscoliosis","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"27953c4821cb9793cf3e1c3c2b349fd77df470f72b7ee805035e5b64eaef4499","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0006466","is_excluded":false,"label":"Ankle flexion contracture","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"289d4042670c8a44e63cd271dc615b02eacda6e307fa8d2efc4beb88b468607a","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0008133","is_excluded":false,"label":"Distal tapering of metatarsals","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"3177bb7f34e0b7445da0b332cbf7113341dded89249b20307ca4a7faebd6327b","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0025131","is_excluded":false,"label":"Finger swelling","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"341a0101c17243f5df00229d72d7312ae43fa083f17228b0916008b399931d3a","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001171","is_excluded":false,"label":"Split hand","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"38f519c7fc64fce0aff9d1ff339595edda215267d2bcb9bcfcbce4a83d8bdf19","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001836","is_excluded":false,"label":"Camptodactyly of toe","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"3e1ab31dcf7a352d8dc6eb225df08645b79de42d86eb9c7e198685f9da7c3046","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"5/5","hpo_id":"HP:0000414","is_excluded":false,"label":"Bulbous nose","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"3ec112cf3429bef26819db591ffafd22e1adbaf3be190063d2b1e3a3d6dc51d0","raw":{"aspect":"P","body_system":"other","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0002829","is_excluded":false,"label":"Arthralgia","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"4259e53fb83ce792975101cf2e4e13e682ff72de681aec7c49d1e8a0d013d11a","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"2/5","hpo_id":"HP:0003320","is_excluded":false,"label":"C1-C2 subluxation","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"437a7ff57c72e69e91441150222bcbc41fb39dea73205c0472373a6950a0a7f1","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/5","hpo_id":"HP:0001634","is_excluded":false,"label":"Mitral valve prolapse","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"460702ae5f87f6be0e61ddc75225bfef8e74967e3d64f14a0024cbf7e6352042","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"2/5","hpo_id":"HP:0007957","is_excluded":false,"label":"Corneal opacity","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"46c55088868d5d2894b3ebc0e3c8887afdd1b13ed43de4128d9f54772f4aa0fe","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000684","is_excluded":false,"label":"Delayed eruption of teeth","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"54d028929e0175bc6c1a8cabcc4891ff58c330683db5204747c6b7eec33c1d86","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001761","is_excluded":false,"label":"Pes cavus","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"595ebe1c05b9d33f65651d02c63f8986968dc8c63a0085b85a57704ce19ae535","raw":{"aspect":"P","body_system":"skin","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001034","is_excluded":false,"label":"Hypermelanotic macule","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"631cebe8c04527427bb80d369f8e35778f8720e3669a373e954e5f434341beb7","raw":{"aspect":"P","body_system":"immune","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0003493","is_excluded":false,"label":"Antinuclear antibody positivity","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"6c2dac7fb6d9e673cd321f82e89a50c435a57bbba4bc8fef05ee639f514b46e2","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001763","is_excluded":false,"label":"Pes planus","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"72024af66a0a6abaeeabb6f2c450e0db69cf8842998490cac42d72e402982e6a","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0005441","is_excluded":false,"label":"Sclerotic cranial sutures","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"7c751d49527958575a9a6b62831302e42eb940b50ef1e885fd7d3f7c95528676","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0001288","is_excluded":false,"label":"Gait disturbance","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"83639b06063fe9000788d1202abd58f9eb2342af18197488fd92e26644c2c9c0","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000446","is_excluded":false,"label":"Narrow nasal bridge","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"88275fbb6559b8f73939ae4f8c6566e05837f50efaf506b88f984455d58e7b71","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000316","is_excluded":false,"label":"Hypertelorism","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"8a87d03f398d4e7dff6bc1962ec4424c99c58016eb354142c0017c98a6295a00","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0006012","is_excluded":false,"label":"Widened metacarpal shaft","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"8cbbcacc22bf0dd690f56325ebfb8616aa48913351cd9ec728f1254b7cd631b6","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0003179","is_excluded":false,"label":"Protrusio