{"frequencyBands":{"HP:0040280":[100,100],"HP:0040281":[80,99],"HP:0040282":[30,79],"HP:0040283":[5,29],"HP:0040284":[1,4],"HP:0040285":[0,0]},"page":{"columns":[{"gene":"","key":"MONDO:0008681/OMIM:194072","label":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","mondoId":"MONDO:0008681","onsetQualifier":null,"recordKeys":["17190ad8f532fbd0594717996bde2e95f903b873a07bfd58c1eec91ba259c358","24e935c592655701f475759daf5fbd2c90a9f52fd6340544f98d09df6c6d87e4","3db1387ebf8486ade7bdbf978211e9eac93b3986b425f65e90270987bb844058","51b43b6bab3a089bab8ec55c314c0ce357a6b407d45757f75c650c8cc3415950","7317e94abd3859ae519a2ddc89ac9810c78f1979d5a5373ba5d4c51eff624779","79f396ac1b4db35cc5fe1260fa9fd126336d467ba621916d48f2c816ed2cd314","8712a395136339c7705427dc9b60d244562b3d341f485fa18d1bfe8e80e58935","8a9ed7f4b0702c6396a26ce5c92604d4c61167671471953c9b6399b1b5aedf2c","a3961e7446df80a62fa069c8bb736d9744f5a49ccf8f3c8473b07967bef49552","a7c08b62cc7c90a3b44ff95a5a27d55849fc4a4e70bb4e7d07f8d1bcb8f4e627","acac7ce7ac02db95c8ece3d60562879ad451e83cf0477846f5ea3c88492b17a9","dee318657ab4ba128bf0ffdd033e90b2b5bfd3084eb2b1d116400a03d388e51b"],"recordQualifiers":{},"scopeLabel":"OMIM:194072","sourceIds":["OMIM:194072"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0012913/OMIM:612469","label":"WAGRO syndrome","mondoId":"MONDO:0012913","onsetQualifier":null,"recordKeys":["05b76d85d70499083b15722bfeb8b0b7633abaf88dfa70cf67f921d5db87a143","06800e9f4b2463431163ed1fec5fdd0e13de573ce40728aef22dfbda208b945c","0b8003648fe6b527363e76831648ec7036790dde4514a781041f070bde08bb3c","26eb2d9e43326ea1daad7c1060e147992168f5853c61872ecf6ac46dd6f0c096","2c38a28e4eb263c0fe839b57694c08e5d86265078814a61f774a801a5ff9c666","327875ccb0a9ccbd5da94a9ba3aa9632587a31baffab19e04908a8ce2031a8b5","3db3cc8e12082771b7446695ae0860ebbc8a488df856372b06fac0185dcb9753","59613f67f037a2d81514f724cc8c926cb3a8402d6d7daa346686d2a00f2cced6","5efae714c92c4ca8673c3b90d3bb93f1212b8569adc2738d0c3db7e6af91952f","67418e2ccf1980903adb33a09f9079820b17548e76f64e9de8856df07e4b5642","6a04ac5a4e209e008d72768b71a39c4cc527746c99e907201604800c5bf071b3","6ccb8cd34c548cd5dc5c52f8c823753e7f114a7647e1a7a99c405cc863d1dacc","7116ab20401a302c3b2eaea54587ddcf51edb1cdb215380cf8555e5938941ab6","7b64e7c97e1122f9ac05ef6ceb9178511eebcb461f04261c0d8732a7d2e468d7","7f0934e1a5a77c27f719fda50ba72af28d919dd43cae2308d8e5b0f99e0d7f14","84a5315250ad52271327366b198a60e4fe1a0411e449611ad1fa22298626dabe","9cab9786e9e06987787b49c1293a67a6c5f9978c08bf866d31514cff79b7fc75","9ebe1f51ecc2bd8a2d34a623772a899ec40117beee5110b564d229dd0fef86c7","a24fd9cc174e397ce93ee03a96d4ced57cb025f23f2107739cde02140e50f77b","abbca0f7af1079b0110b543cb2ff2f21de291df72b992164986a77e95d89f323","ae67525e2a70f804875d31a1785b98355dec925aa6f04e562897f0c6ff