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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Most cases of trisomy 13 result from having three copies of chromosome 13 in each cell in the body instead of the usual two copies. The extra genetic material disrupts the normal course of development, causing the characteristic features of trisomy 13.</p><p>Trisomy 13 can also occur when chromosome 13 becomes attached (translocated) to another chromosome during the formation of reproductive cells (eggs and sperm) or very early in fetal development. Affected people have two normal copies of chromosome 13, plus an extra copy of chromosome 13 attached to another chromosome. In rare cases, only part of chromosome 13 is present in three copies. The physical signs and symptoms in these cases may be different than those found in full trisomy 13.</p><p>A small percentage of people with trisomy 13 have an extra copy of chromosome 13 in only some of the body&#x27;s cells. In these people, the condition is called mosaic trisomy 13. The severity of mosaic trisomy 13 depends on the type and number of cells that have the extra chromosome. The physical features of mosaic trisomy 13 are often milder than those of full trisomy 13.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/trisomy-13/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Trisomy 13?"},{"bodyHtml":"<p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/trisomy-13\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"trisomy-13","sourceDocuments":[{"name":"Trisomy 13","reviewed":"2009-01","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:33.872052+00:00","label":"Causes","pageSha256":"a9a66445025d23ef59bd8431bab5a6d28f31708db663626e33970e31f2d75756","sourceUrl":"https://medlineplus.gov/genetics/condition/trisomy-13/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/trisomy-13"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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