{"frequencyBands":{"HP:0040280":[100,100],"HP:0040281":[80,99],"HP:0040282":[30,79],"HP:0040283":[5,29],"HP:0040284":[1,4],"HP:0040285":[0,0]},"page":{"columns":[{"gene":"","key":"MONDO:0008145/OMIM:166000","label":"Enchondromatosis, multiple","mondoId":"MONDO:0008145","onsetQualifier":null,"recordKeys":["75e1e78c7d90a2e75f3bc0abe9c02944dd6693023097c263368f353993f6f480","9e7d861f75f72fda29fe84cc055d07d3442c7ce5b570d5f1cbe3b03ee1ac0bcb","bda4ea27e8a7cfbe58d5faca99d1c2f11fcfc6caa7feb22fa7522ef6feb3dda5","c6a63cc17d7a4cc3e321bccc2f3fa4bc0f87296be9c81e07466dd49c37ee3c79"],"recordQualifiers":{},"scopeLabel":"OMIM:166000","sourceIds":["OMIM:166000"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0008145/ORPHA:296","label":"Ollier disease","mondoId":"MONDO:0008145","onsetQualifier":null,"recordKeys":["09e7ddf9d48b2f8b49e90f408ff12b7ccc42bcc75b9b87b626bd836ea94a0e8c","18a350b477676b1ee42e5440962665574a6f32d22a52dc1e4644ce9f4dc71c48","1f3e89f092dbdc07e056c82cb64dfb5297806b34d2918a0d8c197a8ac24303a0","1ff5b55a22dcca33664b4afe55a53acdc2553e2aaffd82174d1ef20383b0d4e9","216631917ee2e549225cf75e1f52ba2ddf6a1f3caf45e7ec6d4201bd2341c596","2e8abc8658ff5ce3dd6a7eff0677fcd6c45c8b4075c57b3847a01335e008279a","2ef56b01ab4df6098161efcc6cb1e70eaf1309cdd55f0be120a1a94a3c894049","3abd4a6da0d2a14af8c610e7f571e97f094c70ec62df1ca457b2a25942e5deea","3eeccaa32873fba5abf29f056ad63da1f9d943312a3b56d32475a88a3fd32fec","42e6c45ce744e5910f55492930eb15dfe085595e6a0970bda591f17a10ee762f","52ef85b520b5101f56ab4260afd9512e53eb82d518b4ca00edf3e88db2a75a8d","5a0057eeb1eda33a9d985e393c2585e9a172684fd07ce0966dff941a80ea0170","5cad3c1bc7c48e4d451e544eb3986c852da161285bad53de843aaf59619b79a3","5eddf05fb10af1b42b9d5fa2d107b9af12c94a97159b612d9ee49be3e2ed6661","69edea36d959004d8cba7d76ce317f4fffb167d7de3d1f0b0bbf45d5636ba83e","6c38bacb88654f6060fd18c6ccc78b1fafe4f707c460bc028843d056b9ea9ea9","6d2d0da8c219b71065b82ac6421712bfadbe3464daa8f19f1b7045023140a535","779e0059e0d225de85fd4a10c70cd078c7fbc060ea01178805e0d5354809ad30","858b52ec0601f03a4b03d2adfb83be4730fd88bf5f56a7d69baae8355c52eecb","96bee5ae0820232d7b100efaa26c94416c8e4db95c8de0ebdac735437b0d29a8","97824ad78b88b85b451c11474940f00fb7854e87043d36eb455b83987f709f73","a492b7a8a8e1ea575b5d2410451345e5c421f17c0030851c4f96411e24f05c53","a6007d41e8b4fb408d14fdc8b2ef57df9c70bc7b638b80ed3ef6d93811b1c6ae","b7ad4411c2b7126c6e4362df0daa8edf4e8ada71fe7384b574ef035b17c783d4","ef456bb42897192c5ced903fc9f88d796dc647aae0b1427c3e0718b4708142fe","f40255465851298c3f8b8d6afa8b4e7c207ba593e458bcfe61f86314d9eab336"],"recordQualifiers":{},"scopeLabel":"ORPHA:296","sourceIds":["ORPHA:296"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."}],"comparison":{"collapseColumnsLabel":"Show initial comparisons","defaultColumnKeys":["MONDO:0008145/OMIM:166000","MONDO:0008145/ORPHA:296"],"expandColumnsLabel":"Compare all source entries","intro":"Compare the original source entries. Different entries may describe different patient groups.","primaryFeatureIds":[],"scopeNoteHtml":"<p>Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.</p>"},"coverage":{"countRecords":0,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":30,"sourceGroups":{"omim":4,"orphanet":26,"published":0}},"features":[{"hpoId":"HP:0002763","label":"Abnormal cartilage morphology","primary":false},{"hpoId":"HP:0011314","label":"Abnormal long bone morphology","primary":false},{"hpoId":"HP:0000944","label":"Abnormal metaphysis morphology","primary":false},{"hpoId":"HP:0002653","label":"Bone pain","primary":false},{"hpoId":"HP:0006765","label":"Chondrosarcoma","primary":false},{"hpoId":"HP:0006824","label":"Cranial nerve paralysis","primary":false},{"hpoId":"HP:0002967","label":"Cubitus valgus","primary":false},{"hpoId":"HP:0000324","label":"Facial asymmetry","primary":false},{"hpoId":"HP:0002857","label":"Genu valgum","primary":false},{"hpoId":"HP:0002970","label":"Genu varum","primary":false},{"hpoId":"HP:0001028","label":"Hemangioma","primary":false},{"hpoId":"HP:0001387","label":"Joint stiffness","primary":false},{"hpoId":"HP:0100559","label":"Lower limb