4bae07","bb1d9d6ed084796c8f1b2ce06910dc4d6f62b2bb8952d993052d710fb26a51ed","bde2c7d9cf1f7038847833c706943c802d775539981b20242203679578119fc2","c62668aa0737ca89da222357143f2489b7fee9eb6e242baebbcb05df23b4d094","d111d0a0a89f0864881c8ee66912330e5e63957e1062919ce4829191cd45c3da","d4e5ff59ef5c14fecd5e09eb90cef2dd28116485927016e02f3494fd2e7577ec","da3484ab08458ad0fb7c45efea5dddd25e0b6e09d355a743a78f707cc64c6328","e0fa60928c3c08ae672cdcbc075847a4a0b93bd2959271411a8e532419d13483","e76fd8c5e1db743a67cee69a93af3d33fa98e1f87a0ed656c0949f155d5b274f","f70a40a04a601096a7b18fb663e7ac3616d8373346a9bd8322f0f8eaae8cd793","fdc0a82ecd39940ffe3898950b7f51bb8f813201326d058b3ebc4b1955be41dc","fec2c976ca9011a2e966c029ba406163cfdd7e455a98253fa6524ad9f7043617"],"recordQualifiers":{},"scopeLabel":"OMIM:612469","sourceIds":["OMIM:612469"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."},{"gene":"","key":"MONDO:0008681/ORPHA:893","label":"WAGR syndrome","mondoId":"MONDO:0008681","onsetQualifier":null,"recordKeys":["1dd49854502e557c2752d7f0d70a8c9d07628d21657efa5f42793c6d8d53bd99","276086352fd853afd879624492c19e5494257d1f59257d50aed6d24b6f6aeb5d","2e12d9f9535df7d3fcbba658acc76cb778411ed71600cbb1f424cf294d6ab54f","46bfecdeee132a93c9685c0317cbfe5677a41861d7b64ba0e2e867a7a7acff7f","48ff9b6a8a980933620ef1a27d7ce4a196d01ad8c4fb410214c470a23ffbc4b5","539e277063ddd5d0b8cdf526d9f21c9d7f1ecea9ccd7b8e7df914daa14e3bddb","5787ed28795a22bc569629761cafc29788b9d933b7b4d2e274229094c9686b1d","6bae304ef179b1cfc92799b81b8628dc1af9efab604fc3e29ff487e97d3887a8","792ec002416a883f5fb64cd78f4a4d680e735834677d98402b69716cd2f87230","94260cd38d6ded3c67d5cd95ce8b6358335688e75d32841f3d8da7f2bf425182","986dfc88d0386455907da074b52285769a4435d1ea88e07eecb44f9fc9c6e348","aff3243a2f4ecf9490a740722fe11d10be14e0d6a1c40bce5cd83280ec360fe6","bbde416555ce44d40057e8aab987def58f6a6a4e478116be9d591a5180d8b5ed","d14a61b9f3bae0204fde5301b96089050c8ee2eec88e4f46a06cb54806ce5783","d5f7af9df72b15216500ce2262445c1131da47c30e061ee37a690307968e0e62","d8911fd9c26750d9fefefec6e7e6b2037c5c06b734b7c750760cda33c791fb3e","e6c8aecbc0dca7f7fda59440ec4b29cd82deee2ea89ebc97aa9035e1c984b75a","f3f7d76bed59601a553ebb97b89fb928c32418f2e120c4a3165d2ad18d87f4fe"],"recordQualifiers":{},"scopeLabel":"ORPHA:893","sourceIds":["ORPHA:893"],"sourceScope":"This column retains the native source entry. It is not a pooled estimate for the umbrella condition."}],"comparison":{"collapseColumnsLabel":"Show initial comparisons","defaultColumnKeys":["MONDO:0008681/OMIM:194072","MONDO:0012913/OMIM:612469","MONDO:0008681/ORPHA:893"],"expandColumnsLabel":"Compare all source entries","intro":"Compare the original source entries. Different entries may describe different patient groups.","primaryFeatureIds":[],"scopeNoteHtml":"

