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Ancestor membership does not transfer phenotype values between groups.","importantHtml":""},"sections":[{"bodyHtml":"<p>Variants (also known as mutations) in the IL2RG gene cause X-linked SCID. The IL2RG gene provides instructions for making a protein that is critical for normal immune system function. This protein is necessary for the growth and maturation of developing immune system cells called lymphocytes. Lymphocytes defend the body against potentially harmful invaders, make antibodies, and help regulate the entire immune system. Variants in the IL2RG gene prevent these cells from developing and functioning normally. Without functional lymphocytes, the body is unable to fight off infections.</p><p class=\"section-source\"><a href=\"https://medlineplus.gov/genetics/condition/x-linked-severe-combined-immunodeficiency/#causes\">MedlinePlus Genetics: Causes</a></p>","key":"forms","title":"What causes X-linked severe combined immunodeficiency?"},{"bodyHtml":"<p>If untreated, infants with X-linked SCID can develop poor growth, chronic diarrhea, a fungal infection called thrush, skin rashes, and life-threatening infections. X-linked SCID can be detected shortly after birth by newborn screening, which allows for prompt treatment.</p><p class=\"section-source\">Source: <a href=\"https://medlineplus.gov/genetics/condition/x-linked-severe-combined-immunodeficiency\">MedlinePlus Genetics</a></p>","key":"overview","title":"Condition overview"}],"sharedSources":[],"slug":"x-linked-severe-combined-immunodeficiency","sourceDocuments":[{"name":"X-linked severe combined immunodeficiency","reviewed":"2022-03","sections":{"causes":{"fetchedAt":"2026-10-20T20:25:59.943879+00:00","label":"Causes","pageSha256":"89e8807ea4139849235d19ff80450e795352284f4ff0dca65e7864b9e1955ead","sourceUrl":"https://medlineplus.gov/genetics/condition/x-linked-severe-combined-immunodeficiency/#causes","status":"available"}},"source_release":"2026-10-01","url":"https://medlineplus.gov/genetics/condition/x-linked-severe-combined-immunodeficiency"}],"sourceNote":"MedlinePlus descriptions and Causes; original HPO annotations.","takeawayHtml":"Cause explanations are from MedlinePlus Genetics. Feature values below retain their original sources and patient groups.","title":"X-linked severe combined immunodeficiency"},"schemaVersion":1}