asymmetry","primary":false},{"hpoId":"HP:0100764","label":"Lymphangioma","primary":false},{"hpoId":"HP:0003067","label":"Madelung deformity","primary":false},{"hpoId":"HP:0002983","label":"Micromelia","primary":false},{"hpoId":"HP:0005701","label":"Multiple enchondromatosis","primary":false},{"hpoId":"HP:0002664","label":"Neoplasm","primary":false},{"hpoId":"HP:0002797","label":"Osteolysis","primary":false},{"hpoId":"HP:0002756","label":"Pathologic fracture","primary":false},{"hpoId":"HP:0100242","label":"Sarcoma","primary":false},{"hpoId":"HP:0002650","label":"Scoliosis","primary":false},{"hpoId":"HP:0200042","label":"Skin ulcer","primary":false},{"hpoId":"HP:0001482","label":"Subcutaneous nodule","primary":false},{"hpoId":"HP:0100560","label":"Upper limb asymmetry","primary":false},{"hpoId":"HP:0004936","label":"Venous thrombosis","primary":false},{"hpoId":"HP:0100761","label":"Visceral angiomatosis","primary":false}],"ledeHtml":"Ollier disease is a disorder characterized by multiple enchondromas, which are noncancerous (benign) growths of cartilage that develop within the bones. These growths most commonly occur in the limb bones, especially in the bones of the hands and feet; however, they may also occur in the skull, ribs, and bones of the spine (vertebrae). Enchondromas may result in severe bone deformities, shortening of the limbs, and fractures.","mondoId":"MONDO:0008145","records":[{"frequencyKind":"range","key":"09e7ddf9d48b2f8b49e90f408ff12b7ccc42bcc75b9b87b626bd836ea94a0e8c","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0100560","is_excluded":false,"label":"Upper limb asymmetry","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"18a350b477676b1ee42e5440962665574a6f32d22a52dc1e4644ce9f4dc71c48","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0000944","is_excluded":false,"label":"Abnormal metaphysis morphology","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"1f3e89f092dbdc07e056c82cb64dfb5297806b34d2918a0d8c197a8ac24303a0","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002857","is_excluded":false,"label":"Genu valgum","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"1ff5b55a22dcca33664b4afe55a53acdc2553e2aaffd82174d1ef20383b0d4e9","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0100761","is_excluded":false,"label":"Visceral angiomatosis","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"216631917ee2e549225cf75e1f52ba2ddf6a1f3caf45e7ec6d4201bd2341c596","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002664","is_excluded":false,"label":"Neoplasm","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"2e8abc8658ff5ce3dd6a7eff0677fcd6c45c8b4075c57b3847a01335e008279a","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002797","is_excluded":false,"label":"Osteolysis","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"2ef56b01ab4df6098161efcc6cb1e70eaf1309cdd55f0be120a1a94a3c894049","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0100559","is_excluded":false,"label":"Lower limb asymmetry","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"3abd4a6da0d2a14af8c610e7f571e97f094c70ec62df1ca457b2a25942e5deea","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002756","is_excluded":false,"label":"Pathologic fracture","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"3eeccaa32873fba5abf29f056ad63da1f9d943312a3b56d32475a88a3fd32fec","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002650","is_excluded":false,"label":"Scoliosis","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"42e6c45ce744e5910f55492930eb15dfe085595e6a0970bda591f17a10ee762f","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001387","is_excluded":false,"label":"Joint stiffness","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"52ef85b520b5101f56ab4260afd9512e53eb82d518b4ca00edf3e88db2a75a8d","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002967","is_excluded":false,"label":"Cubitus valgus","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5a0057eeb1eda33a9d985e393c2585e9a172684fd07ce0966dff941a80ea0170","raw":{"aspect":"P","body_system":"skin","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001482","is_excluded":false,"label":"Subcutaneous