Each column keeps its native condition scope. Initial features are displayed alphabetically, not ranked by clinical importance. Counts remain separate, and an empty cell does not mean a feature cannot occur.

"},"coverage":{"countRecords":34,"emptyColumnKeys":[],"hpoRelease":"2026-06-23","narrativeSourceChanges":[],"records":62,"sourceGroups":{"omim":11,"orphanet":18,"published":33}},"features":[{"hpoId":"HP:0000142","label":"Abnormal vagina morphology","primary":false},{"hpoId":"HP:0000130","label":"Abnormality of the uterus","primary":false},{"hpoId":"HP:0000718","label":"Aggressive behavior","primary":false},{"hpoId":"HP:0000713","label":"Agitation","primary":false},{"hpoId":"HP:0000062","label":"Ambiguous genitalia","primary":false},{"hpoId":"HP:0000526","label":"Aniridia","primary":false},{"hpoId":"HP:0000739","label":"Anxiety","primary":false},{"hpoId":"HP:0008053","label":"Aplasia/Hypoplasia of the iris","primary":false},{"hpoId":"HP:0000729","label":"Autistic behavior","primary":false},{"hpoId":"HP:0000518","label":"Cataract","primary":false},{"hpoId":"HP:0000722","label":"Compulsive behaviors","primary":false},{"hpoId":"HP:0007957","label":"Corneal opacity","primary":false},{"hpoId":"HP:0000028","label":"Cryptorchidism","primary":false},{"hpoId":"HP:0008734","label":"Decreased testicular size","primary":false},{"hpoId":"HP:0000678","label":"Dental crowding","primary":false},{"hpoId":"HP:0100627","label":"Displacement of the urethral meatus","primary":false},{"hpoId":"HP:0000494","label":"Downslanted palpebral fissures","primary":false},{"hpoId":"HP:0007299","label":"Dysfunction of lateral corticospinal tracts","primary":false},{"hpoId":"HP:0010529","label":"Echolalia","primary":false},{"hpoId":"HP:0000712","label":"Emotional lability","primary":false},{"hpoId":"HP:0000232","label":"Everted lower lip vermilion","primary":false},{"hpoId":"HP:0000501","label":"Glaucoma","primary":false},{"hpoId":"HP:0000150","label":"Gonadoblastoma","primary":false},{"hpoId":"HP:0000364","label":"Hearing abnormality","primary":false},{"hpoId":"HP:0000666","label":"Horizontal nystagmus","primary":false},{"hpoId":"HP:0000822","label":"Hypertension","primary":false},{"hpoId":"HP:0012815","label":"Hypoplastic female external genitalia","primary":false},{"hpoId":"HP:0000047","label":"Hypospadias","primary":false},{"hpoId":"HP:0001249","label":"Intellectual disability","primary":false},{"hpoId":"HP:0000744","label":"Low frustration tolerance","primary":false},{"hpoId":"HP:0000369","label":"Low-set ears","primary":false},{"hpoId":"HP:0000272","label":"Malar flattening","primary":false},{"hpoId":"HP:0000303","label":"Mandibular prognathia","primary":false},{"hpoId":"HP:0000252","label":"Microcephaly","primary":false},{"hpoId":"HP:0000347","label":"Micrognathia","primary":false},{"hpoId":"HP:0002762","label":"Multiple exostoses","primary":false},{"hpoId":"HP:0000341","label":"Narrow forehead","primary":false},{"hpoId":"HP:0002667","label":"Nephroblastoma","primary":false},{"hpoId":"HP:0000112","label":"Nephropathy","primary":false},{"hpoId":"HP:0000639","label":"Nystagmus","primary":false},{"hpoId":"HP:0001513","label":"Obesity","primary":false},{"hpoId":"HP:0007906","label":"Ocular hypertension","primary":false},{"hpoId":"HP:0002591","label":"Polyphagia","primary":false},{"hpoId":"HP:0000093","label":"Proteinuria","primary":false},{"hpoId":"HP:0000508","label":"Ptosis","primary":false},{"hpoId":"HP:0012760","label":"Reduced social responsiveness","primary":false},{"hpoId":"HP:0000083","label":"Renal insufficiency","primary":false},{"hpoId":"HP:0002650","label":"Scoliosis","primary":false},{"hpoId":"HP:0004322","label":"Short stature","primary":false},{"hpoId":"HP:0010464","label":"Streak ovary","primary":false},{"hpoId":"HP:0000505","label":"Visual impairment","primary":false}],"ledeHtml":"WAGR syndrome is a disorder that affects many body systems and is named for its main features: Wilms tumor, aniridia, genitourinary anomalies, and a range of developmental delays.","mondoId":"MONDO:0008681","records":[{"frequencyKind":"count","key":"05b76d85d70499083b15722bfeb8b0b7633abaf88dfa70cf67f921d5db87a143","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"2/3","hpo_id":"HP:0000518","is_excluded":false,"label":"Cataract","onset_id":null,"reference":"PMID:11807873;PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"06800e9f4b2463431163ed1fec5fdd0e13de573ce40728aef22dfbda208b945c","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000678","is_excluded":false,"label":"Dental