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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Variations (also known as mutations) in the IRF6 gene cause most cases of van der Woude syndrome. The IRF6 gene provides instructions for making a protein that plays an important role in early development. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The IRF6 protein is active in cells that give rise to tissues in the head and face. It is also involved in the development of other parts of the body, including the skin and genitals.</p><p>Variants in the IRF6 gene that cause van der Woude syndrome prevent one copy of the gene in each cell from making any functional protein. A shortage of the IRF6 protein affects the development and maturation of tissues in the face, resulting in the signs and symptoms of van der Woude syndrome.</p><p>In about five percent of cases, van der Woude syndrome is caused by variants in the GRHL3 gene.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/van-der-woude-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Van der Woude syndrome?"},{"bodyHtml":"<p>People with van der Woude syndrome who have cleft lip and/or palate, like other individuals with these facial conditions, have an increased risk of delayed language development, learning disabilities, or other mild cognitive problems. The average IQ of individuals with van der Woude syndrome is not significantly different from that of the general population.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/van-der-woude-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"van-der-woude-syndrome","sourceDocuments":[{"name":"Van der Woude syndrome","reviewed":"2022-07","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:40.911628+00:00","label":"Causes","pageSha256":"13b57952dd882af9a741789d787a06ff6d4888c96c91a228de8f301e20945d1c","sourceUrl":"https://medlineplus.gov/genetics/condition/van-der-woude-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/van-der-woude-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Van der Woude syndrome"},"schemaVersion":1}