nodule","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5cad3c1bc7c48e4d451e544eb3986c852da161285bad53de843aaf59619b79a3","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002983","is_excluded":false,"label":"Micromelia","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5eddf05fb10af1b42b9d5fa2d107b9af12c94a97159b612d9ee49be3e2ed6661","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0002653","is_excluded":false,"label":"Bone pain","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"69edea36d959004d8cba7d76ce317f4fffb167d7de3d1f0b0bbf45d5636ba83e","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0100242","is_excluded":false,"label":"Sarcoma","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"6c38bacb88654f6060fd18c6ccc78b1fafe4f707c460bc028843d056b9ea9ea9","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000324","is_excluded":false,"label":"Facial asymmetry","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"6d2d0da8c219b71065b82ac6421712bfadbe3464daa8f19f1b7045023140a535","raw":{"aspect":"P","body_system":"skin","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0200042","is_excluded":false,"label":"Skin ulcer","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"75e1e78c7d90a2e75f3bc0abe9c02944dd6693023097c263368f353993f6f480","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:166000","disease_name":"Enchondromatosis, multiple","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0005701","is_excluded":false,"label":"Multiple enchondromatosis","onset_id":null,"reference":"OMIM:166000","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"779e0059e0d225de85fd4a10c70cd078c7fbc060ea01178805e0d5354809ad30","raw":{"aspect":"P","body_system":"immune","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0100764","is_excluded":false,"label":"Lymphangioma","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"858b52ec0601f03a4b03d2adfb83be4730fd88bf5f56a7d69baae8355c52eecb","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0001028","is_excluded":false,"label":"Hemangioma","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"96bee5ae0820232d7b100efaa26c94416c8e4db95c8de0ebdac735437b0d29a8","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002763","is_excluded":false,"label":"Abnormal cartilage morphology","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"97824ad78b88b85b451c11474940f00fb7854e87043d36eb455b83987f709f73","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0006824","is_excluded":false,"label":"Cranial nerve paralysis","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"9e7d861f75f72fda29fe84cc055d07d3442c7ce5b570d5f1cbe3b03ee1ac0bcb","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:166000","disease_name":"Enchondromatosis, multiple","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0006765","is_excluded":false,"label":"Chondrosarcoma","onset_id":null,"reference":"OMIM:166000","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"a492b7a8a8e1ea575b5d2410451345e5c421f17c0030851c4f96411e24f05c53","raw":{"aspect":"P","body_system":"blood","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0004936","is_excluded":false,"label":"Venous thrombosis","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"a6007d41e8b4fb408d14fdc8b2ef57df9c70bc7b638b80ed3ef6d93811b1c6ae","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0005701","is_excluded":false,"label":"Multiple enchondromatosis","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"b7ad4411c2b7126c6e4362df0daa8edf4e8ada71fe7384b574ef035b17c783d4","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0003067","is_excluded":false,"label":"Madelung deformity","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"bda4ea27e8a7cfbe58d5faca99d1c2f11fcfc6caa7feb22fa7522ef6feb3dda5","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:166000","disease_name":"Enchondromatosis, multiple","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0001028","is_excluded":false,"label":"Hemangioma","onset_id":null,"reference":"OMIM:166000","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"c6a63cc17d7a4cc3e321bccc2f3fa4bc0f87296be9c81e07466dd49c37ee3c79","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:166000","disease_name":"Enchondromatosis, multiple","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0011314","is_excluded":false,"label":"Abnormal