crowding","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"0b8003648fe6b527363e76831648ec7036790dde4514a781041f070bde08bb3c","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000713","is_excluded":false,"label":"Agitation","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"17190ad8f532fbd0594717996bde2e95f903b873a07bfd58c1eec91ba259c358","raw":{"aspect":"P","body_system":"growth","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"4/20","hpo_id":"HP:0001513","is_excluded":false,"label":"Obesity","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"1dd49854502e557c2752d7f0d70a8c9d07628d21657efa5f42793c6d8d53bd99","raw":{"aspect":"P","body_system":"eye","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000518","is_excluded":false,"label":"Cataract","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"24e935c592655701f475759daf5fbd2c90a9f52fd6340544f98d09df6c6d87e4","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000150","is_excluded":false,"label":"Gonadoblastoma","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"26eb2d9e43326ea1daad7c1060e147992168f5853c61872ecf6ac46dd6f0c096","raw":{"aspect":"P","body_system":"metabolic","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000093","is_excluded":false,"label":"Proteinuria","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"276086352fd853afd879624492c19e5494257d1f59257d50aed6d24b6f6aeb5d","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0007299","is_excluded":false,"label":"Dysfunction of lateral corticospinal tracts","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"2c38a28e4eb263c0fe839b57694c08e5d86265078814a61f774a801a5ff9c666","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000712","is_excluded":false,"label":"Emotional lability","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"2e12d9f9535df7d3fcbba658acc76cb778411ed71600cbb1f424cf294d6ab54f","raw":{"aspect":"P","body_system":"eye","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0008053","is_excluded":false,"label":"Aplasia/Hypoplasia of the iris","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"327875ccb0a9ccbd5da94a9ba3aa9632587a31baffab19e04908a8ce2031a8b5","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000718","is_excluded":false,"label":"Aggressive behavior","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"3db1387ebf8486ade7bdbf978211e9eac93b3986b425f65e90270987bb844058","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001249","is_excluded":false,"label":"Intellectual disability","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"3db3cc8e12082771b7446695ae0860ebbc8a488df856372b06fac0185dcb9753","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000272","is_excluded":false,"label":"Malar flattening","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"46bfecdeee132a93c9685c0317cbfe5677a41861d7b64ba0e2e867a7a7acff7f","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000028","is_excluded":false,"label":"Cryptorchidism","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"48ff9b6a8a980933620ef1a27d7ce4a196d01ad8c4fb410214c470a23ffbc4b5","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000232","is_excluded":false,"label":"Everted lower lip vermilion","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"51b43b6bab3a089bab8ec55c314c0ce357a6b407d45757f75c650c8cc3415950","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000047","is_excluded":false,"label":"Hypospadias","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"539e277063ddd5d0b8cdf526d9f21c9d7f1ecea9ccd7b8e7df914daa14e3bddb","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000347","is_excluded":false,"label":"Micrognathia","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"5787ed28795a22bc569629761cafc29788b9d933b7b4d2e274229094c9686b1d","raw":{"aspect":"P","body_system":"eye","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000501","is_excluded":false,"label":"Glaucoma","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"59613f67f037a2d81514f724cc8c926cb3a8402d6d7daa346686d2a00f2cced6","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"2/3","hpo_id":"HP:0002667","is_excluded":false,"label":"Nephroblastoma","onset_id":null,"reference":"PMID:11807873;PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"5efae714c92c4ca8673c3b90d3bb93f1212b8569adc2738d0c3db7e6af91952f","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000494","is_excluded":false,"label":"Downslanted palpebral fissures","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"67418e2ccf1980903adb33a09f9079820b17548e76f64e9de8856df07e4b5642","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000508","is_excluded":false,"label":"Ptosis","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"6a04ac5a4e209e008d72768b71a39c4cc527746c99e907201604800c5bf071b3","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"3/3","hpo_id":"HP:0001249","is_excluded":false,"label":"Intellectual disability","onset_id":null,"reference":"PMID:11807873;PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"6bae304ef179b1cfc92799b81b8628dc1af9efab604fc3e29ff487e97d3887a8","raw":{"aspect":"P","body_system":"eye","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000508","is_excluded":false,"label":"Ptosis","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"6ccb8cd34c548cd5dc5c52f8c823753e7f114a7647e1a7a99c405cc863d1dacc","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0000341","is_excluded":false,"label":"Narrow