{"frequencyBands":{"HP:0040280":[100,100],"HP:0040281":[80,99],"HP:0040282":[30,79],"HP:0040283":[5,29],"HP:0040284":[1,4],"HP:0040285":[0,0]},"page":{"columns":[{"gene":"","key":"MONDO:0010239/OMIM:300067","label":"Lissencephaly, X-linked, 1","mondoId":"MONDO:0010239","onsetQualifier":null,"recordKeys":["00a2e168cc27eb6958e3cdc656b6ad8746bcf5e03a33b9a80c5ab2a7e3d270a5","071e9c6d244ed5666b964f1229c1e002606a448d15e514400c24244b9e794f31","26aa7edf7558de73ff44777c3f92038ff72345d26fae0d793e2ced472752739c","494db51f5a8e4796e35e05c8c3f7213ace242f892094872282441d0e8b6aa05a","4a32664efae03b29bfc599c925d74262443770e88a433ace7d0270e04f34c283","4f8a5dca60c782032c43dd70fe742d5e930a7961fcdb183d78b53dbb2519dd83","53d70a1d34e44c66876a2c43edf06bd50d9df85e2f65fd9e2b4bdd3e6f9028bb","54495f2f2dde538b827af61b4ff282ff3d446bf7144f82346309d6b829a97c44","6944fcac1b9d072d9479b91d446424f4136d6542a1741785c56c770d366e4582","75002dd16e5c773b4d8c75115b11daae7888fe4e000c75ad5a26c201ebe49eb4","8b1841a7545786c4fda710aa1c5ec59879ab244f921152ac912c787ce704ae69","9c37fe5a8283c2dac0c26e3661dbfd0f9b141fabf7f782a8db7b83a28fe3b410","af164c1d93a78eb55cadebac3efb189077876f997aa037c62d608baf7e6a81c7","e07c98ffd3034295f552e2b87f75a3f9230e788e6340f05727701e90fcde0f33","e44585ea540a4f2231671234b299119b80ef56dc1ead8d0abc4de95e1b84127c"],"recordQualifiers":{},"scopeLabel":"OMIM:300067","sourceIds":["OMIM:300067"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0010873/OMIM:600348","label":"Band heterotopia","mondoId":"MONDO:0010873","onsetQualifier":null,"recordKeys":["2eb1174eadafee02ceca3f80adfe85164b2564a1c43a766d5a91c6d53645adcf","358c5325e1dd7552da6527abffa39c1f2d8595857facbbdf10be04ca50ede73a","38875747e196642d3baabcf8308bd91534b7033cb10f54b4a577641bc51b9727","38aedbe816c28f6a14517fe995ce6bdb0f7514b4fc100d2dd7b4a00422c8fe5b","41bfbc8102bc5f989ba05e71a524ee1958631f9ed57bdd22aedb051ba4a8d1a5","74a6d6b559dadb8b0ec8beb6eacee09fbad2827756736c610adabee6e2e81640","78d24c6253dcc94654c42dfe8d557ccce9a5bc068805d706299af66b36315817","948cbf9d0d46e648ad3beb3730974bb0bea5f98a54c011df0b98f82cf201c7e6","950d1649cb041937eb91df38784bdf363436ae390d0e3650d97f8bbce7a447a4","a2e0375ee119b0423e2822998117b624477f3b8d2890dcadd761ed2097e3b25b","b7ce4e75b532f90d29f01f7fcf27c6e4729acd0096154297a14dc297b3e6c401","c986149a13f5628b2a1b479e18fb31738ddd0ff6d08bd54a28e9104ae257e36c","d5c2707b677055f92d158f588c2ab6f0ace1ce94af1df47ee8b966059289c512","d8991fbf6851eccc5cc3dafb180ab5fb99e06f0ca55035cb9842d08dee22d791","e18b4afcbf439ed3062c1201295c7a94b05d4531c7363e10a94d8762d3e9c92c","e95fbf70ff8e98f40da7015cb9742ead6f953c654da116a0bf4c90856816a09c","ee6be41474306601e4964ed7ec94b0c5ed5e8becb170c75ba132e1fcaba55323"],"recordQualifiers":{},"scopeLabel":"OMIM:600348","sourceIds":["OMIM:600348"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0010239/ORPHA:2148","label":"Lissencephaly type 1 due to doublecortin gene mutation","mondoId":"MONDO:0010239","onsetQualifier":null,"recordKeys":["0392dcf2a3fa748f3f40b1ba204f10780406799f1339f44b811daaca5f9cdd49","05bbcfbe602be234cdebeebebd5c982a16310a1d8199f988fd45fdf7de9c38c0","1025afb71f4df3bf7aa5abcb2ea9a60708877ecf14177e3233b3b7acb2cc5e3b","1e4006922982b1cac9135f2fbfc9c54fdfa7c555926013521b2f708c1ac03685","2970807ef62bf87ac4f633acc8acf911912c002cf3511710606085176d7dc6b7","2e0ad300a7bd11d8a93063f4078efbfde064dcd09ca91d86ccf5cf123eac7485","3f78f5153bdcf2fee8b1f2c4714a9bd6137f6e6008bfaeb41031837e5ef67a67","41b0227774681b7292861b831f3462897306dc3de2820f22463ca65fb40d6c98","433a1feab62d0fecf88727822b917bf11391879d68d11eede81384433b3e8f08","4ef188acb7ae2a7e06210e5ba4d9c308f464c72a9a51f5a7ef46b2c926aff563","50741621bdf349e5ac9cdf5412fc5c7f64f9d6476f52682dd3bc5f245489f347","520935d0ea5f5e0c2eccac50cf4b55978498f2baeaec3885c8e18dcdeadc2a43","5e433b7d16758d694fad6662dd737a9ecb62c11c7ab90940ee9aedc02ab10f5a","6604e50d2e0f77bfd510176293f7c7cd4dc4c03976ead089e49d18fa02ea85f9","7b5cc120d74490afeaa677cacf5fe86c6f6bd7c569cd42202567ee73098098a8","7fa58e5374f5cf7248616039bffdc2f8afa30cb25bc947f8ac4bf6e460766fd5","838c9d94e5fddb49853bd80cd1bd226228d266fd77457fe6da6aab625a4dce33","880d6d9324165e978653fb7b745