long bone morphology","onset_id":null,"reference":"OMIM:166000","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"ef456bb42897192c5ced903fc9f88d796dc647aae0b1427c3e0718b4708142fe","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002970","is_excluded":false,"label":"Genu varum","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"f40255465851298c3f8b8d6afa8b4e7c207ba593e458bcfe61f86314d9eab336","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"ORPHA:296","disease_name":"Ollier disease","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0006765","is_excluded":false,"label":"Chondrosarcoma","onset_id":null,"reference":"ORPHA:296","source_release":"2026-06-23"},"sourceGroups":["orphanet"]}],"referenceLabels":{},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/ollier-disease\">Ollier disease</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>In most people with Ollier disease, the disorder is caused by mutations in the IDH1 or IDH2 gene. These genes provide instructions for making enzymes called isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2, respectively. These enzymes convert a compound called isocitrate to another compound called 2-ketoglutarate. This reaction also produces a molecule called NADPH, which is necessary for many cellular processes. IDH1 or IDH2 gene mutations cause the enzyme produced from the respective gene to take on a new, abnormal function. Although these mutations have been found in some cells of enchondromas in people with Ollier disease, the relationship between the mutations and the signs and symptoms of the disorder is not well understood.</p><p>Mutations in other genes may also account for some cases of Ollier disease.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/ollier-disease/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Ollier disease?"},{"bodyHtml":"<p>The signs and symptoms of Ollier disease may be detectable at birth, although they generally do not become apparent until around the age of 5. Enchondromas develop near the ends of bones, where normal growth occurs, and they frequently stop forming after affected individuals stop growing in early adulthood. As a result of the bone deformities associated with Ollier disease, people with this disorder generally have short stature and underdeveloped muscles.</p><p>Although the enchondromas associated with Ollier disease start out as benign, they may become cancerous (malignant). In particular, affected individuals may develop bone cancers called chondrosarcomas, especially in the skull. People with Ollier disease also have an increased risk of other cancers, such as ovarian cancer or liver cancer.</p><p>People with Ollier disease usually have a normal lifespan, and intelligence is unaffected. The extent of their physical impairment depends on their individual skeletal deformities, but in most cases they have no major limitations in their activities.</p><p>A related disorder called Maffucci syndrome also involves multiple enchondromas but is distinguished by the presence of red or purplish growths in the skin consisting of tangles of abnormal blood vessels (hemangiomas).</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/ollier-disease\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"ollier-disease","sourceDocuments":[{"name":"Ollier disease","reviewed":"2016-02","sections":{"causes":{"fetchedAt":"2026-10-20T20:23:55.236896+00:00","label":"Causes","pageSha256":"592f8400e70eb9c292f53a2a24ff10a5c240cc77ba346f6777bd48e764833af7","sourceUrl":"https://medlineplus.gov/genetics/condition/ollier-disease/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/ollier-disease"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Ollier disease"},"schemaVersion":1}