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dermatitis","onset_id":null,"reference":"ORPHA:79153","source_release":"2026-06-23"},"sourceGroups":["orphanet"]}],"referenceLabels":{},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/nonsyndromic-congenital-nail-disorder-10\">Nonsyndromic congenital nail disorder 10</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Nonsyndromic congenital nail disorder 10 is caused by mutations in the FZD6 gene, which provides instructions for making a protein called frizzled-6. This protein is embedded in the outer membrane of many types of cells, where it is involved in transmitting chemical signals from outside the cell to the cell&#x27;s nucleus. The frizzled-6 protein plays an especially critical role in the growth and development of nails, particularly the attachment of the nail to the nail bed.</p><p>FZD6 gene mutations that cause nonsyndromic congenital nail disorder 10 lead to the production of a frizzled-6 protein that cannot get to the cell membrane where it is needed or that cannot transmit signals into the cell. As a result, the growth and development of nails is poorly regulated, which leads to onycholysis and other abnormalities of the fingernails and toenails.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/nonsyndromic-congenital-nail-disorder-10/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Nonsyndromic congenital nail disorder 10?"},{"bodyHtml":"<p>In affected individuals, the nails are often abnormal from birth. However, the abnormalities may not be noticeable until later in childhood because the nails tend to grow more slowly than normal.</p><p>Individuals with nonsyndromic congenital nail disorder 10 do not have any other health problems related to the condition.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/nonsyndromic-congenital-nail-disorder-10\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"nonsyndromic-congenital-nail-disorder-10","sourceDocuments":[{"name":"Nonsyndromic congenital nail disorder 10","reviewed":"2017-03","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:48.888087+00:00","label":"Causes","pageSha256":"7b4bd64f0c4885d2785bc0f16799b8c823e69c395ae7f3578bf0189057c89275","sourceUrl":"https://medlineplus.gov/genetics/condition/nonsyndromic-congenital-nail-disorder-10/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/nonsyndromic-congenital-nail-disorder-10"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Nonsyndromic congenital nail disorder 10"},"schemaVersion":1}