fb72bd33dcebf01c9302cafea02534ac04b5c","909495701d0efc946c75273498824ce01163cd63d2941fd2f3b8202928046b93","a56308a96aa44999471c069a5182d71e6ebfbce81a14128d42d997e7364d474c","aab29ac8cbab09210a34b2d3b8710a0d54870d1fc1bd12360e5836dc6d675328","bf56e72ed5b86793f2bc9a43ecc5da8dd43744b091b78ec49ed869a3b925d132","cfe3f65b022a03be7464bb1ff6a56ea228d3df2529185870bf2cbc2841c04bc8","d15b63f7034001403df4325947fe509a0703a9757fd7f68730025de6c296c341","d651baefafac50e616f0aec2fc3bb5ec5d42b512d60d59e1619ae2b45777e566","ecb45fbf49b757dcebc6df25ee06306ddd7a3fbd7396c993d4a43c904d7d2e55","ecbe33e10d601563e5e78c34934baf5bace1a0e6b5a5162f150f59eb6b19bf9a","f43f7145379e808ca4660286651544fd87f918a89e9a130af0e101214e4bd838","f6d6dabd536292c3c5183d740107d68b1a8f1be15c934971815a7285410b465b","f6f13711440e05f41cc179775b1bd1cc884ba2f951406025af3a4c69e5874fca"],"recordQualifiers":{},"scopeLabel":"ORPHA:2148","sourceIds":["ORPHA:2148"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."}],"comparison":{"collapseColumnsLabel":"Show initial comparisons","defaultColumnKeys":["MONDO:0010239/OMIM:300067","MONDO:0010873/OMIM:600348","MONDO:0010239/ORPHA:2148"],"expandColumnsLabel":"Compare all source entries","intro":"Compare the original source entries. Different entries may describe different patient groups.","primaryFeatureIds":[],"scopeNoteHtml":"<p>Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.</p>"},"coverage":{"countRecords":14,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":62,"sourceGroups":{"omim":18,"orphanet":30,"published":14}},"features":[{"hpoId":"HP:0002339","label":"Abnormal caudate nucleus morphology","primary":false},{"hpoId":"HP:0003808","label":"Abnormal muscle tone","primary":false},{"hpoId":"HP:0001274","label":"Agenesis of corpus callosum","primary":false},{"hpoId":"HP:0000713","label":"Agitation","primary":false},{"hpoId":"HP:0031882","label":"Agyria","primary":false},{"hpoId":"HP:0012672","label":"Akinetic mutism","primary":false},{"hpoId":"HP:0002835","label":"Aspiration","primary":false},{"hpoId":"HP:0001251","label":"Ataxia (coordination difficulty)","primary":false},{"hpoId":"HP:0000708","label":"Atypical behavior","primary":false},{"hpoId":"HP:0000729","label":"Autistic behavior","primary":false},{"hpoId":"HP:0008936","label":"Axial hypotonia","primary":false},{"hpoId":"HP:0100021","label":"Cerebral palsy","primary":false},{"hpoId":"HP:0012762","label":"Cerebral white matter atrophy","primary":false},{"hpoId":"HP:0100543","label":"Cognitive impairment","primary":false},{"hpoId":"HP:0012448","label":"Delayed myelination","primary":false},{"hpoId":"HP:0012520","label":"Dilation of Virchow-Robin spaces","primary":false},{"hpoId":"HP:0001260","label":"Dysarthria","primary":false},{"hpoId":"HP:0002015","label":"Dysphagia","primary":false},{"hpoId":"HP:0200134","label":"Epileptic encephalopathy","primary":false},{"hpoId":"HP:0008872","label":"Feeding difficulties in infancy","primary":false},{"hpoId":"HP:0001371","label":"Flexion contracture","primary":false},{"hpoId":"HP:0007359","label":"Focal-onset seizure","primary":false},{"hpoId":"HP:0002197","label":"Generalized-onset seizure","primary":false},{"hpoId":"HP:0001263","label":"Global developmental delay","primary":false},{"hpoId":"HP:0002282","label":"Gray matter heterotopia","primary":false},{"hpoId":"HP:0000238","label":"Hydrocephalus","primary":false},{"hpoId":"HP:0002079","label":"Hypoplasia of the corpus callosum","primary":false},{"hpoId":"HP:0025517","label":"Hypoplastic hippocampus","primary":false},{"hpoId":"HP:0002521","label":"Hypsarrhythmia","primary":false},{"hpoId":"HP:0012469","label":"Infantile spasms","primary":false},{"hpoId":"HP:0001249","label":"Intellectual disability","primary":false},{"hpoId":"HP:0000737","label":"Irritability","primary":false},{"hpoId":"HP:0002463","label":"Language impairment","primary":false},{"hpoId":"HP:0006956","label":"Lateral ventricle dilatation","primary":false},{"hpoId":"HP:0001339","label":"Lissencephaly","primary":false},{"hpoId":"HP:0000256","label":"Macrocephaly","primary":false},{"hpoId":"HP:0000054","label":"Micropenis","primary":false},{"hpoId":"HP:0001270","label":"Motor