Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.
"},"coverage":{"countRecords":4,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":4,"sourceGroups":{"omim":0,"orphanet":0,"published":4}},"features":[{"hpoId":"HP:0011971","label":"Dermatographic urticaria","primary":false},{"hpoId":"HP:0001041","label":"Facial erythema","primary":false},{"hpoId":"HP:0031284","label":"Flushing","primary":false},{"hpoId":"HP:0001025","label":"Urticaria","primary":false}],"ledeHtml":"Vibratory urticaria is a condition in which exposing the skin to vibration, repetitive stretching, or friction results in allergy symptoms such as hives (urticaria), swelling (angioedema), redness (erythema), and itching (pruritus) in the affected area. The reaction can be brought on by towel drying, hand clapping, running, a bumpy ride in a vehicle, or other repetitive stimulation. Headaches, fatigue, faintness, blurry vision, a metallic taste in the mouth, facial flushing, and more widespread swelling (especially of the face) can also occur during these episodes, especially if the stimulation is extreme or prolonged. The reaction occurs within a few minutes of the stimulation and generally lasts up to an hour. Affected individuals can have several episodes per day.","mondoId":"MONDO:0007447","records":[{"frequencyKind":"count","key":"4c2482688b4392a59a5f2abe66db61776db79f55edff48f9c0942a273c015bf7","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:125630","disease_name":"Dermodistortive urticaria","evidence":"PCS","frequency_raw":"9/9","hpo_id":"HP:0001041","is_excluded":false,"label":"Facial erythema","onset_id":null,"reference":"PMID:26841242","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"748528b87f1db3537211ab0d7ea9b636b168cf727e4db18c22fbe125d50ed768","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:125630","disease_name":"Dermodistortive urticaria","evidence":"PCS","frequency_raw":"0/9","hpo_id":"HP:0011971","is_excluded":true,"label":"Dermatographic urticaria","onset_id":null,"reference":"PMID:26841242","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"aa0c40f3d5ffdf8b2b543827b1801dcb7a3909a213cb73526a373b5df443415c","raw":{"aspect":"P","body_system":"skin","disease_id":"OMIM:125630","disease_name":"Dermodistortive urticaria","evidence":"PCS","frequency_raw":"9/9","hpo_id":"HP:0031284","is_excluded":false,"label":"Flushing","onset_id":null,"reference":"PMID:26841242","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"ed1bfd2f22ebc455c642c707c0edc7e717414daf0bf26c92f620f199446a261f","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:125630","disease_name":"Dermodistortive urticaria","evidence":"PCS","frequency_raw":"9/9","hpo_id":"HP:0001025","is_excluded":false,"label":"Urticaria","onset_id":null,"reference":"PMID:26841242","source_release":"2026-06-23"},"sourceGroups":["published"]}],"referenceLabels":{},"references":{"causeHtml":"","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"Vibratory urticaria can be caused by a mutation in the ADGRE2 gene. This gene provides instructions for making a protein found in several types of immune system cells, including mast cells. Mast cells, which are found in many body tissues including the skin, are important for the normal protective functions of the immune system. They also play a role in allergic reactions, which occur when the immune system overreacts to stimuli that are not harmful. The specific role of the ADGRE2 protein in mast cells is not well understood.
The ADGRE2 protein consists of two parts (subunits) that interact with each other: an alpha subunit that lies on the outside surface of the cell and a beta subunit that crosses the cell membrane and extends into the cell. The ADGRE2 gene mutation that causes vibratory urticaria changes a single protein building block (amino acid) in the alpha subunit, altering the protein structure and leading to a less stable interaction between the two subunits. This fragile connection can be more easily broken; vibration, friction, or stretching of the skin can disrupt the association between subunits in mast cells. Researchers suggest that once the subunits are disconnected, the beta subunit signals the mast cells to react and produce the allergy symptoms in the skin that occur in vibratory urticaria.
Some people with vibratory urticaria do not have a mutation in the ADGRE2 gene. In these affected individuals, the cause of the disorder is unknown.
","key":"forms","title":"What causes Vibratory urticaria?"},{"bodyHtml":"Source: MedlinePlus Genetics
","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"vibratory-urticaria","sourceDocuments":[{"name":"Vibratory urticaria","reviewed":"2016-07","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:41.866546+00:00","label":"Causes","pageSha256":"2836a88300f75f48a2e7456d3943ea6935a9c5f7103e3bcc1e0d64866e54326d","sourceUrl":"https://medlineplus.gov/genetics/condition/vibratory-urticaria/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/vibratory-urticaria"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"Vibratory urticaria"},"schemaVersion":1}