forehead","onset_id":null,"reference":"PMID:11807873","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"7116ab20401a302c3b2eaea54587ddcf51edb1cdb215380cf8555e5938941ab6","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0002591","is_excluded":false,"label":"Polyphagia","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"7317e94abd3859ae519a2ddc89ac9810c78f1979d5a5373ba5d4c51eff624779","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000028","is_excluded":false,"label":"Cryptorchidism","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"792ec002416a883f5fb64cd78f4a4d680e735834677d98402b69716cd2f87230","raw":{"aspect":"P","body_system":"eye","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000505","is_excluded":false,"label":"Visual impairment","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"reported","key":"79f396ac1b4db35cc5fe1260fa9fd126336d467ba621916d48f2c816ed2cd314","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":null,"hpo_id":"HP:0000112","is_excluded":false,"label":"Nephropathy","onset_id":"HP:0003581","reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"7b64e7c97e1122f9ac05ef6ceb9178511eebcb461f04261c0d8732a7d2e468d7","raw":{"aspect":"P","body_system":"cardiovascular","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000822","is_excluded":false,"label":"Hypertension","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"7f0934e1a5a77c27f719fda50ba72af28d919dd43cae2308d8e5b0f99e0d7f14","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0012815","is_excluded":false,"label":"Hypoplastic female external genitalia","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"84a5315250ad52271327366b198a60e4fe1a0411e449611ad1fa22298626dabe","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000739","is_excluded":false,"label":"Anxiety","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"8712a395136339c7705427dc9b60d244562b3d341f485fa18d1bfe8e80e58935","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0010464","is_excluded":false,"label":"Streak ovary","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"8a9ed7f4b0702c6396a26ce5c92604d4c61167671471953c9b6399b1b5aedf2c","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000142","is_excluded":false,"label":"Abnormal vagina morphology","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"range","key":"94260cd38d6ded3c67d5cd95ce8b6358335688e75d32841f3d8da7f2bf425182","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000252","is_excluded":false,"label":"Microcephaly","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"986dfc88d0386455907da074b52285769a4435d1ea88e07eecb44f9fc9c6e348","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0001249","is_excluded":false,"label":"Intellectual disability","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"9cab9786e9e06987787b49c1293a67a6c5f9978c08bf866d31514cff79b7fc75","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0012760","is_excluded":false,"label":"Reduced social responsiveness","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"9ebe1f51ecc2bd8a2d34a623772a899ec40117beee5110b564d229dd0fef86c7","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0002762","is_excluded":false,"label":"Multiple exostoses","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"a24fd9cc174e397ce93ee03a96d4ced57cb025f23f2107739cde02140e50f77b","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000666","is_excluded":false,"label":"Horizontal nystagmus","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"a3961e7446df80a62fa069c8bb736d9744f5a49ccf8f3c8473b07967bef49552","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000130","is_excluded":false,"label":"Abnormality of the uterus","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"a7c08b62cc7c90a3b44ff95a5a27d55849fc4a4e70bb4e7d07f8d1bcb8f4e627","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"PCS","frequency_raw":"10/46","hpo_id":"HP:0000083","is_excluded":false,"label":"Renal insufficiency","onset_id":"HP:0003581","reference":"PMID:10945603","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"abbca0f7af1079b0110b543cb2ff2f21de291df72b992164986a77e95d89f323","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0008734","is_excluded":false,"label":"Decreased testicular size","onset_id":null,"reference":"PMID:11807873","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"acac7ce7ac02db95c8ece3d60562879ad451e83cf0477846f5ea3c88492b17a9","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040281","hpo_id":"HP:0000526","is_excluded":false,"label":"Aniridia","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"ae67525e2a70f804875d31a1785b98355dec925aa6f04e562897f0c6ff4bae07","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/1","hpo_id":"HP:0000303","is_excluded":false,"label":"Mandibular prognathia","onset_id":null,"reference":"PMID:11807873","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"aff3243a2f4ecf9490a740722fe11d10be14e0d6a1c40bce5cd83280ec360fe6","raw":{"aspect":"P","body_system":"musculoskeletal","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0002650","is_excluded":false,"label":"Scoliosis","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"bb1d9d6ed084796c8f1b2ce06910dc4d6f62b2bb8952d993052d710fb26a51ed","raw":{"aspect":"P","body_system":"head_and_neck","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000347","is_excluded":false,"label":"Micrognathia","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"bbde416555ce44d40057e8aab987def58f6a6a4e478116be9d591a5180d8b5ed","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0100627","is_excluded":false,"label":"Displacement