delay","primary":false},{"hpoId":"HP:0000639","label":"Nystagmus","primary":false},{"hpoId":"HP:0001302","label":"Pachygyria","primary":false},{"hpoId":"HP:0001357","label":"Plagiocephaly","primary":false},{"hpoId":"HP:0002126","label":"Polymicrogyria","primary":false},{"hpoId":"HP:0007015","label":"Poor gross motor coordination","primary":false},{"hpoId":"HP:0008897","label":"Postnatal growth retardation","primary":false},{"hpoId":"HP:0012736","label":"Profound global developmental delay","primary":false},{"hpoId":"HP:0002650","label":"Scoliosis","primary":false},{"hpoId":"HP:0005484","label":"Secondary microcephaly","primary":false},{"hpoId":"HP:0001250","label":"Seizures","primary":false},{"hpoId":"HP:0010864","label":"Severe intellectual disability","primary":false},{"hpoId":"HP:0002360","label":"Sleep disturbance","primary":false},{"hpoId":"HP:0001257","label":"Spasticity","primary":false},{"hpoId":"HP:0032409","label":"Subcortical band heterotopia","primary":false},{"hpoId":"HP:0002119","label":"Ventriculomegaly","primary":false}],"ledeHtml":"Subcortical band heterotopia is a condition in which nerve cells (neurons) do not move (migrate) to their proper locations in the fetal brain during early development. (Heterotopia means &quot;out of place.&quot;) Normally, the neurons that make up the outer surface of the brain (cerebral cortex) are distributed in a well-organized and multi-layered way. In people with subcortical band heterotopia, some neurons that should be part of the cerebral cortex do not reach it. These neurons stop their migration process in areas of the brain where they are not supposed to be and form band-like clusters of tissue. Since these bands are located beneath the cerebral cortex, they are said to be subcortical. In most cases, the bands are symmetric, which means they occur in the same places on the right and left sides of the brain.","mondoId":"MONDO:0020491","records":[{"frequencyKind":"reported","key":"00a2e168cc27eb6958e3cdc656b6ad8746bcf5e03a33b9a80c5ab2a7e3d270a5","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0008936","is_excluded":false,"label":"Axial hypotonia","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"0392dcf2a3fa748f3f40b1ba204f10780406799f1339f44b811daaca5f9cdd49","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0100543","is_excluded":false,"label":"Cognitive impairment","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"05bbcfbe602be234cdebeebebd5c982a16310a1d8199f988fd45fdf7de9c38c0","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002079","is_excluded":false,"label":"Hypoplasia of the corpus callosum","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"071e9c6d244ed5666b964f1229c1e002606a448d15e514400c24244b9e794f31","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001250","is_excluded":false,"label":"Seizure","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"1025afb71f4df3bf7aa5abcb2ea9a60708877ecf14177e3233b3b7acb2cc5e3b","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0006956","is_excluded":false,"label":"Lateral ventricle dilatation","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"1e4006922982b1cac9135f2fbfc9c54fdfa7c555926013521b2f708c1ac03685","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0001250","is_excluded":false,"label":"Seizure","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"26aa7edf7558de73ff44777c3f92038ff72345d26fae0d793e2ced472752739c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001251","is_excluded":false,"label":"Ataxia","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"2970807ef62bf87ac4f633acc8acf911912c002cf3511710606085176d7dc6b7","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0007359","is_excluded":false,"label":"Focal-onset seizure","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"2e0ad300a7bd11d8a93063f4078efbfde064dcd09ca91d86ccf5cf123eac7485","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002339","is_excluded":false,"label":"Abnormal caudate nucleus