acetabuli","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"8e3a4ade6cbf62d865e8eec7760cf10c96c088d2e75b9445676c72e68df45836","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000938","is_excluded":false,"label":"Osteopenia","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"8ec7c3b374bace4dca973f6d137ddb2daa4b2ad9d4a6698e1023698eee72af95","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000248","is_excluded":false,"label":"Brachycephaly","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"9be1b7807ec258ec3d10c3233714aa989012a1732c1e206237c6da18718b54d7","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000520","is_excluded":false,"label":"Proptosis","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"a590e419964a6dc2d0d517a1759f71aac1323e0579eed2a76bf2b789f21ae8d9","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001239","is_excluded":false,"label":"Wrist flexion contracture","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"b95bc8867b719a07e613b0433bfd605945060f92ef8ef2a2eb25b1242ab81072","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0006234","is_excluded":false,"label":"Osteolysis involving tarsal bones","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"bad5ba05f240eb8a023fc4177bf4d65f6e362bd2c0561b2e8d55538c6b10ad8f","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0002007","is_excluded":false,"label":"Frontal bossing","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"bb849afade469c59e50262f7b820144fda9a6b8befc9b54ea8cace5db067ae11","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0001473","is_excluded":false,"label":"Metatarsal osteolysis","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"bdd2f336a72ff64e512e722a7f08a84017bcc3a1e3c95fe9e8d7addcfb4a67e9","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0001504","is_excluded":false,"label":"Metacarpal osteolysis","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"beafd63d536c89533fd74422090eee618fae35f38d7036c439f526bd9ce760ca","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0001220","is_excluded":false,"label":"Interphalangeal joint contracture of finger","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"beb63f5e3a4d6a77c9d6862f531d992e76793ed4c7a50aef1a355e394cc0824e","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0008090","is_excluded":false,"label":"Ankylosis of feet small joints","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"c0faaed0836f11ef87654868ec40cb1b61c7ae0b45c49fec731dbb8f4ce83fe0","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0002953","is_excluded":false,"label":"Vertebral compression fracture","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"c55c220115a4a2ae77d918500a06107408017f5f2b647bac8fe5b49236bc02ac","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0001230","is_excluded":false,"label":"Broad metacarpals","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"cf50bfa88618810c3c7164b645b50766421a18ac8047b73435ab04f83b093175","raw":{"aspect":"P","body_system":"skin","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"3/3","hpo_id":"HP:0001007","is_excluded":false,"label":"Hirsutism","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"d55b9c7961926e7c77a379d664fa34f85ad84984e6b0f2e50c3e2ead98145424","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"11/11","hpo_id":"HP:0001783","is_excluded":false,"label":"Broad metatarsal","onset_id":null,"reference":"OMIM:259600;PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"d7ff73d6b54eb0f00bdb5850919f2ebf62ccf884c6a1b3b9335aaf6e8d579cc9","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000347","is_excluded":false,"label":"Micrognathia","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"e019019925a1af56b779298bcec10bf4f171051d659b5e46c64782e73f51e5cf","raw":{"aspect":"P","body_system":"growth","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0004322","is_excluded":false,"label":"Short stature","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"e3314469513ede7b57d0a20406d3b0d8fbb31c1fbc69568f7043196700e024a4","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000939","is_excluded":false,"label":"Osteoporosis","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"edaa880f7136693325eff48493e21399f817052d336c22702adb8c5f22e75016","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0008011","is_excluded":false,"label":"Peripheral opacification of the cornea","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"f0532c706e538f556be4b293f0906205e41d68a75cc9d330c2ecc2cd95b1b837","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001476","is_excluded":false,"label":"Delayed closure of the anterior fontanelle","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"f1350a68bbf4e91cd9df821c2442fe70e5a00e6ebb9fec018419d6ace6d309fb","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"5/5","hpo_id":"HP:0000280","is_excluded":false,"label":"Coarse facial features","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"f15f9d77bf549c950c895a9c4e0e0f9c985402d5f3d21a0d3964267762e8d26e","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0003016","is_excluded":false,"label":"Metaphyseal