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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Genetic changes that cause disease are called pathogenic variants. Pathogenic variants in the VCAN gene cause Wagner syndrome. The VCAN gene provides instructions for making a protein called versican core protein. This protein is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. Versican core protein interacts with many of these molecules to provide structure and support to the extracellular matrix. Within the eye, versican core portein helps maintain the gel-like consistency of the vitreous.</p><p>The pathogenic variants in the VCAN gene that are associated with Wagner syndrome cause cells to produce a version of the protein that does not function properly. As a result, there is not enough functioning versican core protein to keep the vitreous in its gel-like state. This lack of stability in the vitreous affects the retina and contributes to the vision problems that are characteristic of this disorder. Researchers are working to learn more about how pathogenic variants in the VCAN gene affect other tissues.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/wagner-syndrome/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes Wagner syndrome?"},{"bodyHtml":"<p>In people with Wagner syndrome, the light-sensitive tissue that lines the back of the eye (the retina) becomes thin and may separate from the back of the eye (retinal detachment). The blood vessels within the retina (known as the choroid) may also be abnormal. The retina and the choroid progressively break down (degenerate). Some people with Wagner syndrome have blurred vision because of ectopic fovea, an abnormality in which the part of the retina responsible for sharp central vision is out of place. Additionally, the thick, clear gel that fills the eyeball (the vitreous) becomes watery and thin. People with Wagner syndrome develop a clouding of the lens of the eye (cataract). Affected individuals may also experience nearsightedness (myopia), progressive night blindness, or a narrowing of their field of vision.</p><p>Vision impairment in people with Wagner syndrome can vary from near normal vision to complete loss of vision in both eyes.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/wagner-syndrome\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"wagner-syndrome","sourceDocuments":[{"name":"Wagner syndrome","reviewed":"2010-01","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:44.889179+00:00","label":"Causes","pageSha256":"d035a077e1a33591fa7a5a55a068cb878acff6e381f70e61f27829c293df8ca8","sourceUrl":"https://medlineplus.gov/genetics/condition/wagner-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/wagner-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. 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