morphology","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"2eb1174eadafee02ceca3f80adfe85164b2564a1c43a766d5a91c6d53645adcf","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"4/4","hpo_id":"HP:0032409","is_excluded":false,"label":"Subcortical band heterotopia","onset_id":null,"reference":"PMID:28556411;PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"358c5325e1dd7552da6527abffa39c1f2d8595857facbbdf10be04ca50ede73a","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0012736","is_excluded":false,"label":"Profound global developmental delay","onset_id":null,"reference":"PMID:28556411","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"38875747e196642d3baabcf8308bd91534b7033cb10f54b4a577641bc51b9727","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"4/4","hpo_id":"HP:0001274","is_excluded":false,"label":"Agenesis of corpus callosum","onset_id":null,"reference":"PMID:28556411;PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"38aedbe816c28f6a14517fe995ce6bdb0f7514b4fc100d2dd7b4a00422c8fe5b","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/3","hpo_id":"HP:0025517","is_excluded":false,"label":"Hypoplastic hippocampus","onset_id":null,"reference":"PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"3f78f5153bdcf2fee8b1f2c4714a9bd6137f6e6008bfaeb41031837e5ef67a67","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000729","is_excluded":false,"label":"Autistic behavior","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"41b0227774681b7292861b831f3462897306dc3de2820f22463ca65fb40d6c98","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002521","is_excluded":false,"label":"Hypsarrhythmia","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"41bfbc8102bc5f989ba05e71a524ee1958631f9ed57bdd22aedb051ba4a8d1a5","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"3/3","hpo_id":"HP:0010864","is_excluded":false,"label":"Severe intellectual disability","onset_id":null,"reference":"PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"433a1feab62d0fecf88727822b917bf11391879d68d11eede81384433b3e8f08","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0003808","is_excluded":false,"label":"Abnormal muscle tone","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"494db51f5a8e4796e35e05c8c3f7213ace242f892094872282441d0e8b6aa05a","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001302","is_excluded":false,"label":"Pachygyria","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"4a32664efae03b29bfc599c925d74262443770e88a433ace7d0270e04f34c283","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001270","is_excluded":false,"label":"Motor delay","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"4ef188acb7ae2a7e06210e5ba4d9c308f464c72a9a51f5a7ef46b2c926aff563","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001302","is_excluded":false,"label":"Pachygyria","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"4f8a5dca60c782032c43dd70fe742d5e930a7961fcdb183d78b53dbb2519dd83","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001257","is_excluded":false,"label":"Spasticity","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"50741621bdf349e5ac9cdf5412fc5c7f64f9d6476f52682dd3bc5f245489f347","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0100021","is_excluded":false,"label":"Cerebral palsy","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"520935d0ea5f5e0c2eccac50cf4b55978498f2baeaec3885c8e18dcdeadc2a43","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0007015","is_excluded":false,"label":"Poor gross motor coordination","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"53d70a1d34e44c66876a2c43edf06bd50d9df85e2f65fd9e2b4bdd3e6f9028bb","raw":{"aspect":"P","body_system":"growth","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0008897","is_excluded":false,"label":"Postnatal growth retardation","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"54495f2f2dde538b827af61b4ff282ff3d446bf7144f82346309d6b829a97c44","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001339","is_excluded":false,"label":"Lissencephaly","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"5e433b7d16758d694fad6662dd737a9ecb62c11c7ab90940ee9aedc02ab10f5a","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0031882","is_excluded":false,"label":"Agyria","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"6604e50d2e0f77bfd510176293f7c7cd4dc4c03976ead089e49d18fa02ea85f9","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0012762","is_excluded":false,"label":"Cerebral