Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.
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This condition is characterized by abnormal inflammation of the inner surface (epithelium) of the rectum and colon. The rectum and colon make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between the age of 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout a person's life, which causes recurring signs and symptoms.","mondoId":"MONDO:0009960","records":[{"frequencyKind":"reported","key":"0d9d370b194b32a2dd9a0e92052d67c3742a7e2a192b3814e658256c11b8ec04","raw":{"aspect":"P","body_system":"growth","disease_id":"OMIM:266600","disease_name":"Inflammatory bowel disease 1, Crohn disease","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0001824","is_excluded":false,"label":"Weight loss","onset_id":null,"reference":"OMIM:266600","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"reported","key":"21274cccd7a57c9ae4396ce1085a7eb245bb74761b5123cc7eb9584093dc5442","raw":{"aspect":"P","body_system":"digestive","disease_id":"OMIM:266600","disease_name":"Inflammatory bowel disease 1, Crohn disease","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0100819","is_excluded":false,"label":"Intestinal 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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"A variety of genetic and environmental factors are likely involved in the development of ulcerative colitis. Recent studies have identified variations in dozens of genes that may be linked to ulcerative colitis; however, the role of these variations is not completely understood. Researchers speculate that this condition may be caused by changes in the intestinal lining's protective function or an abnormal immune response to the normal bacteria in the digestive tract, both of which may be influenced by genetic variations.
Several of the genes that may be associated with ulcerative colitis are involved in the protective function of the intestines. The inner surface of the intestines provides a barrier that protects the body's tissues from the bacteria that live in the intestines and from toxins that pass through the digestive tract. Researchers speculate that a breakdown of this barrier allows contact between the intestinal tissue and the bacteria and toxins, which can trigger an immune reaction. This immune response may lead to chronic inflammation and the digestive problems characteristic of ulcerative colitis.
Genes that regulate the immune system may also contribute to ulcerative colitis, particularly genes that are involved in the maturation and function of immune cells called T cells. T cells identify foreign substances and defend the body against infection. Certain genetic variations may make some individuals more prone to an overactive immune response to the bacteria and other microbes in the intestines, which may cause the chronic inflammation that occurs in people with ulcerative colitis. Another possible explanation is that ulcerative colitis occurs when the immune system malfunctions and attacks the cells of the intestines, causing inflammation.
","key":"forms","title":"What causes Ulcerative colitis?"},{"bodyHtml":"The most common symptoms of ulcerative colitis are cramping abdominal pain and frequent diarrhea, often with blood, pus, or mucus in the stool. Other signs and symptoms include nausea, loss of appetite, bowel urgency, fatigue, and fevers. Chronic bleeding from the inflamed and ulcerated intestinal tissue can cause a shortage of red blood cells (anemia) in some affected individuals. People with this disorder have difficulty absorbing enough fluids and nutrients from their diet and often experience weight loss. Affected children usually grow more slowly than normal. Less commonly, ulcerative colitis causes problems with the skin, joints, eyes, kidneys, or liver, which are most likely due to abnormal inflammation.
Toxic megacolon is a rare complication of ulcerative colitis that can be life-threatening. Toxic megacolon involves a widening (dilation) of the colon and an overwhelming inflammatory response. Ulcerative colitis also increases the risk of developing colon cancer, especially in people whose entire colon is inflamed and in those who have had ulcerative colitis for 8 years or more.
Ulcerative colitis is one common form of inflammatory bowel disease (IBD). Another type of IBD, Crohn's disease, also causes chronic inflammation of the intestines. Unlike ulcerative colitis, which affects only the inner surface of the large intestine, Crohn's disease can cause inflammation in any part of the digestive system, and the inflammation extends deeper into the intestinal tissue.
Source: MedlinePlus Genetics
","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"ulcerative-colitis","sourceDocuments":[{"name":"Ulcerative colitis","reviewed":"2023-08","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:38.831295+00:00","label":"Causes","pageSha256":"86c1d408bbca92894a0c603d707d68c1da7887e1a26ac72e349354dac4e4b863","sourceUrl":"https://medlineplus.gov/genetics/condition/ulcerative-colitis/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/ulcerative-colitis"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Ulcerative colitis"},"schemaVersion":1}