of the urethral meatus","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"bde2c7d9cf1f7038847833c706943c802d775539981b20242203679578119fc2","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"3/3","hpo_id":"HP:0000526","is_excluded":false,"label":"Aniridia","onset_id":null,"reference":"PMID:11807873;PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"c62668aa0737ca89da222357143f2489b7fee9eb6e242baebbcb05df23b4d094","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000729","is_excluded":false,"label":"Autistic behavior","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"d111d0a0a89f0864881c8ee66912330e5e63957e1062919ce4829191cd45c3da","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000744","is_excluded":false,"label":"Low frustration tolerance","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"d14a61b9f3bae0204fde5301b96089050c8ee2eec88e4f46a06cb54806ce5783","raw":{"aspect":"P","body_system":"growth","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0004322","is_excluded":false,"label":"Short stature","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"d4e5ff59ef5c14fecd5e09eb90cef2dd28116485927016e02f3494fd2e7577ec","raw":{"aspect":"P","body_system":"growth","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"2/2","hpo_id":"HP:0001513","is_excluded":false,"label":"Obesity","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"d5f7af9df72b15216500ce2262445c1131da47c30e061ee37a690307968e0e62","raw":{"aspect":"P","body_system":"genitourinary","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0000062","is_excluded":false,"label":"Ambiguous genitalia","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"range","key":"d8911fd9c26750d9fefefec6e7e6b2037c5c06b734b7c750760cda33c791fb3e","raw":{"aspect":"P","body_system":"growth","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040283","hpo_id":"HP:0001513","is_excluded":false,"label":"Obesity","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"da3484ab08458ad0fb7c45efea5dddd25e0b6e09d355a743a78f707cc64c6328","raw":{"aspect":"P","body_system":"ear","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000369","is_excluded":false,"label":"Low-set ears","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"dee318657ab4ba128bf0ffdd033e90b2b5bfd3084eb2b1d116400a03d388e51b","raw":{"aspect":"P","body_system":"neoplasm","disease_id":"OMIM:194072","disease_name":"Wilms tumor, aniridia, genitourinary anomalies and impaired intellectual development syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0002667","is_excluded":false,"label":"Nephroblastoma","onset_id":null,"reference":"OMIM:194072","source_release":"2026-06-23"},"sourceGroups":["omim"]},{"frequencyKind":"count","key":"e0fa60928c3c08ae672cdcbc075847a4a0b93bd2959271411a8e532419d13483","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0007957","is_excluded":false,"label":"Corneal opacity","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"e6c8aecbc0dca7f7fda59440ec4b29cd82deee2ea89ebc97aa9035e1c984b75a","raw":{"aspect":"P","body_system":"ear","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000364","is_excluded":false,"label":"Hearing abnormality","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"e76fd8c5e1db743a67cee69a93af3d33fa98e1f87a0ed656c0949f155d5b274f","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"2/2","hpo_id":"HP:0000505","is_excluded":false,"label":"Visual impairment","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"range","key":"f3f7d76bed59601a553ebb97b89fb928c32418f2e120c4a3165d2ad18d87f4fe","raw":{"aspect":"P","body_system":"eye","disease_id":"ORPHA:893","disease_name":"WAGR syndrome","evidence":"TAS","frequency_raw":"HP:0040282","hpo_id":"HP:0000639","is_excluded":false,"label":"Nystagmus","onset_id":null,"reference":"ORPHA:893","source_release":"2026-06-23"},"sourceGroups":["orphanet"]},{"frequencyKind":"count","key":"f70a40a04a601096a7b18fb663e7ac3616d8373346a9bd8322f0f8eaae8cd793","raw":{"aspect":"P","body_system":"eye","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0007906","is_excluded":false,"label":"Ocular hypertension","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"fdc0a82ecd39940ffe3898950b7f51bb8f813201326d058b3ebc4b1955be41dc","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0010529","is_excluded":false,"label":"Echolalia","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]},{"frequencyKind":"count","key":"fec2c976ca9011a2e966c029ba406163cfdd7e455a98253fa6524ad9f7043617","raw":{"aspect":"P","body_system":"nervous_system","disease_id":"OMIM:612469","disease_name":"WAGRO syndrome","evidence":"PCS","frequency_raw":"1/2","hpo_id":"HP:0000722","is_excluded":false,"label":"Compulsive behaviors","onset_id":null,"reference":"PMID:15702131","source_release":"2026-06-23"},"sourceGroups":["published"]}],"referenceLabels":{},"references":{"causeHtml":"","identityNote":"MONDO cross-references identify native condition entries. Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"