white matter atrophy","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"6944fcac1b9d072d9479b91d446424f4136d6542a1741785c56c770d366e4582","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000054","is_excluded":false,"label":"Micropenis","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"74a6d6b559dadb8b0ec8beb6eacee09fbad2827756736c610adabee6e2e81640","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0000708","is_excluded":false,"label":"Atypical behavior","onset_id":null,"reference":"OMIM:600348","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"75002dd16e5c773b4d8c75115b11daae7888fe4e000c75ad5a26c201ebe49eb4","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001274","is_excluded":false,"label":"Agenesis of corpus callosum","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"78d24c6253dcc94654c42dfe8d557ccce9a5bc068805d706299af66b36315817","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"3/3","hpo_id":"HP:0001263","is_excluded":false,"label":"Global developmental delay","onset_id":null,"reference":"PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"7b5cc120d74490afeaa677cacf5fe86c6f6bd7c569cd42202567ee73098098a8","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0002463","is_excluded":false,"label":"Language impairment","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"7fa58e5374f5cf7248616039bffdc2f8afa30cb25bc947f8ac4bf6e460766fd5","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001371","is_excluded":false,"label":"Flexion contracture","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"838c9d94e5fddb49853bd80cd1bd226228d266fd77457fe6da6aab625a4dce33","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0005484","is_excluded":false,"label":"Secondary microcephaly","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"880d6d9324165e978653fb7b745fb72bd33dcebf01c9302cafea02534ac04b5c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0200134","is_excluded":false,"label":"Epileptic encephalopathy","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"8b1841a7545786c4fda710aa1c5ec59879ab244f921152ac912c787ce704ae69","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0000639","is_excluded":false,"label":"Nystagmus","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"909495701d0efc946c75273498824ce01163cd63d2941fd2f3b8202928046b93","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0012672","is_excluded":false,"label":"Akinetic mutism","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"948cbf9d0d46e648ad3beb3730974bb0bea5f98a54c011df0b98f82cf201c7e6","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/3","hpo_id":"HP:0001357","is_excluded":false,"label":"Plagiocephaly","onset_id":null,"reference":"PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"950d1649cb041937eb91df38784bdf363436ae390d0e3650d97f8bbce7a447a4","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/3","hpo_id":"HP:0002119","is_excluded":false,"label":"Ventriculomegaly","onset_id":null,"reference":"PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"9c37fe5a8283c2dac0c26e3661dbfd0f9b141fabf7f782a8db7b83a28fe3b410","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"PCS","frequency_raw":null,"hpo_id":"HP:0001249","is_excluded":false,"label":"Intellectual disability","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"a2e0375ee119b0423e2822998117b624477f3b8d2890dcadd761ed2097e3b25b","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0002282","is_excluded":false,"label":"Gray matter heterotopia","onset_id":null,"reference":"PMID:28556411","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"a56308a96aa44999471c069a5182d71e6ebfbce81a14128d42d997e7364d474c","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0012520","is_excluded":false,"label":"Dilation of Virchow-Robin