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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in several genes can cause NBCIE. Mutations in the ABCA12, ALOX12B, or ALOXE3 gene are responsible for most of cases of NBCIE. Mutations in other genes are each found in only a small percentage of cases. All of the genes associated with NBCIE provide instructions for making proteins that are found in the outermost layer of the skin (the epidermis). The epidermis forms a protective barrier between the body and its surrounding environment. Gene mutations impair the respective protein&#x27;s function or structure within the epidermis, which prevents this outermost layer of skin from being an effective barrier before and after birth. The abnormal skin cannot protect against fluid loss (dehydration) or the outside environment, leading to problems controlling body temperature; dry skin; the formation of fine, white scales; and increased risk of infections in people with NBCIE. The skin scales can impair the function of sweat glands under the skin, causing anhidrosis.</p><p>In some people with NBCIE, the cause of the disorder is unknown. Researchers are looking for additional genes that are associated with NBCIE.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/nonbullous-congenital-ichthyosiform-erythroderma/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Nonbullous congenital ichthyosiform erythroderma?"},{"bodyHtml":"<p>Some people with NBCIE have thickening of the skin on the palms of the hands and soles of the feet (palmoplantar keratoderma), decreased or absent sweating (anhidrosis), and abnormal nails (nail dystrophy). In severe cases, there is an absence of hair growth (alopecia) in certain areas, often affecting the scalp and eyebrows.</p><p>In individuals with NBCIE, some of the skin problems may improve by adulthood. Life expectancy is normal in people with NBCIE.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/nonbullous-congenital-ichthyosiform-erythroderma\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"nonbullous-congenital-ichthyosiform-erythroderma","sourceDocuments":[{"name":"Nonbullous congenital ichthyosiform erythroderma","reviewed":"2017-07","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:47.931529+00:00","label":"Causes","pageSha256":"452586b8db2823a65168be23f74969ba39fa09fa92ced981989b186f2cfa6af5","sourceUrl":"https://medlineplus.gov/genetics/condition/nonbullous-congenital-ichthyosiform-erythroderma/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/nonbullous-congenital-ichthyosiform-erythroderma"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Nonbullous congenital ichthyosiform erythroderma"},"schemaVersion":1}