WAGR syndrome is caused by a deletion of genetic material on the short (p) arm of chromosome 11. The size of the deletion varies among affected individuals.

The signs and symptoms of WAGR syndrome are related to the loss of multiple genes on the short arm of chromosome 11. WAGR syndrome is often described as a contiguous gene deletion syndrome because it is caused by the loss of several neighboring genes.

The PAX6 and WT1 genes are always deleted in people with the typical signs and symptoms of this disorder. Because changes in the PAX6 gene can affect eye development, researchers think that the loss of the PAX6 gene causes the characteristic eye features of WAGR syndrome. The PAX6 gene may also affect brain development.

Variants (also called mutations) in the WT1 gene can cause Wilms tumor and genitourinary abnormalities, so deletion of the WT1 gene is very likely the cause of these features in people with WAGR syndrome.

In people with WAGRO syndrome, an additional gene is deleted from chromosome 11. The BDNF gene is active (expressed) in the brain and plays a role in the survival of nerve cells (neurons). The protein produced from the BDNF gene is thought to be involved in the management of eating, drinking, and body weight. Loss of the BDNF gene is likely the cause of childhood-onset obesity in people with WAGRO syndrome.

People with WAGRO syndrome may be at greater risk of neurological problems such as intellectual disability and autism than those with WAGR syndrome. It is unclear whether this increased risk is due to the loss of the BDNF gene or other nearby genes.

Researchers are still studying the genes that are deleted in people with WAGR syndrome and determining how the loss of these genes causes features of the disorder.

MedlinePlus Genetics: Causes

","key":"forms","title":"What causes WAGR syndrome?"},{"bodyHtml":"

People with WAGR syndrome have a 45 to 60 percent chance of developing Wilms tumor, a rare form of kidney cancer. This type of cancer is most often diagnosed in children but is sometimes seen in adults. Some people with WAGR syndrome develop nephrogenic rests, which are abnormal clumps of cells in the kidneys. These can lead to Wilms tumor, but some people with nephrogenic rests never develop Wilms tumor.

Most people with WAGR syndrome have aniridia, an absence of the colored part of the eye (the iris). This can reduce the sharpness of a person's vision (visual acuity) and increase sensitivity to light (photophobia). Aniridia is typically the first noticeable sign of WAGR syndrome. Other eye problems may also develop, such as clouding of the lens of the eyes (cataracts), increased pressure in the eyes (glaucoma), and involuntary eye movements (nystagmus).

Abnormalities of the genitalia and urinary tract (genitourinary anomalies) are seen more frequently in males with WAGR syndrome than in affected females. The most common genitourinary abnormality in affected males is undescended testes (cryptorchidism). Affected females may not have functional ovaries and may instead have undeveloped clumps of tissue called streak gonads. Females with WAGR syndrome may also have a heart-shaped (bicornate) uterus, which makes it difficult to carry a pregnancy to term.

Intellectual disability and other developmental delays are also common in people with WAGR syndrome. Affected individuals often have difficulty processing, learning, and properly responding to information. Many affected individuals have difficulty speaking or understanding language. Some individuals with WAGR syndrome also have psychiatric or behavioral problems such as depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or a developmental disorder called autism spectrum disorder that affects communication and social interaction.

Other signs and symptoms of WAGR syndrome can include ongoing constipation, inflammation of the pancreas (pancreatitis), kidney failure, breathing problems, and allergies. Some affected children have obesity. When WAGR syndrome includes childhood-onset obesity, it is often referred to as WAGRO syndrome.

Source: MedlinePlus Genetics

","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"wagr-syndrome","sourceDocuments":[{"name":"WAGR syndrome","reviewed":"2023-06","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:45.202739+00:00","label":"Causes","pageSha256":"61a3a6017b6f298c745523d8e9c138fe08c4f47a684a22318dfd20ed4ccf08f6","sourceUrl":"https://medlineplus.gov/genetics/condition/wagr-syndrome/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/wagr-syndrome"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"WAGR syndrome"},"schemaVersion":1}