spaces","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"aab29ac8cbab09210a34b2d3b8710a0d54870d1fc1bd12360e5836dc6d675328","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002015","is_excluded":false,"label":"Dysphagia","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"af164c1d93a78eb55cadebac3efb189077876f997aa037c62d608baf7e6a81c7","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0031882","is_excluded":false,"label":"Agyria","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"b7ce4e75b532f90d29f01f7fcf27c6e4729acd0096154297a14dc297b3e6c401","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0002360","is_excluded":false,"label":"Sleep disturbance","onset_id":null,"reference":"OMIM:600348","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"bf56e72ed5b86793f2bc9a43ecc5da8dd43744b091b78ec49ed869a3b925d132","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000713","is_excluded":false,"label":"Agitation","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"c986149a13f5628b2a1b479e18fb31738ddd0ff6d08bd54a28e9104ae257e36c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0001257","is_excluded":false,"label":"Spasticity","onset_id":null,"reference":"OMIM:600348","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"cfe3f65b022a03be7464bb1ff6a56ea228d3df2529185870bf2cbc2841c04bc8","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0002197","is_excluded":false,"label":"Generalized-onset seizure","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"d15b63f7034001403df4325947fe509a0703a9757fd7f68730025de6c296c341","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000737","is_excluded":false,"label":"Irritability","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"d5c2707b677055f92d158f588c2ab6f0ace1ce94af1df47ee8b966059289c512","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"4/5","hpo_id":"HP:0001250","is_excluded":false,"label":"Seizure","onset_id":null,"reference":"PMID:28556411;PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"d651baefafac50e616f0aec2fc3bb5ec5d42b512d60d59e1619ae2b45777e566","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0000708","is_excluded":false,"label":"Atypical behavior","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"d8991fbf6851eccc5cc3dafb180ab5fb99e06f0ca55035cb9842d08dee22d791","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"4/4","hpo_id":"HP:0002126","is_excluded":false,"label":"Polymicrogyria","onset_id":null,"reference":"PMID:28556411;PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"e07c98ffd3034295f552e2b87f75a3f9230e788e6340f05727701e90fcde0f33","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0002282","is_excluded":false,"label":"Gray matter heterotopia","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"e18b4afcbf439ed3062c1201295c7a94b05d4531c7363e10a94d8762d3e9c92c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0000238","is_excluded":false,"label":"Hydrocephalus","onset_id":null,"reference":"PMID:28556411","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"reported","key":"e44585ea540a4f2231671234b299119b80ef56dc1ead8d0abc4de95e1b84127c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:300067","disease_name":"Lissencephaly, X-linked, 1","evidence":"IEA","frequency_raw":null,"hpo_id":"HP:0001260","is_excluded":false,"label":"Dysarthria","onset_id":null,"reference":"OMIM:300067","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"e95fbf70ff8e98f40da7015cb9742ead6f953c654da116a0bf4c90856816a09c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0006956","is_excluded":false,"label":"Lateral ventricle dilatation","onset_id":null,"reference":"PMID:28556411","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"ecb45fbf49b757dcebc6df25ee06306ddd7a3fbd7396c993d4a43c904d7d2e55","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0012448","is_excluded":false,"label":"Delayed myelination","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"ecbe33e10d601563e5e78c34934baf5bace1a0e6b5a5162f150f59eb6b19bf9a","raw":{"aspect":"P","body_system":"digestive","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0008872","is_excluded":false,"label":"Feeding difficulties in