widening","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"f176d5231f385dc3862ca478c160744d31766ba623f53008939f3c63826ab925","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000327","is_excluded":false,"label":"Hypoplasia of the maxilla","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"f27f4fcfda6528939893abb99c7aa13b9e427359828307e9ceaf9835624cf24f","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0006086","is_excluded":false,"label":"Thin metacarpal cortices","onset_id":null,"reference":"PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"f5da36ea81fd9c96c5abd4d1813fafc8db05218878c28d76c430cd8be273c15b","raw":{"aspect":"P","body_system":"skin","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"2/6","hpo_id":"HP:0001482","is_excluded":false,"label":"Subcutaneous nodule","onset_id":null,"reference":"PMID:24637309;PMID:17059372","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"f8143ce8975e4cef1e1d87a0cf26da7d8a47dff26e40b098bdc9fd3507160181","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0003273","is_excluded":false,"label":"Hip contracture","onset_id":null,"reference":"OMIM:259600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"fe37482f1933d1eb7e112434ce892eac06585fcd2f962ec1f19bed2c77d15faf","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:259600","disease_name":"Multicentric osteolysis, nodulosis, and arthropathy","evidence":"PCS","frequency_raw":"2/5","hpo_id":"HP:0010537","is_excluded":false,"label":"Wide cranial sutures","onset_id":null,"reference":"PMID:24637309","source_release":"2026-06-23"},"sourceGroups":["published"]}],"referenceLabels":{},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/multicentric-osteolysis-nodulosis-and-arthropathy\">Multicentric osteolysis, nodulosis, and arthropathy</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>MONA results from mutations in the MMP2 gene. This gene provides instructions for making an enzyme called matrix metallopeptidase 2, whose primary function is to cut (cleave) a protein called type IV collagen. Type IV collagen is a major structural component of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. The activity of matrix metallopeptidase 2 appears to be important for a variety of body functions, including bone remodeling, which is a normal process in which old bone is broken down and new bone is created to replace it.</p><p>The MMP2 gene mutations that cause MONA completely eliminate the activity of the matrix metallopeptidase 2 enzyme, preventing the normal cleavage of type IV collagen. It is unclear how a loss of enzyme activity leads to the specific features of MONA. Researchers suspect that it somehow disrupts the balance of new bone creation and the breakdown of existing bone during bone remodeling, resulting in a progressive loss of bone tissue. How a shortage of matrix metallopeptidase 2 leads to the other features of MONA, such as subcutaneous nodules and skin abnormalities, is unknown.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/multicentric-osteolysis-nodulosis-and-arthropathy/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Multicentric osteolysis, nodulosis, and arthropathy?"},{"bodyHtml":"<p>In most cases of MONA, bone loss begins in the hands and feet, causing pain and limiting movement. Bone abnormalities can later spread to other areas of the body, with joint problems (arthropathy) occurring in the elbows, shoulders, knees, hips, and spine. Most people with MONA develop low bone mineral density (osteopenia) and thinning of the bones (osteoporosis) throughout the skeleton. These abnormalities make bones brittle and more prone to fracture. The bone abnormalities also lead to short stature.</p><p>Many affected individuals develop subcutaneous nodules, which are firm lumps of noncancerous tissue underneath the skin, especially on the soles of the feet. Some affected individuals also have skin abnormalities including patches of dark, thick, and leathery skin. Other features of MONA can include clouding of the clear front covering of the eye (corneal opacity), excess hair growth (hypertrichosis), overgrowth of the gums, heart abnormalities, and distinctive facial features that are described as &quot;coarse.&quot;</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/multicentric-osteolysis-nodulosis-and-arthropathy\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"multicentric-osteolysis-nodulosis-and-arthropathy","sourceDocuments":[{"name":"Multicentric osteolysis, nodulosis, and arthropathy","reviewed":"2013-11","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:31.576448+00:00","label":"Causes","pageSha256":"2508caa3c5226876d08f97037f411dbe56d994b0bb5553efdb58783cefbe2d00","sourceUrl":"https://medlineplus.gov/genetics/condition/multicentric-osteolysis-nodulosis-and-arthropathy/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/multicentric-osteolysis-nodulosis-and-arthropathy"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Multicentric osteolysis, nodulosis, and arthropathy"},"schemaVersion":1}