infancy","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"ee6be41474306601e4964ed7ec94b0c5ed5e8becb170c75ba132e1fcaba55323","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:600348","disease_name":"Band heterotopia","evidence":"PCS","frequency_raw":"3/3","hpo_id":"HP:0000256","is_excluded":false,"label":"Macrocephaly","onset_id":null,"reference":"PMID:24859200","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"f43f7145379e808ca4660286651544fd87f918a89e9a130af0e101214e4bd838","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002650","is_excluded":false,"label":"Scoliosis","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"f6d6dabd536292c3c5183d740107d68b1a8f1be15c934971815a7285410b465b","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0012469","is_excluded":false,"label":"Infantile spasms","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"f6f13711440e05f41cc179775b1bd1cc884ba2f951406025af3a4c69e5874fca","raw":{"aspect":"P","body_system":"respiratory","disease_id":"ORPHA:2148","disease_name":"Lissencephaly type 1 due to doublecortin gene mutation","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002835","is_excluded":false,"label":"Aspiration","onset_id":null,"reference":"ORPHA:2148","source_release":"2026-06-23"},"sourceGroups":["orphanet"]}],"referenceLabels":{},"references":{"causeHtml":"<ul><li><a href=\"https://medlineplus.gov/genetics/condition/subcortical-band-heterotopia\">Subcortical band heterotopia</a></li></ul>","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Mutations in the DCX or PAFAH1B1 gene cause subcortical band heterotopia. Both genes provide instructions for making proteins that are involved in the movement of neurons to their proper locations in the developing brain, a process called neuronal migration. Neuronal migration is essential for normal brain development and function.</p><p>Most individuals with subcortical band heterotopia have DCX gene mutations. These mutations impair the protein&#x27;s function or alter the protein&#x27;s structure or stability. PAFAH1B1 gene mutations are less common. Mutations in this gene reduce the protein&#x27;s function.</p><p>Altered structure or function of the proteins produced by the DCX or PAFAH1B1 gene impairs important interactions that are needed for neuronal migration. Without proper neuronal migration, neurons in the developing brain can be misplaced, forming abnormal bands of tissue beneath the cerebral cortex.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/subcortical-band-heterotopia/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Subcortical band heterotopia?"},{"bodyHtml":"<p>The abnormal brain development causes neurological problems in people with subcortical band heterotopia. The signs and symptoms of the condition depend on the size of the bands and the lack of development of the cerebral cortex. The signs and symptoms can vary from severe intellectual disability and seizures that begin early in life and affect both sides of the brain (generalized seizures) to normal intelligence with seizures occurring later in life and affecting only one side of the brain (focal seizures). Some affected individuals also have weak muscle tone (hypotonia), loss of fine motor skills such as using utensils, or behavioral problems. Subcortical band heterotopia is typically found when brain imaging is done following the onset of seizures, usually in adolescence or early adulthood.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/subcortical-band-heterotopia\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"subcortical-band-heterotopia","sourceDocuments":[{"name":"Subcortical band heterotopia","reviewed":"2018-08","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:19.656411+00:00","label":"Causes","pageSha256":"a0cb215f79c0e7de7e5fdd681d512615d2c97896e4c1a32a23c935fe422dcfd2","sourceUrl":"https://medlineplus.gov/genetics/condition/subcortical-band-heterotopia/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/subcortical-band-heterotopia"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Subcortical band heterotopia"},"schemaVersion":1}